Ketohexokinase (TT-I) Antibody: sc-100381

Ketohexokinase Background Information
The hexokinases utilize Mg-ATP as a phosphoryl donor to catalyze the first step of intracellular glucose metabolism, the conversion of glucose to glucose-6-phosphate. Ketohexokinase (hepatic fructokinase) belongs to the carbohydrate kinase pfkB family and requires potassium. It functions in the metabolism of dietary fructose in mammals, catalyzing the conversion of fructose to fructose-1-phosphate. Ketohexokinase is expressed most abundantly in kidney, liver, pancreas and spleen, while lower levels are seen in muscle, eye and brain. Mutations in KHK, the gene encoding for Ketohexokinase, cause fructosuria, a benign defect of intermediary metabolism characterized by the excretion of fructose in the urine.