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Tie-2 Inhibitors

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For functional analysis of Tie-2 Inhibitors, see our complete listing of Tie-2 Antibodies.

MGCD-265sc-364533MGCD-265 is a potent, multi-target, and ATP-competitive receptor tyrosine kinase inhibitor of Met, Flt-1, Flt-4, Flk-1, Ron, and Tie-2 (IC50 = 1 nM - 7 nM). CAS # 875337-44-3

Sodium succinate dibasicsc-251053Sodium succinate dibasic is an inhibitor of multiple receptor tyrosine kinases, and is known to be a potent inhibitor of Met, Flt-1 (VEGFR1), Flk-1 (VEGFR2), Flt-3 (VEGFR3), Ron, and Tie2. CAS # 150-90-3

Tie2 Kinase Inhibitorsc-356156Tie2 Kinase Inhibitor is a cell-permeable pyridinylimidazole which has been reported to act as a potent, reversible, and ATP-binding site-targeting inhibitor of Tie2. CAS # 948557-43-5

Tie-2 Inhibitor 7sc-202363Tie-2 Inhibitor 7 is a compound that can permeate the cell (IC50= 1μM) and inhibit endothelial cell tube formation. CAS # 1020412-97-8

4,4'-Bis(4-aminophenoxy)biphenylsc-2677714,4'-Bis(4-aminophenoxy)biphenyl is known to be a potent Flk-1 (VEGFR2) inhibitor. It is also known to strongly inhibit Tie-2, Flt-1, Flt-3, Flt-4, Ret, Met (c-Met), and Axl. CAS # 13080-85-8