RGS2 Background Information Heterotrimeric G proteins function to relay information from cell surface receptors to intracellular effectors (1). In mammals, G protein a, b and g polypeptides are encoded by at least 16, 4 and 7 genes, respectively (2–6). Most interest in G proteins has been focused on their a subunits, since these proteins bind and hydrolyze GTP and most obviously regulate the activity of the best studied effectors. Several Ga GTP-ase activating proteins (GAPs) have been identified and are designated RGS1, RGS2, RGS4, RGS7, RGS9, RGS10 and GAIP (Gå-interacting protein). Each of these proteins has been shown to deactivate specific Gå isoforms by increasing the rate at which they convert GTP to GDP (7). RGS2 has been shown to be an inhibitor of Gåq function (8). RGS9 expression is restricted to photoreceptor cells and RGS9 has been shown to regulate Gåt (9).
RGS2 (BC-43)
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RGS2 (BC-43): sc-100761. Western blot analysis of RGS2 expression in MCF7 whole cell lysate.
RGS2 (BC-43): sc-100761. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human tonsil tissue showing cytoplasmic localization.
RGS2 (BC-43): sc-100761. Western blot analysis of RGS2 expression in non-transfected: sc-117752 (A) and mouse RGS2 transfected: sc-123104 (B) 293T whole cell lysates and mouse brain tissue extract (C).
