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GC-C Antibody (537): sc-100302

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  • GC-C Antibody (537) is a mouse monoclonal IgG2b provided at 100 µg/ml
  • raised against recombinant GC-C of human origin
  • recommended for detection of GC-C of human origin by WB, IP and ELISA
 

See additional Guanylate Cyclases Antibodies.

Also see chemical Guanylate Cyclases Inhibitors or chemical Guanylate Cyclases Activators for functional analysis of cellular responses to Guanylate Cyclases.


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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
GC-C Antibody (537) sc-100302 100 µg/ml $295
 CRISPR KO, HDR and Nickase Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GC-C CRISPR/Cas9 KO Plasmid (h) sc-403413 20 µg $345
GC-C HDR Plasmid (h) sc-403413-HDR 20 µg $385
GC-C Double Nickase Plasmid (h) sc-403413-NIC 20 µg $355
GC-C Double Nickase Plasmid (h2) sc-403413-NIC-2 20 µg $355
GC-C CRISPR/Cas9 KO Plasmid (m) sc-420736 20 µg $345
GC-C HDR Plasmid (m) sc-420736-HDR 20 µg $385
GC-C Double Nickase Plasmid (m) sc-420736-NIC 20 µg $355
GC-C Double Nickase Plasmid (m2) sc-420736-NIC-2 20 µg $355
Gucy2d CRISPR/Cas9 KO Plasmid (m) sc-420737 20 µg $345
Gucy2d HDR Plasmid (m) sc-420737-HDR 20 µg $385
Gucy2d Double Nickase Plasmid (m) sc-420737-NIC 20 µg $355
Gucy2d Double Nickase Plasmid (m2) sc-420737-NIC-2 20 µg $355
Gucy2g CRISPR/Cas9 KO Plasmid (m) sc-428623 20 µg $345
Gucy2g HDR Plasmid (m) sc-428623-HDR 20 µg $385
Gucy2g Double Nickase Plasmid (m) sc-428623-NIC 20 µg $355
Gucy2g Double Nickase Plasmid (m2) sc-428623-NIC-2 20 µg $355
 CRISPR Activation Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GC-C CRISPR Activation Plasmid (h) sc-403413-ACT 20 µg $345
GC-C CRISPR Activation Plasmid (h2) sc-403413-ACT-2 20 µg $345
GC-C Lentiviral Activation Particles (h) sc-403413-LAC 200 µl $395
GC-C Lentiviral Activation Particles (h2) sc-403413-LAC-2 200 µl $395
GC-C CRISPR Activation Plasmid (m) sc-420736-ACT 20 µg $345
GC-C CRISPR Activation Plasmid (m2) sc-420736-ACT-2 20 µg $345
GC-C Lentiviral Activation Particles (m) sc-420736-LAC 200 µl $395
GC-C Lentiviral Activation Particles (m2) sc-420736-LAC-2 200 µl $395
Gucy2d CRISPR Activation Plasmid (m) sc-420737-ACT 20 µg $345
Gucy2d CRISPR Activation Plasmid (m2) sc-420737-ACT-2 20 µg $345
Gucy2d Lentiviral Activation Particles (m) sc-420737-LAC 200 µl $395
Gucy2d Lentiviral Activation Particles (m2) sc-420737-LAC-2 200 µl $395
Gucy2g CRISPR Activation Plasmid (m) sc-428623-ACT 20 µg $345
Gucy2g CRISPR Activation Plasmid (m2) sc-428623-ACT-2 20 µg $345
Gucy2g Lentiviral Activation Particles (m) sc-428623-LAC 200 µl $395
Gucy2g Lentiviral Activation Particles (m2) sc-428623-LAC-2 200 µl $395
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GC-C siRNA (h) sc-45492 10 µM $258
GC-C (h)-PR sc-45492-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GC-C shRNA Plasmid (h) sc-45492-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GC-C shRNA (h) Lentiviral Particles sc-45492-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human GUCY2C 2984 12p13.1 NM_004963 P25092
601330
 


Guanylate Cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase, a soluble form (GCS or sGC), which act as receptors for nitric oxide, and a membrane-bound receptor form (GC), which are peptide hormone receptors. The GC-C protein is composed of an extracellular domain, a single transmembrane domain, and a cytoplasmic region consisting of a kinase-like domain and a catalytic domain. It is expressed as two differentially glycosylated forms, a precursor form present in the endoplasmic reticulum and a form present on the plasma membrane. Ligand binding to the extracellular domain of GC-C promotes the accumulation of cGMP. GC-C acts as the receptor for heat-stable enterotoxins, small peptides secreted by some pathogenic strains of E. coli that cause severe secretory diarrhea. GC-C also binds to guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load.

GC-C Antibody (537) Product Reviews

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GC-C Antibody (537) Data
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GC-C (537): sc-100302. Western blot analysis of GC-C expression in 293 whole cell lysate.
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