AKR1B10 Background Information AKR1B10 (aldo-keto reductase family 1 member B10) is also known as aldose reductase-like-1 (ARL-1), small intestine reductase (SI reductase) or aldose reductase-related protein (ARP or hARP). AKR1B10 is found in many tissues but is predominantly expressed in small intestine, colon and adrenal gland. AKR1B10 is an efficient reductase for aliphatic and aromatic aldehydes. It plays a role in steroid metabolism as well as detoxification of aldehydes in digested food, and may be involved in the retinal-retinoic acid signaling pathway. AKR1B10 is prominently overexpressed in non-small cell lung carcinoma and adenocarcinoma. Cigarette smoking is an independent variable responsible for this overexpression. AKR1B10 may play a role regulating cell proliferation and cellular response to carbonyl stress.
AKR1B10 (AA-1)
Click on image to enlarge
AKR1B10 (AA-1): sc-100501. Western blot analysis of AKR1B10 expression in Hep G2 whole cell lysate.
AKR1B10 (AA-1): sc-100501. Immunofluorescence staining of paraformaldehyde-fixed HeLa cells showing cytoplasmic localization.
AKR1B10 (AA-1): sc-100501. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human colon tissue showing cytoplasmic localization.
AKR1B10 (AA-1): sc-100501. Western blot analysis of AKR1B10 expression in non-transfected: sc-117752 (A) and human AKR1B10 transfected: sc-175413 (B) 293T whole cell lysates.
