santa cruz biotechnology, inc.
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- mouse monoclonal IgG1, 50 µg/0.5 ml
- raised against recombinant eIF2Bb of human origin
- recommended for detection of eIF2Bβ of human origin by WB, IP, IF, IHC(P) and ELISA
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Ordering Information
Recommended Support Products:
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
EIF2B2 |
8892 |
14q24.3 |
NM_014239 |
P49770
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606454 |
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eIF2Bβ Background Information
The initiation of protein synthesis in eukaryotic cells is regulated by interactions between protein initiation factors and RNA molecules. The eukaryotic initiation complex eIF2B exists as a five subunit complex composed of eIF2Bå, eIF2Bß, eIF2B©, eIF2B∂, and eIF2Bé. The eIF2B complex catalyzes the exchange of GDP for GTP on the eIF2 complex, following the interaction of eIF2/GTP with the 40S ribosomal subunit. Guanine nucleotide exchange factor (GEF) activity is exhibited by the eIF2Bé subunit alone, but is greater in the presence of all five eIF2B subunits. Phosphorylation of eIF2 inhibits GEF activity of eIF2B, an inhibition that requires the eIF2Bå subunit. |
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eIF2Bβ (YY7)
Click on image to enlarge
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eIF2Bb (YY7): sc-100729. Western blot analysis of eIF2Bb expression in K-562 whole cell lysate.
eIF2Bb (YY7): sc-100729. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human lymphoma tissue showing cytoplasmic localization.
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