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NEEP21 Antibody (364.1): sc-100329

 |  Datasheet

(Based on data analysis)
  • NEEP21 Antibody (364.1) is a mouse monoclonal IgG1 provided at 100 µg/ml
  • raised against recombinant NEEP21 of human origin
  • recommended for detection of NEEP21 of human origin by WB, IP and ELISA
 

See additional NEEP Antibodies.

Ordering InformationGene Info
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
NEEP21 Antibody (364.1) sc-100329 100 µg/ml $295
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
NEEP21 siRNA (h) sc-62671 10 µM $258
NEEP21 (h)-PR sc-62671-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
NEEP21 shRNA Plasmid (h) sc-62671-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
NEEP21 shRNA (h) Lentiviral Particles sc-62671-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
IMR-32 Cell Lysate sc-2409 500 µg/200 µl $104
NEEP21 (m): 293T Lysate sc-121993 100 µg/200 µl $205
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human D4S234E 27065 4p16.2 NM_001040101, NM_014392 P42857
 607645
 

NEEP21 (neuron-enriched endosomal 21kDa protein), also known as Brain neuron cytoplasmic protein 1, NSG1 (neuron-specific proteins family member 1), P21 or D4S234E, is a single pass type II membrane protein belonging to the NSG family. It is highly expressed during neuronal maturation but its expression is downregulated in adult tissues. NEEP21 predominantly localizes to Rab 4-positive early endosomes in the somatodendritic neuronal compartment and is essential for proper receptor sorting and recycling in neurons. It associates with GRIP1 and GluR-2 and mediates the surface expression of GluR-2. When this interaction is interrupted, GluR-2 accumulates in early endosomes and leads to changes in evoked synaptic current properties. In addition, NEEP21 forms a complex with the SNARE protein, Syntaxin 13 (also known as Syntaxin 12), and participates in the recycling of transferrin receptors (TFRs) and NTR2 (neurotensin receptor 2).