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GC-C Antibody (537): sc-100302

 |  Datasheet

(Based on data analysis)

  • GC-C Antibody (537) is a mouse monoclonal IgG2b provided at 100 µg/ml
  • raised against recombinant GC-C of human origin
  • recommended for detection of GC-C of human origin by WB, IP and ELISA

See additional Guanylate Cyclases Antibodies.

Also see chemical Guanylate Cyclases Inhibitors or chemical Guanylate Cyclases Activators for functional analysis of cellular responses to Guanylate Cyclases.

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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
GC-C Antibody (537) sc-100302 100 µg/ml $295
 CRISPR/Cas9 KO and HDR Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GC-C CRISPR/Cas9 KO Plasmid (h) sc-403413 20 µg $345
GC-C HDR Plasmid (h) sc-403413-HDR 20 µg $385
GC-C CRISPR/Cas9 KO Plasmid (m) sc-420736 20 µg $345
GC-C HDR Plasmid (m) sc-420736-HDR 20 µg $385
Gucy2d CRISPR/Cas9 KO Plasmid (m) sc-420737 20 µg $345
Gucy2d HDR Plasmid (m) sc-420737-HDR 20 µg $385
Gucy2g CRISPR/Cas9 KO Plasmid (m) sc-428623 20 µg $345
Gucy2g HDR Plasmid (m) sc-428623-HDR 20 µg $385
 CRISPR Activation Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GC-C CRISPR Activation Plasmid (h) sc-403413-ACT 20 µg $345
GC-C CRISPR Activation Plasmid (m) sc-420736-ACT 20 µg $345
Gucy2d CRISPR Activation Plasmid (m) sc-420737-ACT 20 µg $345
Gucy2g CRISPR Activation Plasmid (m) sc-428623-ACT 20 µg $345
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GC-C siRNA (h) sc-45492 10 µM $258
GC-C (h)-PR sc-45492-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GC-C shRNA Plasmid (h) sc-45492-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GC-C shRNA (h) Lentiviral Particles sc-45492-V 200 µl $625
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human GUCY2C 2984 12p13.1 NM_004963 P25092

Guanylate Cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase, a soluble form (GCS or sGC), which act as receptors for nitric oxide, and a membrane-bound receptor form (GC), which are peptide hormone receptors. The GC-C protein is composed of an extracellular domain, a single transmembrane domain, and a cytoplasmic region consisting of a kinase-like domain and a catalytic domain. It is expressed as two differentially glycosylated forms, a precursor form present in the endoplasmic reticulum and a form present on the plasma membrane. Ligand binding to the extracellular domain of GC-C promotes the accumulation of cGMP. GC-C acts as the receptor for heat-stable enterotoxins, small peptides secreted by some pathogenic strains of E. coli that cause severe secretory diarrhea. GC-C also binds to guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load.

GC-C Antibody (537) Data
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GC-C (537): sc-100302. Western blot analysis of GC-C expression in 293 whole cell lysate.