UBE2G2 Background Information UBE2G2 (Ubiquitin-conjugating enzyme E2 G2), also known as UBC7, is a 165 amino acid protein involved in ubiquitin-mediated protein degradation. Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). UBE2G2 is an E2 ubiquitin-conjugating enzyme that acts to catalyze the covalent attachment of ubiquitins to various proteins. Expressed throughout the body, UBE2G2 shares 100% sequence identity with its mouse counterpart and is thought to be involved in endoplasmic reticulum-associated degradation (ERAD). Two isoforms of UBE2G2 exist due to alternative splicing events.
UBE2G2 (2E6)
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UBE2G2 (2E6): sc-100613. Western blot analysis of UBE2G2 expression in HeLa whole cell lysate.
UBE2G2 (2E6): sc-100613. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human liver tissue showing cytoplasmic localization.
UBE2G2 (2E6): sc-100613. Western blot analysis of UBE2G2 expression in non-transfected: sc-117752 (A) and mouse UBE2G2 transfected: sc-124414 (B) 293T whole cell lysates.
