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PRODUCT NAMECATALOG #DESCRIPTIONCITATIONSRANKING
1-(7-Carboxyheptyl)imidazolesc-205915Selective inhibitor of thromboxane synthetase. CAS # 68887-68-3

13,14-epoxy Travoprostsc-287303An impurity generated in the production of fluprostenol isopropyl ester.

16,16-Dimethyl-prostaglandin E2sc-20124016,16-Dimethyl-prostaglandin E2 is a prostaglandin E2 analog with potent cytoprotective activity and enhanced metabolic resistance yielding a longer half-life in vivo. Acts on all 4 EP receptors (EP1,2,3, and 4). CAS # 39746-25-3

cis-5,8,11,14,17-Eicosapentaenoic acid sodium saltsc-214735cis-5,8,11,14,17-Eicosapentaenoic acid sodium salt inhibits 5-LO (5-lipoxygenase) and reduces thromboxane A2 production. CAS # 73167-03-0

17-Phenyl-trinor-prostaglandin E2sc-20125517-Phenyl-trinor-prostaglandin E2 is a synthetic analog of PGE2 (sc-201225), found to be a selective EP1 and EP3 receptor agonist, unlike PGE2 which antagonizes a variety of EP receptors. CAS # 38315-43-4

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AA 2414sc-203796Thromboxane A2 (TP) receptor antagonist. Antiasthmatic agent; inhibits platelet aggregation and bronchoconstriction induced by a TXA2 mimetic in guinea pigs. CAS # 112665-43-7

AL 6598sc-358796Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins such as PGF2α and PGD2, have been shown to reduce IOP. AL 6598 is the isopropyl ester prodrug of AL 6556, a PGD2 receptor agonist that binds to DP receptors with a Ki value of 3.2 µM and demonstrates an EC50 value of 0.80 µM in an in vitro functional assay. Designed to enhance corneal absorption, AL 6598 produces a maximum 53% drop in IOP of the ocular hypertensive monkey with a 1 µg dose given twice daily. CAS # 170291-06-2

BAY-u 3405sc-203834Suppresses PGD2-induced migration of human eosinophils (IC50 = 170 nM). Potent dual antagonist of TP/DP2 (CRTH2) prostanoid receptors (Ki values are 4.3, 4.5 and > 10000 nM for hDP2, hTP and hDP1 receptors respectively). CAS # 116649-85-5

Cloprostenol Sodiumsc-201338Cloprostenol Sodium is a synthetic F series prostaglandin that functions as a potent agonist towards the PGF2alphaR (FP receptor). CAS # 55028-72-3

Fluprostenolsc-201336Fluprostenol is a PGF2αR (prostaglandin F (FP) receptor) agonist that is more selective than PGF2α (sc-201227). CAS # 40666-16-8

GW 627368Xsc-221702A selective and potent competitive antagonist of the EP4 receptor with additional human TP receptor affinity. CAS # 439288-66-1

L-655,240sc-201350L-655,240 is a potent inhibitor of contractions induced by prostaglandin endoperoxide analogs. Also reported to be an inhibitor of TXA2R (thromboxane receptors). CAS # 103253-15-2

L-670,596sc-204041An orally active potent and selective thromboxane A2/prostaglandin endoperoxide receptor antagonist. Inhibits human platelet aggregation in vitro and the U-44069-induced contractions of guinea-pig trachea. Also prevents thromboxane-mediated endothelial cell death. CAS # 121083-05-4

L-798,106sc-204047Potent and highly selective prostanoid EP3 receptor antagonist (Ki values are 0.3, 916, > 5000 and > 5000 nM at EP3, EP4, EP1 and EP2 respectively). Attenuates sulprostone-induced inhibition of EFS-evoked twitch and contractile responses in vivo. CAS # 244101-02-8

Latanoprostsc-201354Latanoprost is a prodrug (isopropyl ester) of 17-phenyl-13,14-dihydro prostaglandin F2α. The free acid form is a potent agonist at PGF2αR (FP receptors). CAS # 130209-82-4

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Misoprostol (SC-29333)sc-201264Misoprostol (SC-29333) is a synthetic E prostaglandin that has been shown to prevent tissue corrosion induced by certain anti-inflammatory compounds. Shown to have negative effects on the murine nervous system. CAS # 59122-46-2

Ozagrel hydrochloridesc-204153Potent and selective inhibitor of thromboxane (TXA2) synthetase (IC50 = 4 nM). Does not inhibit prostacyclin (PGI2) synthetase, cyclooxygenase or PGE2 isomerase (IC50 > 1 mM). Inhibits platelet aggregation in vitro and arachidonate-induced arterial contraction in vivo. CAS # 74003-18-2

Picotamidesc-201334Picotamide is a dually active TXA2R (thromboxane A2) and TXA synthase (thromboxane A2 synthase) inhibitor. It has been shown to exhibit platelet inhibitory effects ex vivo and in vitro. CAS # 32828-81-2

SC-51089sc-201344A selective antagonist of prostaglandin E2, which displays specificity towards the EP1 receptor subtype. This compound contains a diacylhydrazine moiety, which has often been observed to release hydrazine. CAS # 146033-02-5

SC-51322sc-205848A potent and selective prostaglandin E2 antagonist (pA2=8.1). Displays in vivo analgesic activity in the mouse (ED50=0.9 mg/kg)1.

Seratrodastsc-201352Seratrodast is a potent selective TXA2R (thromboxane A2 receptor) antagonist with antioxidant effects. Inhibits peroxide-induced vasoconstriction in human placenta and bronchoconstriction in guinea pigs. CAS # 112665-43-7

SQ-29548sc-201332A compound that reversibly and competitively acts as a thromboxane A2/prostraglandin endoperoxide receptor antagonist. CAS # 98672-91-4

Sulprostonesc-201348A metabolism-resistant synthetic analog of PGE2, that is a selective EP3 prostanoid receptor agonist. Shown to be a potent stiumulator of uterine smooth muscle contractions. CAS # 60325-46-4

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