Aladin Background Information Aladin (Adracalin) belongs to a family of WD repeat-containing proteins. These proteins have a wide variety of functions, including signal transduction regulation, RNA processing and transcription. Aladin plays a role in peripheral and central nervous system development. It is widely expressed, with the highest expression seen in pituitary gland, corpus callosum, cerebellum, adrenal gland and gastrointestinal structures. Defects in Aladin cause the autosomal recessive disorder achalasia-addisonianism-alacrima (triple A) syndrome. Triple A syndrome is characterized by achalasia, alacrima and adrenocortico-tropin-resistant adrenal insufficiency. Robust expression in neural systems associated with cognitive, motor and sensory functions is consistent with the myriad of symptoms experienced by patients with triple A syndrome.
Aladin (3E9)
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Aladin (3E9): sc-100321. Western blot analysis of Aladin expression in HeLa whole cell lysate.
Aladin (3E9): sc-100321. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human prostate tissue showing cytoplasmic localization.
Aladin (3E9): sc-100321. Western blot analysis of Aladin expression in non-transfected: sc-117752 (A) and mouse Aladin transfected: sc-118321 (B) 293T whole cell lysates.
Aladin (3E9): sc-100321. Western blot analysis of Aladin expression in non-transfected: sc-117752 (A) and mouse Aladin transfected: sc-118322 (B) 293T whole cell lysates.
