ACD Background Information ACD (adrenocortical dysplasia homolog), also known as PIP1, PTOP, TPP1 or TINT1 is a 544 amino acid human homolog of the mouse Acd protein and is one of six components in the telosome/shelterin complex; a complex involved in shaping and guarding telomeres. ACD is essential for the proper assembly and stabilization of the telomere-associated complex and is able to interact directly with POT1 (protection of telomeres 1) and TRF1 (telomeric repeat binding factor 1), two additional members of the multi-protein complex. Localized to the nucleus, ACD helps to control telomere length and elongation by mediating telomerase activity and telomerase access to DNA. Through its ability to control and maintain telomere growth, ACD is thought to be involved in organogenesis. Two isoforms of ACD are expressed due to alternative splicing events.
ACD (AA-2)
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ACD (AA-2): sc-100597. Western blot analysis of ACD expression in IMR-32 whole cell lysate.
ACD (AA-2): sc-100597. Immunofluorescence staining of paraformaldehyde-fixed HeLa cells showing nuclear localization.
ACD (AA-2): sc-100597. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human heart tissue showing nuclear localization.
ACD (AA-2): sc-100597. Western blot analysis of ACD expression in non-transfected 293T: sc-117752 (A), human ACD transfected 293T: sc-113400 (B) and IMR-32 (C) whole cell lysates.
