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Sodium Channel Modulators

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PRODUCT NAMECATALOG #DESCRIPTIONCITATIONSRANKING
5-(N-Ethyl-N-isopropyl)-Amiloridesc-202458A selective inhibitor of Na+/H+ exchange through inhibitor of the Na+/H+ antiporter protein. CAS # 1154-25-2

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5-(N-Methyl-N-isobutyl)-Amiloridesc-2029295-(N-Methyl-N-isobutyl)-Amiloride is an NHE inhibitor and possible antitumor agent. CAS # 96861-65-3

5-(N,N-Hexamethylene)amiloridesc-239021An inhibitor of Na+/H+ antiport. CAS # 1428-95-1

A 887826sc-362708 CAS # 1266212-81-0

Allethrinsc-202921Type I pyrethroid, a very weakly active "negative" control for inhibition of calcineurin (PP2B) by type II pyrethroids. CAS # 584-79-2

Amiloride, 5-(N,N-Dimethyl)-, hydrochloridesc-202459An inhibitor of the Na+-H+ exchanger with stronger potency over Amiloride. Protects against cardiac contractile dysfunction during reperfusion by normalizing tissue Na+ levels. CAS # 1214-79-5

5,5-Diphenylhydantoin sodium saltsc-2143375,5-Diphenylhydantoin sodium salt is a sodium channel protein inhibitor. CAS # 630-93-3

Batrachotoxinsc-201086A toxic steroidal alkaloid, which is found in neotropical poison dart frogs from the genus, Phyllobates. CAS # 23509-16-2

Ambroxol hydrochloridesc-200816An expectorant and mucolytic agent. Demonstrates antioxidant and antiinflammatory effects. Scavenger of hydroxyl radicals and superoxide radical anions. CAS # 23828-92-4

Benzamil hydrochloride hydratesc-252410N -Benzyl derivative of amiloride.Selective and potent blocker off Na+/H+ and Na+/Ca2+ channels. CAS # 161804-20-2 (anhydrous)

Benzamil•HClsc-201070This product is a potent sodium channel blocker. It has been shown to be capable of blocking Ca2+ transients in cardiomyocytes. CAS # 2898-76-2

BIA 2-093sc-252432Voltage-gated sodium channel blocker; significantly blocks excitatory amino acid (glutamate and aspartate) release. CAS # 236395-14-5

Brevetoxin PbTx-2, Ptychodiscus brevissc-203853Lipid-soluble polyether neurotoxin that binds to nerve and muscle Na+ channels causing an excessive influx of Na+ across membranes. Binds at site 5 on the voltage-sensitive Na+ channel. CAS # 79580-28-2

Bupivacaine Free Basesc-204657Local anesthetic which binds to the intracellular portion of sodium channels and blocks sodium influx into the nerve cells CAS # 38396-39-3

Butacaine Sulphatesc-210971 CAS # 149-15-5

Co 102862sc-203900State-dependent inhibitor of voltage-gated Na+ channels; anticonvulsant. CAS # 181144-66-1

Dihydroouabainsc-252720A cardiac glycoside and an inhibitor of the sodium-potassium pump. CAS # 1183-35-3

Disopyramidesc-207585An antiarrhythmic (class IA) and a sodium channel blocker. CAS # 3737-09-5

Disopyramide phosphate saltsc-252757A class IA antiarrhythmic and a sodium channel blocker. CAS # 22059-60-5

Deltamethrinsc-24013Deltamethrin is a type II pyrethroid insecticide that potently inhibits calcineurin with an IC50 of 10-9 to 10-11 M. CAS # 52918-63-5

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Encainide hydrochloridesc-252774This is a sodium channel blocker and class Ic antiarrhythmic. Encainide is a non-chiral antiarrhythmic and benzanilide derivative. CAS # 66794-74-9

Flecainide acetatesc-203581Cardiac Na+ channel blocker. Open Na+ channel blocker which inhibits fast cardiac muscle Na+ current in a use- and concentration-dependent manner. Orally-active class Ic antiarrhythmic agent. CAS # 54143-56-5

Grayanotoxin III Hemi(ethyl acetate)sc-201076Grayanotoxin III is a member of the Grayanotoxin family. Modulates Na+ channels and disturbs potentials, leading to Ca2+ channel flux and release of GABA and glutamates. CAS # 4678-45-9

Halofantrine hydrochloridesc-255195A blocker of delayed rectifier potassium current via the inhibition of hERG channel. CAS # 36167-63-2

Ralfinamide mesylatesc-362788Ralfinamide mesylate is a mixed sodium and N-type calcium channel protein inhibitor. CAS # 202825-45-4

Kavain (+/-)sc-201077A lipophilic kavapyrone shown to significantly antagonize dopamine depletion in murine striatal neurons. Also reported to block various cationic v-gated channels. CAS # 500-64-1

1
KB-R7943 MESYLATEsc-202681KB-R7943 mesylate is a cell permeable, potent, selective NCKX inhibitor of the reverse mode of Na+/Ca2+ exchange in cells expressing NCX1. CAS # 182004-65-5

1
KC 12291 hydrochloridesc-204028Orally active atypical voltage-gated sodium channel blocker. Inhibits sustained sodium currents (INaL) and prevents diastolic contracture in isolated atria in vitro (IC50 values are 9.6 and 0.55 - 0.79 μM respectively). Displays anti-ischemic, bradycardic and cardioprotective activity in vivo. CAS # 181936-98-1

KR-32568sc-252934Sodium/H2 exchanger-1 (NHE-1) inhibitor; inhibited NHE-1-mediated rabbit platelet swelling; in anesthetized rats, reduced infarct size from 67% (control) to 43% (at 0.1 mg/kg) and 24% (at 1.0 mg/kg); reduced number of ventricular premature beats from 530 to 266 (at 0.1 mg/kg) and 115 (at 1.0 mg/kg); reduced ventricular fibrillation incidence from 17 to 8 (0.1 mg/kg) and 0 (1.0 mg/kg); implications for research and treatment of myocardial ischemic diseases. CAS # 852146-73-7

Lamotriginesc-201079Lamotrigine is a phenyltriazine sodium channel protein inhibitor of presynaptic neurons. CAS # 84057-84-1

Lappaconitine hydrobromidesc-300905This product is a selective blocker of the TTX-sensitive Na+ channels, and does not influence on the activation threshold of Na+ channels. CAS # 97792-45-5

Lidocainesc-204056Lidocaine is a selective inverse peripheral histamine H1-receptor agonist. Lidocaine is also an anasthetic and class Ib antiarrhythmic agent. CAS # 137-58-6

Lidocaine hydrochloride hydratesc-202211Na+ channel blocker CAS # 6108-05-0

Mepivacaine hydrochloridesc-252996Local anesthetic. Reversibly blocks inward current of transient Na+, as well as the steady-state K+ outward current. Blocks tandem pore (TASK) and Kv1.5, potassium channels in model systems. CAS # 1722-62-9

Mexiletine hydrochloridesc-253048This chemical is a Class IB antiarrhythmic, as well as a sodium channel blocker. CAS # 5370-01-4

Monensin Nasc-200109A monovalent cation ionophore with specificity for Na+. Forms a lipophilic complex which freely crosses cell membranes. CAS # 22373-78-0

PD-85639sc-201084A potent and selective sodium channel blocker. It binds specifically to a local anesthetic receptor site on the Na+ channel α-subunit that is allosterically linked to neurotoxin receptor site 21. CAS # 150034-24-5

Phenamil methanesulfonate (free base)sc-202280Amiloride analog. Irreversibly blocks amiloride-sensitive Na+ channels. CAS # 2038-35-9

Procainamide hydrochloridesc-202297A blocker of Na+ channels that demonstrates antiarrhythmic effects. CAS # 614-39-1

Quinidine sulfate dihydratesc-205967A diastereomer of quinine and a Na+ channel blocker. Also a class I antiarrhythmic drug. CAS # 6591-63-5

QX 222sc-203673Na+ channel blocker CAS # 21236-55-5

QX 314 chloridesc-203674Membrane impermeable quaternary derivative of lidocaine, a voltage-activated Na+ channel blocker. CAS # 5369-03-9

QX-314sc-3579QX-314 is a quarternary lidocaine (sc-204056) derivative which acts as a local anesthetic and a strong sodium channel protein inhibitor of intracellular voltage-sensitive sodium ion conductance. CAS # 21306-56-9

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R(-)-Me5 hydriodidesc-301654A demonstrated potent sodium channel antagonist, that may be used as a sodium channel blocker in sketetal muscle.

Riluzolesc-201081Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. CAS # 1744-22-5

SDZ-201106 (-)sc-222301(-)-Enantiomer of sodium channel opener SDZ-201106. CAS # 97730-95-5 (racemic)

SDZ-201106 (+)sc-222302(+)-Enantiomer of sodium channel opener SDZ-201106. CAS # 97730-95-5 (racemic)

SDZ-201106 (±), (DPI-201106)sc-201072Sodium channel opener. Positive inotropic agent. CAS # 97730-95-5

1
Sipatriginesc-362796 CAS # 130800-90-7

Tocainide hydrochloridesc-253706This is a sodium channel blocker; Class IB antiarrhythmic. CAS # 71395-14-7

Triamterenesc-213103Diuretic, Na+ channel blocker. CAS # 396-01-0

Veratridinesc-201075An agent that opens voltage dependent Na+ channels, blocks Na+ channel activation, and induces Ca2+ influx. CAS # 71-62-5

Daidzeinsc-24001Daidzein is an inactive analogue of genistein, a tyrosine kinase inhibitor, as well as a phytoestrogen which may play a role in hormone-produced cancers. An estrogen receptor activator. CAS # 486-66-8

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Proxymetacaine Hydrochloridesc-205820Proxymetacaine Hydrochloride is a peripheral neuron voltage-gated sodium channel protein inhibitor. CAS # 5875-06-9

5,5-Diphenyl Hydantoinsc-2103855,5-Diphenyl Hydantoin is a sodium channel protein inhibitor. CAS # 57-41-0

Ibutilide Fumaratesc-211627Ibutilide Fumarate is a sodium channel protein inhibitor and methanesulfonanilide anti-arrhythmic agent that prolongs myocardial action potential duration mostly by activation of slow inward sodium current. CAS # 122647-32-9

Rufinamidesc-212794Rufinamide CAS # 106308-44-5