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PRODUCT NAMECATALOG #DESCRIPTIONCITATIONSRANKING
1-Norokadaonesc-287172Shown to exhibit inhibitory effects on Serine/Threonine Phosphatases and potential use as an okadaic acid negative control. CAS # 131204-29-0

8-MA-cAMPsc-257017A selective cAMP-dependent protein kinase (PKA) activator and a site selective cyclic AMP analog with a similar affinity to site B of both protein kinase A type I and II. A priming analog which acts synergistically together with analogs showing site A preference. Together with e.g. 8-piperidino cAMP, selective stimulation of type I can be achieved CAS # 33823-18-6

8-PIP-cAMPsc-257021A selective cAMP-dependent protein kinase (PKA) activator which is a site selective cyclic AMP analog with high selectivity for the site A of protein kinase A type I and site B of type II. Acts synergistically together with analog having opposite site-selectivity. CAS # 31357-06-9

AD 198sc-252351A PKC-delta activator. Phospholipid scramblase 3 (PLS3) is an enzyme which plays a crucial role in mitochondrial morphology, functions, and apoptotic response. During apoptosis, activated protein kinase C-delta (PKC-delta) translocates to mitochondria and phosphorylates PLS3. Used to show that PLS3 is a critical downstream effector of PKC-delta in AD 198-induced apoptosis. CAS # 98983-21-2

Akt1/2 kinase inhibitorsc-300173An Isozyme selective Akt1/2 kinase inhibitor.

CKI-7 dihydrochloridesc-252621A CK1 inhibitor which also inhibits SGK, S6K1 and MSK1. Inhibits SGK as potently as CK1. CAS # 1177141-67-1

DCP-LAsc-255068DCP-LA is a selective PKCε activator. CAS # 28399-31-7

Guanosine 3',5'-cyclic monophosphorothioate, Rp Isomer triethylammonium saltsc-252867cGMPS-dependent protein kinase Iå inhibitor. CAS # 86562-09-6

KRIBB3sc-252935An inhibitior of PKC-dependent phosphorylation of Hsp27 through its direct binding to Hsp27. Has antimigratory and anti-invasive activities in MDA-MB-231 cells. KRIBB3 blocked phorbol 12-myristate 13-acetate-induced phosphorylation of Hsp27 and tumor cell migration. CAS # 129414-88-6

Methyl Okadaatesc-295454Serine/Threonine protein phosphatase inhibitor CAS # 78111-14-5

Okadaic Acid, Potassium Saltsc-202261An inhibitor of PP1, PP2A, PP2B, PP2C and endogenous phosphatase smooth muscle myosin. Additionally used to study tumor promotion, nitric oxide metabolism, apoptosis, cell cycling and calcium signaling. CAS # 155751-72-7

Staurosporinesc-3510Staurosporine inhibits PKC and most other kinases, including tyrosine kinases; binds to ATP binding domain; inhibits topoisomerase II. CAS # 62996-74-1

16
SB 220025 trihydrochloridesc-253537A potent, specific inhibitor of human p38 mitogen-activated protein (MAP) kinase. CAS # 197446-75-6

SB 431542 hydratesc-255604A potent and selective inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors. CAS # 301836-41-9 (anhydrous)

SB-505124sc-362794SB-505124 is an inhibitor of activin receptor-like kinase (ALK-5). SB-505124 is demonstrated to suppress the action of transforming growth factor-B (TGF-B) both in vitro and in vivo. CAS # 694433-59-5

SB-505124 hydrochloride hydratesc-253542Selective inhibitor of transforming growth factor-β type I receptor CAS # 694433-59-5 (non-salt)

SIS3 hydrochloridesc-253565A specific inhibitor of Smad3 phosphorylation via inhibiting the effects of TGF-β1. Reestablishes myofibroblast differentiation of scleroderma fibroblasts via reducing expression of α-SMA. CAS # 521984-48-5

SMER28sc-222320SMER28 is small molecule modulator of mammalian autophagy. CAS # 307538-42-7

Sp-8-pCPT-cAMPSsc-253602A selective cAMP-dependent protein kinase (PKA) activator. Vial of 5 μmol. CAS # 129693-13-6 (non-salt)