CaMKKβ Antibody (ZZ9): sc-100364
- CaMKKβ Antibody (ZZ9) is a mouse monoclonal IgG1 κ, cited in 15 publications, provided at 100 µg/ml
- raised against recombinant CaMKKβ of human origin
- recommended for detection of CaMKKβ of human and rat origin by WB, IP and ELISA
- See CaMKKβ (C-11): sc-271674 for CaMKKβ antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CaMKKβ Antibody (ZZ9). This work is in progress.
CaMKKβ Antibody (ZZ9) is a mouse monoclonal IgG1 antibody that detects CaMKKβ in human and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). CaMKKβ plays a crucial role in cellular signaling by acting as a key regulator of the Ca2+/calmodulin-dependent protein kinase pathway, which is essential for various physiological processes, including muscle contraction, neurotransmitter release, and gene expression. CaMKKβ is primarily located in the cytoplasm and is activated in response to increases in intracellular calcium levels, highlighting CaMKKβ′s importance in translating calcium signals into cellular responses. CaMKKβ activation leads to the phosphorylation of downstream targets, such as CaMKI and CaMKIV, which further propagate the signaling cascade. Understanding CaMKKβ function and regulation is vital, as dysregulation of this pathway has been implicated in various diseases, including cancer and neurodegenerative disorders. Anti-CaMKKβ antibody (ZZ9) is an invaluable tool for researchers aiming to explore the intricate mechanisms of calcium signaling and its implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CaMKKβ Antibody (ZZ9) References:
- TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKβ/VPS34 pathway. | Scotto Rosato, A., et al. 2019. Nat Commun. 10: 5630. PMID: 31822666
- Orexin A alleviates neuroinflammation via OXR2/CaMKKβ/AMPK signaling pathway after ICH in mice. | Li, T., et al. 2020. J Neuroinflammation. 17: 187. PMID: 32539736
- Traumatic-noise-induced hair cell death and hearing loss is mediated by activation of CaMKKβ. | Wu, F., et al. 2022. Cell Mol Life Sci. 79: 249. PMID: 35438341
- TRPM7-Mediated Ca2+ Regulates Mussel Settlement through the CaMKKβ-AMPK-SGF1 Pathway. | He, J., et al. 2023. Int J Mol Sci. 24: PMID: 36982474
- OR2H2 Activates CAMKKβ-AMPK-Autophagy Signaling Axis and Suppresses Senescence in VK2/E6E7 Cells. | Kim, JM., et al. 2023. Pharmaceuticals (Basel). 16: PMID: 37765029
- Omega-3 polyunsaturated fatty acids protect peritoneal mesothelial cells from hyperglycolysis and mesothelial-mesenchymal transition through the FFAR4/CaMKKβ/AMPK/mTOR signaling pathway. | Zhang, J., et al. 2024. Int Immunopharmacol. 128: 111561. PMID: 38262160
- FGF4 protects the liver from immune-mediated injury by activating CaMKKβ-PINK1 signal pathway to inhibit hepatocellular apoptosis. | Huang, Z., et al. 2024. Acta Pharm Sin B. 14: 1605-1623. PMID: 38572102
- Aberrant expression of NEDD4L disrupts mitochondrial homeostasis by downregulating CaMKKβ in diabetic kidney disease. | Han, F., et al. 2024. J Transl Med. 22: 465. PMID: 38755664
- Inhibition of endoplasmic reticulum stress and excessive autophagy by Jiedu Tongluo Tiaogan Formula via a CaMKKβ/AMPK pathway contributes to protect pancreatic β-cells. | Zhang, Q., et al. 2024. J Ethnopharmacol. 333: 118440. PMID: 38885916
- Liraglutide alleviates high-fat diet-induced kidney injury in mice by regulating the CaMKKβ/AMPK pathway. | Xuan, Y., et al. 2024. Ren Fail. 46: 2351473. PMID: 38915241
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CaMKKβ Antibody (ZZ9) | sc-100364 | 100 µg/ml | $339.00 |