TAPBPL Background Information TAPBPL (TAP binding protein-like), also known as TAPBPR or TAPBP-R, is a 468 amino acid protein that contains one Ig-like (immunoglobulin-like) C1-type domain and one Ig-like V-type domain. Localized to the membrane of both the endoplasmic reticulum (ER) and the microsome, TAPBPL is a single-pass type I membrane protein that is similar to TPN (also known as TAPBP or Tapasin), a transmembrane glycoprotein that belongs to the variable-constant Ig superfamily. TPN functions to link the ER-associated antigen transporter TAP with major histocompatibility complex (MHC) class I molecules, thereby mediating peptide loading onto MHC proteins. Due to its similarity with TPN, TAPBPL is thought to play a role in antigen processing events within the ER.
TAPBPL (42-L)
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TAPBPL (42-L): sc-100290. Western blot analysis of TAPBPL expression in A-431 whole cell lysate.
