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PRODUCT NAMECATALOG #DESCRIPTIONCITATIONSRANKING
1-Oleoyl-2-acetyl-sn-glycerol (OAG)sc-200417A membrane-permeable, synthetic diacylglycerol analog, activator of Ca2+-dependent protein kinase C. CAS # 86390-77-4

2-APBsc-2014872-APB is a TRP inhibitor that also directly blocks the mitochondrial permeability transition pore, sarco/endoplasmic reticulum Ca2-ATPase pumps, and native store operated channels. CAS # 524-95-8

1
3-Indoleacrylic acidsc-256519Induces transcription of genes under the control of the trpE promoter. IAA also transcriptionally activates gene expression in plants. Some of the genes that are induced by IAA encode a family of proteins that contain nuclear localization signals that direct a β-glucuronidase reported protein into the nucleus. CAS # 1204-06-4

6-Iodonordihydrocapsaicinsc-203785A potent transient receptor potential vanilloid-1 (TRPV1) channel antagonist. Used in place of Capsazepine to investigate vanilloid receptor agonists. CAS # 859171-97-4

6'-Iodononivamidesc-221109Strong competitive TRPV1 antagonist. Convenient replacement for capsazepine in most of the in vitro preparations currently used to assess the activity of putative vanilloid receptor agonists.

6’-Iodoresiniferatoxinsc-2020256'-Iodoresiniferatoxin is a high affinity TRPV1 (VR1) vanilloid receptor partial agonist.

AMG-9810sc-201477A vanilloid receptor 1 antagonist which blocks a variety of known modes of VR1 activation. Also has been shown to block capsaicin-evoked depolarization and calcitonin gene-related peptide release. CAS # 545395-94-6

AP-18sc-203822AP-18 is a novel TRPA1 channel blocker (CHO cells, IC50= 3.1 μM; human and mouse cell lines, IC50= 4.5 μM). It reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation demonstrating selectivity vs. TRPV11. CAS # 55224-94-7

Arachidonic Acid (20:4, n-6)sc-200770A precursor to numerous eicosanoids as well as other bioactive molecules that can cause activation of protein kinase C. CAS # 506-32-1

BCTCsc-205599An effective and potent transient receptor potential vanilloid-1 (TRPV1) channel antagonist. CAS # 393514-24-4

2
Capsaicinsc-3577Capsaicin is an agonist at the TRPV1 capsaicin receptor, a ligand-gated non-selective cation channel. Exhibits neuroprotective effects in a model of transient global cerebral ischemia; reversibly inhibits platelet aggregation. CAS # 404-86-4

10
Eugenolsc-203043An agonist of the TRPV1 receptor. Structural analogy to Capsaicin. Local anesthetic effect is correlated with TRPV1 agonism. Demonstrates antifungal and antimicrobial effects. CAS # 97-53-0

Evodiaminesc-201479An agonist of TRPV1 with comparable activity to Capsaicin. Inhibits prostaglandin E2 synthesis, cyclooxygenase-2 induction and NF-κB activation. Inhibits iNOS protein synthesis. Demonstrates antiangiogenesis. Promotes apoptosis in U937 cells. CAS # 518-17-2

2
Farnesylthioacetic Acid (FTA)sc-200845FTA has shown potent and specifc inhibition of methyl esterification of farnesylated proteins, inhibtion of Ca2+ channels and an agonist for TRPA1, CAS # 135784-48-4

4α-Phorbol 12-myristate 13-acetatesc-2020214α-Phorbol 12-myristate 13-acetate is a non-tumor promoting phorbol ester derivative used as a negative control for PKC activation by PMA (sc-3576). CAS # 63597-44-4

GSK1016790Asc-255193GSK1016790A is a novel and potent TRPV4 channel agonist. The TRPV4 (transient receptor potential vanilloid 4) member of the TRP superfamily has been implicated in numerous physiological processes. GSK1016790A elicited Ca2+ influx in mouse and human TRPV4 expressing HEK cells (EC50 values of 18 and 2.1 nM, respectively), and evoked a dose-dependent activation of TRPV4 whole-cell currents at concentrations above 1 nM. CAS # 942206-85-1

Arvanilsc-202065Arvanil is a cannabinoid CB1 and vanilloid TRPV1 (VR) agonist that also inhibits the Anandamide transporter. CAS # 128007-31-8

HC-030031sc-203994Potent and selective TRPA1 inhibitor that antagonizes allyl isothiocyanate (AITC)- and formalin-evoked calcium influx. CAS # 349085-38-7

IBTUsc-221737Potent vanilloid receptor 1 [TRPV1] antagonist with marked selectivity for the Ca+ entry-linked receptor subpopulation of TRPV1.

JNJ 17203212sc-204024JNJ 17203212 is a high affinity transient receptor potential vanilloid 1 (TRPV1) receptor antagonist. Shown to elevates the micturition reflex threshold for activation in rodent bladder studies, and in rats weakens colonic hypersensitivity. CAS # 821768-06-3

JYL-1413sc-202192A TRPV1 channel antagonist that has been shown to bind to RTX. CAS # 735331-54-1

Capsazepinesc-201098Capsazepine is a competitive agonist of the TRPV1 (VR-1) receptor and antagonist of Capsaicin action at this receptor. Capsazepine also activates amiloride-sensitive epithelial Na+ channel ENaCδ. CAS # 138977-28-3

JYL-1433sc-202676A selective ransient receptor potential vanilloid-1 (TRPV1) antagonist. Shown to inhibit calcium flux and capsaicin toxicity in epitheliall cell studies. CAS # 565448-40-0

1
JYL-1511sc-202677A partial agonist for the TRPV1 channel. Research indicates that the presence of Cyclosporin A increases the efficiency of JYL-1511. CAS # 623166-14-3

JYL-273sc-202678Potent TRPV1 agonist (Ki=11nM). About 500-fold more potent than capsaicin . RTX binding affinity (Ki=6.35nM), agonism (calcium influx; EC50=2.83nM). CAS # 289902-71-2

JYL-79sc-221785Potent TRPV1 agonist. More potent than capsaicin with RTX binding affinity, agonism.

JYL-827sc-202193Potent TRPV1 agonist. RTX binding affinity (Ki=29.3nM), antagonism (IC50=67nM). CAS # 401572-96-1

Linvanilsc-205951TRPV1 ligand with low affinity to CB1 receptor (Kι=3.4µM). Inhibits anandamide uptake (IC50=8.0µM).

Icilinsc-201557Icilin is a small molecule agonist of the TRPM8 receptor, producing cold sensation.Icilin regulates Na+ homeostasis in cells across the epithelia through the amiloride-sensitive epithelial Na+ channel. CAS # 36945-98-9

2
(-)-Mentholsc-202705Cooling agent. Strongly activates TRPM8 (cold menthol receptor 1; CMR1) and TRPA1. CAS # 2216-51-5

1
MSK-195sc-202712Potent analgesic with EC50=0.96µg/kg in the acetic acid-induced writhing test. RTX binding affinity (Ki=603nM), agonism (calcium influx; EC50=240nM). CAS # 289902-82-5

PDNHVsc-202760Resiniferatoxin-type phorboid vanilloid with capsaicin-like selectivity for TRPV1. CAS # 251362-87-5

Polygodialsc-201489Naturally occurring sesquiterpene that displays antinociceptive and antifungal properties. Found to down-regulate TRPA1 in spinal chord. CAS # 6754-20-7

PSY-279sc-202780TRPV1 agonist. Amide based RTX analog. RTX binding affinity (Ki=15nM), high agonism (calcium influx: EC50=0.29nM). CAS # 289903-41-9

Resiniferatoxinsc-24015An irritant diterpenoid experimentally shown to release substance P from afferent nociceptive specific neurons and stimulate protein kinase C. CAS # 57444-62-9

12
RN 1734sc-296273RN 1734 is a selective TRPV4 antagonist. RN 1734 has been shown to display selectivity for over other TRP channels CAS # 946387-07-1

RN 1747sc-296274RN 1747 is a selective TRPV4 agonist. CAS # 1024448-59-6

SU-154sc-203285A TRPV1 antagonist. CAS # 681810-30-0

WS 12sc-204400Cooling agent and potent TRPM8 agonist (EC50 = 193 nM). CAS # 68489-09-8

WS 3sc-204401TRPM8 receptors agonist (EC50 = 3.7 μM) and cooling agent. CAS # 39711-79-0

N-(p-Amylcinnamoyl) anthranilic Acid (ACA)sc-200734N-(p-Amylcinnamoyl) anthranilic Acid (ACA) is an inhibitor of PLA2 and glucose-induced arachidonic acid formation that modulates the activity of different transient receptor potential channels. CAS # 110683-10-8

1
N-Arachidonoyl-serotoninsc-201460N-Arachidonoyl-serotonin is a selective fatty acid amid hydrolase (FAAH) and TRPV1 channel inhibitor. Shown to be inactive against cPLA2 and CB1. CAS # 187947-37-1

Olvanilsc-201454Olvanil is a potent agonist of the TRPV1 receptor, 10-fold more potent than Capsaicin. Also inhibits anandamide uptake and fatty acid amide hydrolase (FAAH). CAS # 58493-49-5