CBS Background Information Strongly expressed in human liver and pancreas, with weaker expression in heart and brain, the cytoplasmic protein cystathionine b-synthase (CBS) operates in the first step of homocysteine transulfuration. CBS, which belongs to the cysteine synthase/cystathionine b-synthase family of proteins, catalyzes the formation of cystathionine from the thrombogenic amino acid homocysteine using pyridoxal phosphate cofactor. Allosteric activation by adenosyl-methionine regulates CBS activity. Deficiencies in CBS are assoc-iated with homocystinuria, a recessively inherited error in sulfur amino acid metabolism that affects many organs and tissues. Symptoms of homocytinuria include arteriosclerosis, thrombosis, dislocated optic lenses, mental retard-ation and skeletal abnormalities.
CBS (15X)
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CBS (15X): sc-100519. Western blot analysis of CBS expression in non-transfected: sc-117752 (A) and mouse CBS transfected: sc-119049 (B) 293T whole cell lysates and mouse pancreas tissue extract (C).
CBS (15X): sc-100519. Western blot analysis of CBS expression in non-transfected 293: sc-110760 (A), MIA PaCa-2 (B) and human CBS transfected 293: sc-111129 (C) whole cell lysates.
CBS (15X): sc-100519 Western blot analysis of CBS expression in human CBS transfected (A) and non-transfected (B) 293T whole cell lysates.
CBS (15X): sc-100519. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human hepatocellular carcinoma tissue showing cytoplasmic localization.
CBS (15X): sc-100519. Western blot analysis of CBS expression in non-transfected: sc-117752 (A) and human CBS transfected: sc-170537 (B) 293T whole cell lysates.
