Potassium Channel Modulators

1-EBIO
Activates epithelial K/Ca channels; stimulates a large and sustained trans-epithelial Cl- secretory response across T84 monolayers. Induces hyperpolarization in aortic value endothelial cells.
Catalog # CAS Number Molecular Formula Unit
sc-201695 10045-45-1 C₉H₁₀N₂O 10 mg/50 mg
(-)-[3R,4S]-Chromanol 293B
Catalog # CAS Number Molecular Formula Unit
sc-361081 163163-24-4 C₁₅H₂₀N₂O₄S 10 mg/50 mg
5-(4-Phenoxybutoxy)psoralen
Selective inhibitor of Kv1.3, voltage-gated potassium channel. PAP-1 (EC₅₀=2 nM) potently inhibits human T effector memory cell proliferation and delayed hypersensitivity. Effective orally or intraperitoneally. 5-(4-Phenoxybutoxy)psoralen has 23-fold selectivity for Kv1.3 over Kv1.5, and 33-125-fold selectivity over other Kv1 family channels.
Catalog # CAS Number Molecular Formula Unit
sc-252247 870653-45-5 C₂₁H₁₈O₅ 5 mg
5-Hydroxydecanoate Na
A substrate for mitochondrial outer membrane acyl-CoA synthetase that inhibits ATP-sensitive K⁺ channels.
Catalog # CAS Number Molecular Formula Unit
sc-200992 624-00-0 C₁₀H₁₉O₃ ·Na 100 mg/500 mg
Adenosine 5'-O-(3-thiotriphosphate), tetralithium salt
An unhydrolyzable analogue of ATP which acts as an agonist for P2X2-R, activating calcium channels causing an influx of Ca²⁺ inside the cell.
Catalog # CAS Number Molecular Formula Unit
sc-202039 93839-89-5 C₁₀H₁₂N₅O₁₂P₃S ·4Li 1 mg/5 mg
Adenosine 5'-Triphosphate, disodium salt
A p2 purinergicagonist, increases activity of Ca²⁺ activated K⁺ channels. Induces a dose-dependant release of histamine and prostaglandin D2 from rat peritoneal mast cells.
Catalog # CAS Number Molecular Formula Unit
sc-202040 987-65-5 C₁₀H₁₄N₅O₁₃P₃ ·2Na 1 g/5 g
Adenylyl-imidodiphosphate, Tetralithium Salt
A non-hydrolyzable ATP analog that acts as a competitive inhibitor of ATP-dependent enzyme systems. Known to block ATP-sensitive Ca²⁺ activated K⁺ channels.
Catalog # CAS Number Molecular Formula Unit
sc-203805 72957-42-7 C₁₀H₁₅N₆O₁₃P₃ ·4Li 25 mg
Alinidine
Alinidine is an HCN Channel blocker of neuronal Ih, related cardiac If channels and ATP-sensitive Kir channels. It is an analog of clonidine; bradycardic and antiarrhythmic agent (sinus tachyarrhythmias). Alinidine affects physiological markers in conscious dogs. Alinidine in four intravenous (i.v.) injections of 0.5, 0.5, 1, and 2 mg/kg, decreased sinus rate (< or = 43%) and ventricular rate (< or = 44%), but increased atrial rate (< or = 31%). It lengthened CSRT (< or = 71%) at the two highest doses and increased AERP (< or = 33%) and decreased WP (< or = 33%) at all doses. Alinidine did not modify mean blood pressure at any dose in either group. These results indicate that alinidine exhibits electrophysiologic effects in conscious dogs that reflect the marked antiarrhythmic potential of this agent, apart from its assumed antiischemic properties.
Catalog # CAS Number Molecular Formula Unit
sc-252357 33178-86-8 C₁₂H₁₃Cl₂N₃ 10 mg
α-Dendrotoxin
A compound originally isolated from Dendroaspis angusticeps that has been shown to mediate voltage-gated-K⁺ channels.
Catalog # CAS Number Molecular Formula Unit
sc-252333 74504-53-3 N/A .1 mg
AM 92016 hydrochloride
A specific blocker of the time dependent delayed rectifier potassium current, devoid of any β-adrenoceptor blocking activity. Exhibits prohypertensive and proarrhythmic activity in vivo.
Catalog # CAS Number Molecular Formula Unit
sc-203506 178894-81-0 C₁₉H₂₄Cl₂N₂O₄S•HCl•xH₂O 10 mg/50 mg
Apamin
Caution! Highly toxic. Handle with care. Apamin is a potent (1-10 nM) and highly selective inhibitor of the low conductance Ca²⁺-activated K⁺ channel.
Catalog # CAS Number Molecular Formula Unit
sc-200994 24345-16-2 C₇₉H₁₃₁N₃₁O₂₄S₄ 500 µg/1 mg
Aprindine hydrochloride
Aprindine hydrochloride is a class Ib antiarrhythmic and hERG channel blocker. Aprindine shows structure similarities to lidocaine and procainamide and is effective in treatment of patients with ventricular premature depolarizations, ventricular tachycardia, and supraventricular arrhythmias. Aprindine inhibits the activation of bovine brain cyclic 3':5'-nucleotide phosphodiesterase (EC 3.1.4.17) by calmodulin and inhibits calmodulin-stimulated Ca-ATPase (ATP phosphohydrolase EC 3.6.1.3) activity.
Catalog # CAS Number Molecular Formula Unit
sc-252383 33237-74-0 C₂₂H₃₀N₂•HCl 10 mg
BL-1249
Putative activator of potassium TREK-1 channel
Catalog # CAS Number Molecular Formula Unit
sc-252498 18200-13-0 C₁₇H₁₇N₅ 10 mg
BMS 191011
Opener of the cloned large-conductance, Ca²⁺-activated potassium (maxi-K) channel. Neuroprotectant in two distinct animal models of stroke (MCAO in the SHR rat and a normotensive model of focal stroke).
Catalog # CAS Number Molecular Formula Unit
sc-203847 202821-81-6 C₁₆H₁₀ClF₃N₃O₃ 10 mg/50 mg
Charybdotoxin
A potent and selective inhibitor of the large conductance Ca²⁺ -activated K⁺ channels.
Catalog # CAS Number Molecular Formula Unit
sc-200979 95751-30-7 C₁₇₆H₂₈₉N₅₇O₅₆S₇ 100 µg
Chromanol 293B
Blocker of the slow delayed rectifier K⁺ current via KCNQ1 channels. Also blocks CFTR chloride current.
Catalog # CAS Number Molecular Formula Unit
sc-203889 163163-23-3 C₁₅H₂₀N₂O₄S 10 mg/50 mg
Clofilium tosylate
A quaternary ammonium compound that acts as potassium channel blocker.
Catalog # CAS Number Molecular Formula Unit
sc-203001 92953-10-1 C₂₁H₃₇ClN•C₇H₇O₃S 25 mg/100 mg
CP 339818 hydrochloride
Non-peptide, inhibits Kv1.3 in a use-dependent manner by preferentially blocking the C-type inactivated state of the channel. Appears to recognize only the inactivated conformation of Kv1.3
Catalog # CAS Number Molecular Formula Unit
sc-203903 185855-91-8 C₂₁H₂₄N₂ ·HCl 10 mg/50 mg
CP-339818
Blocks both Kv1.3 and Kv1.4. Kv1.3 is expressed in the brain and in effector memory Tem (T) cells, and Kv1.4 is expressed in brain cells. Kv1.3 and Kv1.4 are members of the Shaker family of voltage-gated potassium channels. Both channels are involved in setting the membrane potential of neurons. Kv1.3 also maintains the membrane potential for T memory cells and is up-regulated upon T cell activation, contributing to multiple immune processes and disorders. Blockers of Kv1.3 have long been sought for therapeutic benefit, and they are also valuable tools for studying the immune system. CP-339818 is valuable for immune system studies, where the absence of Kv1.4 makes it functionally selective for Kv1.3, and it has shown suppression of T cell activation. CP-339818 is also valuable for the study of Kv1.4 function.
Catalog # CAS Number Molecular Formula Unit
sc-252641 478341-55-8 C₂₁H₂₄N₂•HCl 5 mg
(+/-)-Cromakalim
Catalog # CAS Number Molecular Formula Unit
sc-217958 94470-67-4 C₁₆H₁₈N₂O₃ 25 mg
CyPPA
CyPPA is an activator of small conductance Ca²⁺-activated K⁺ channels. Selective for SK2 and SK3 channels, no selectivity for SK1 and IK channels.
Catalog # CAS Number Molecular Formula Unit
sc-205281 73029-73-9 C₁₆H₂₃N₅ 10/50 mg
Dequalinium chloride hydrate
A selective blocker of apamin-sensitive K⁺ channels.
Catalog # CAS Number Molecular Formula Unit
sc-214869 522-51-0 (anhydrous) C₃₀H₄₀Cl₂N₄•xH₂O 5 g
Diazoxide
A benzothiadiazine derivative which functions as a selective ATP-dependent K⁺ channel activator and calcium channel blocker.
Catalog # CAS Number Molecular Formula Unit
sc-200980 364-98-7 C₈H₇ClN₂O₂S 1 g
DMP 543
Potent neurotransmitter release enhancer, K⁺ channel blocker, and acetylcholine release stimulator. Potential Alzheimer’s disease therapeutic.
Catalog # CAS Number Molecular Formula Unit
sc-203926 160588-45-4 C₂₆H₁₈F₂N₂O 10 mg/50 mg
DPO-1
Blocker of Kv1.5 channel and IKur ultrarapid delayed rectifier potassium current. (IC₅₀ = 0.31 μM for rKV1.5). Displays selectivity for inhibition of IKur over Ito (8-fold), IK1, IKr and IKs (20-fold) in native myocytes and selectivity for rat recombinant KV1.5 over KV3.1 (~ 15-fold). Increases action potential duration in atrial but not ventricular myocytes and prevents atrial arrhythmia.
Catalog # CAS Number Molecular Formula Unit
sc-203570 43077-30-1 C₂₂H₂₉OP 10 mg/50 mg
E-4031 dihydrochloride
K⁺ channel blocker. Blocks the human ether-a-go-go-related gene (HERG) at all pulse frequencies without significant rest.
Catalog # CAS Number Molecular Formula Unit
sc-203034 113559-13-0 C₂₁H₂₇N₃O₃S ·2HCl ·2H₂O 5 mg
Gabapentin-lactam
Demonstrates a neuroprotective capacities via opening of ATP-sensitive potassium channels. Also shown to reduce oxygen glucose deprivation-induced [3H]glutamate release in vivo.
Catalog # CAS Number Molecular Formula Unit
sc-201003 64744-50-9 C₉H₁₅NO 50 mg/250 mg
Gliclazide
Sulfonylurea hypoglycemic agent used as an antidiabetic.
Catalog # CAS Number Molecular Formula Unit
sc-211561 21187-98-4 C₁₅H₂₁N₃O₃S 1 g
Glyburide (Glibenclamide)
A sulfonylurea compound shown to bind to ATP-dependent K⁺channels. Stimulates insulin release in pancreatic beta cells.
Catalog # CAS Number Molecular Formula Unit
sc-200982 10238-21-8 C₂₃H₂₈ClN₃O₅S 1 g/5 g
GW 542573X
Catalog # CAS Number Molecular Formula Unit
sc-362741 660846-41-3 C₁₉H₂₈N₂O₅ 10 mg/50 mg
ICA 069673
Catalog # CAS Number Molecular Formula Unit
sc-362745 582323-16-8 C₁₁H₆ClF₂N₃O 10 mg/50 mg
Isopimaric Acid
Potently opens large conductance Ca-activated K⁺ channels.
Catalog # CAS Number Molecular Formula Unit
sc-269270 5835-26-7 C₂₀H₃₀O₂ 5 mg
Kaliotoxin
Catalog # CAS Number Molecular Formula Unit
sc-362754 145199-73-1 C₁₇₁H₂₈₃N₅₅O₄₉S₈ 10 µg
L-364,373
Activator of KCNQ1 (KVLQT1) channels; activates the cardiac IKs current that decreases action potential duration (APD) in cardiac myocytes.
Catalog # CAS Number Molecular Formula Unit
sc-204036 103342-82-1 C₂₅H₂₀FN₃O 10 mg/50 mg
Levcromakalim
Catalog # CAS Number Molecular Formula Unit
sc-361230 94535-50-9 C₁₆H₁₈N₂O₃ 10 mg/50 mg
Linopirdine dihydrochloride
Blocker of KCNQ voltage-gated potassium channels; blocks KCNQ2+3/M-currents (IC₅₀ = 4-7 μM) and KCNQ1 homomeric channels (IC₅₀ = 8.9 μM). Increases hippocampal ACh release and is a cognitive enhancer following oral administration in vivo.
Catalog # CAS Number Molecular Formula Unit
sc-204058 105431-72-9 C₂₆H₂₁N₃O ·2HCl 10 mg/50 mg
Margatoxin, Recombinant
Catalog # CAS Number Molecular Formula Unit
sc-358754 145808-47-5 C₁₇₈H₂₈₆N₅₂O₅₀S₇ 10 µg
Minoxidil (U-10858)
A selective ATP dependent vasodilator and K⁺ channel activator. Activates the β-catenin pathway in human dermal papilla cells.
Catalog # CAS Number Molecular Formula Unit
sc-200984 38304-91-5 C₉H₁₅N₅O 100 mg/500 mg
Minoxidil sulfate (U-58838)
A K⁺ channel agonist and a strong vascular smooth muscle relaxant. It can relax norepinephrine contraction, and is reported to be a vasodilator.
Catalog # CAS Number Molecular Formula Unit
sc-200987 83701-22-8 C₉H₁₅N₅O₄S 5 mg/25 mg
Mitiglinide Calcium
Thought to stimulate insulin secretion by closing the ATP-sensitive K(+) K(ATP) channels in pancreatic beta-cells.
Catalog # CAS Number Molecular Formula Unit
sc-204808 145375-43-5 (C₁₉H₂₄NO₃)₂ ·• Ca 100 mg/250 mg
N-Salicyloyltryptamine
An activator of calcium-activated K⁺ channels which acts as an anticonvulsant and neuroprotectant.
Catalog # CAS Number Molecular Formula Unit
sc-253124 31384-98-2 C₁₇H₁₆N₂O₂ 5 mg
Nicorandil
A K(ATP) channel opener. Stimulates guanylyl cyclase and increases cyclic GMP levels. Upregulates eNOS expression. NO donor.
Catalog # CAS Number Molecular Formula Unit
sc-200995 65141-46-0 C₈H₉N₃O₄ 50 mg
NS 1643
hERG K⁺ channel activator. Displays different molecular mechanisms of action at hERG1 and hERG2 channels. Exhibits antiarrhythmic activity in vitro.
Catalog # CAS Number Molecular Formula Unit
sc-204135 448895-37-2 C₁₅H₁₀F₆N₂O₃ 10 mg/50 mg
NS 5806
Catalog # CAS Number Molecular Formula Unit
sc-362773 426834-69-7 C₁₆H₈Br₂F₆N₆O 10 mg/50 mg
NS-1619
A selective large conductance calcium activated potassium channel activator.
Catalog # CAS Number Molecular Formula Unit
sc-200986 153587-01-0 C₁₅H₈F₆N₂O₂ 5 mg
NS8593 hydrochloride
Catalog # CAS Number Molecular Formula Unit
sc-253203 875755-24-1 C₁₇H₁₇N₃•HCl 5 mg
P1075
Potent KATP channel opener (EC50 for relaxation of rat aorta = 7.5 nM). Binds to SUR2A and SUR2B with high affinity (Kd values are 17 and 3 nM respectively).
Catalog # CAS Number Molecular Formula Unit
sc-203657 60559-98-0 C₁₂H₁₇N₅ 10 mg/50 mg
Paxilline
An indole alkaloid which selectively and reversibly blocks the high conductance Ca²⁺-activated K⁺ channel; enhances binding of Charybdotoxin to maxi-K channels.
Catalog # CAS Number Molecular Formula Unit
sc-3588 57186-25-1 C₂₇H₃₃NO₄ 5 mg/25 mg
Paxillinol
A negative control for the maxi-K channel inhibitor paxilline (50% block at 0.1-1 µM)1.
Catalog # CAS Number Molecular Formula Unit
sc-205792 N/A C₂₇H₃₅NO₄ 2 mg
PCO 400
This product is an analog of comakalim and a selective and potent ATP-sensitive K⁺ channel opener.
Catalog # CAS Number Molecular Formula Unit
sc-200989 121055-10-5 C₁₇H₁₇NO₄ 20 mg/100 mg
PD-118057
An activator of ether-a-go-go-related (hERG) potassium channel. It is a second identified hERG channel activator, a representative in the series of structural analogs; PD-118057 at 10 µM leads to a 111% current increase in rabbit ventricular wedge (in comparison RPR260243 leads to only a 15% increase at the same concentration). PD-118057, unlike RPR260243, does not have a major effect on gating or kinetic properties of this channel. This chemical prevents and reverses QT interval prolongation. Compounds such as PD-118057 may offer a new approach in the treatment of delayed repolarization conditions, which occur in inherited or acquired long QT syndrome and congestive heart failure.
Catalog # CAS Number Molecular Formula Unit
sc-253238 313674-97-4 C₂₁H₁₇Cl₂NO₂ 5 mg
Penitrem A
A potent neurotoxin that has been shown to have numerous effects on ion channels and neurotransmitter release. Can also induce an increase in the voltage and frequency of cerebral cortex electrical activity.
Catalog # CAS Number Molecular Formula Unit
sc-200997 12627-35-9 C₃₇H₄₄ClNO₆ 1 mg/5 mg
Pinacidil
An opener of K⁺ channels. Induces relaxation of serotonin-produced contractions of arterial tissue through opening of ATP-dependent K⁺ channels.
Catalog # CAS Number Molecular Formula Unit
sc-203198 85371-64-8 C₁₃H₁₉N₅ ·H₂O 10 mg/50 mg
Potassium dicyanoargentate
Dicyanoargentate ion is a versatile bridging ligand that has application for constructing multidimensional polymers.
Catalog # CAS Number Molecular Formula Unit
sc-253300 506-61-6 C₂AgKN₂ 10 g
Psora-4
The lymphocyte potassium channel Kv1.3 is a new target for immunosuppression. This is the most potent small-molecule Kv1.3 blocker known. It blocked Kv1.3 in a use-dependent manner, with a Hill coefficient of 2 and an EC₅₀ value of 3 nM, by preferentially binding to the C-type inactivated state of the channel. It exhibited 17- to 70-fold selectivity for Kv1.3 over closely related Kv1-family channels (Kv1.1, Kv1.2, Kv1.4, and Kv1.7) with the exception of Kv1.5 (EC₅₀, 7.7 nM) and showed no effect on human ether-a-go-go-related channel, Kv3.1, the calcium-activated K⁺ channels (IKCa1, SK1-SK3, and BKCa), or the neuronal NaV1.2 channel. In a test of in vivo toxicity in rats, Psora-4 did not display any signs of acute toxicity after five daily subcutaneous injections at 33 mg/kg body weight. Psora-4 selectively suppressed the proliferation of human and rat myelin-specific effector memory T cells with EC₅₀ values of 25 and 60 nM, respectively, without persistently suppressing peripheral blood naive and central memory T cells. Because autoantigen-specific effector memory T cells contribute to the pathogenesis of T cell-mediated autoimmune diseases such as multiple sclerosis, Psora-4 and other Kv1.3 blockers may be useful as immunomodulators for the therapy of autoimmune disorder.
Catalog # CAS Number Molecular Formula Unit
sc-253325 724709-68-6 C₂₁H₁₈O₄ 5 mg
Quinine hemisulfate
Stereoisomer of quinidine. Plant alkaloid with a broad spectrum of biological effects including anti-cholinergic, hypoglycemic and antimalarial properties. K⁺ channel blocker.
Catalog # CAS Number Molecular Formula Unit
sc-202305 6119-70-6 C₂₀H₂₄N₂O₂ ·0.5H₂SO₄ 10 g
Quinine hydrochloride dihydrate
Potassium channel blocker
Catalog # CAS Number Molecular Formula Unit
sc-212619 6119-47-7 C₂₀H₂₄N₂O₂•HCl•2H₂O 5 g/25 g
R-(+)-DIOA
Inhibitor of the K⁺/Cl^--cotransport that does not affect the bumetanide-sensitive Na⁺/K⁺/Cl^--cotransport system
Catalog # CAS Number Molecular Formula Unit
sc-203230 81166-47-4 C₂₀H₂₄Cl₂O₄ 5 mg/25 mg
Retigabine Dihydrochloride
A KCNQ/Kv7 potassium channel activator which functions by enhancing potassium currents via stabilizing the open conformation of the Kv7.2-7.3 channels.
Catalog # CAS Number Molecular Formula Unit
sc-212772 150812-13-8 C₁₆H₁₈FN₃O₂•2HCl 10 mg
Sematilide monohydrochloride monohydrate
A class III antiarrhythmic compound showing selective delayed rectifier K⁺ current channel blocking. It has been shown to inhibit rapidly activating lk in atrial myocytes in guinea pigs. This results in the prolongation of AP duration and refractor capacity. Has exhibited proarrhythmic effects, potentailly leading to QT interval prolongation.
Catalog # CAS Number Molecular Formula Unit
sc-253550 101526-62-9 (non-salt) C₁₄H₂₃N₃O₃S··HCl•H₂O 50 mg
SG 209
K⁺ channel opener. Nitrate-free coronary vasodilator, analog of nicorandil.
Catalog # CAS Number Molecular Formula Unit
sc-204276 83440-03-3 C₁₀H₁₂N₂O₃ 10 mg/50 mg
Tertiapin LQ
Catalog # CAS Number Molecular Formula Unit
sc-362807 N/A C₁₀₆H₁₇₉N₃₃O₂₄S₄ 1 mg
Tetracaine hydrochloride
A topical ophthalmic anesthetic which is used for spinal anesthesia Blocks voltage-sensitive release of Ca(2+) from sarcoplasmic reticulum.
Catalog # CAS Number Molecular Formula Unit
sc-251166 136-47-0 C₁₅H₂₄N₂O₂•HCl 5 g/25 g
Tolbutamide
An agonist for secretion of islet hormones somatostatin, insulin and glucagon and for proliferation beta-cells in the presence of calcium in hypoglycemic conditions.
Catalog # CAS Number Molecular Formula Unit
sc-203298 64-77-7 C₁₂H₁₈N₂O₃S 5 g
Tolfenamic Acid
Non steroidal anti-inflammatory agent found to inhibit COX-2 isoenzymes in dogs. Its analgesic property is due to activation of Ca²⁺ -activated K⁺ channels.
Catalog # CAS Number Molecular Formula Unit
sc-204918 13710-19-5 C₁₄H₁₂ClNO₂ 5 g/25 g
TRAM-34
Shown to inhibit IK1 channels in human T lymphocytes. This inhibition has been reported to modulate cell proliferation in a concentration dependent manner.
Catalog # CAS Number Molecular Formula Unit
sc-201005 289905-88-0 C₂₂H₁₇ClN₂ 5 mg/25 mg
U-37883A
U-37883A is a potent inhibitor of vascular smooth muscle K-ATP channels.
Catalog # CAS Number Molecular Formula Unit
sc-201001 57568-80-6 C₂₁H₃₅N₃O··HCl 5 mg/25 mg
UCL 1684
Catalog # CAS Number Molecular Formula Unit
sc-361390 199934-16-2 C₃₄H₃₀N₄•2Br 5 mg
UCL 1684 ditrifluoroacetate hydrate
A potent, non-peptide blocker of the apamin-sensitive Ca²⁺-activated K⁺ channel.
Catalog # CAS Number Molecular Formula Unit
sc-253818 201147-19-5 (anhydrous) (C₃₄H₃₀N₄)₂+•(C₂F₃O₂-)2•xH₂O 5 mg
UCL 2077
Slow afterhyperpolarization (sAHP) channel blocker that reduces sAHP in hippocampal slice preparations. Displays no effect on the time course of sAHP/sIAHP or Ca²⁺ currents.
Catalog # CAS Number Molecular Formula Unit
sc-204371 918311-87-2 C₂₅H₂₂N₂ 10 mg/50 mg
UCL-1848 trifluoroacetate salt
A selective, Ca²⁺-activated, SK potassium channel blocker.
Catalog # CAS Number Molecular Formula Unit
sc-253819 201147-53-7 C₃₂H₃₄F₆N₄O₄•xC₂HF₃O₂ 5 mg
UK 78282 hydrochloride
Catalog # CAS Number Molecular Formula Unit
sc-361395 136647-02-4 C₂₉H₃₅NO₂.HCl 10 mg/50 mg
UK-78282 monohydrochloride
UK-78282 blocks Kv1.3 and Kv1.4, which are members of the Shaker family of voltage-gated potassium channels. Kv1.3 is expressed in brain and effector memory T (Tem) cells, and Kv1.4 is expressed in brain. Both channels are involved in setting the membrane potential of neurons. Kv1.3 also maintains the membrane potential for T memory cells and is up-regulated upon T cell activation, contributing to multiple immune processes and disorders. Blockers of Kv1.3 have long been sought for therapeutic benefit, and they are also valuable tools for studying the immune system. Selective blockers of Kv1.4 are desired, as there are few if any currently available. UK-78282 is valuable for immune system studies, where the absence of Kv1.4 makes it functionally selective for Kv1.3, and it has shown suppression of T cell activation. UK-78282 is also valuable for the study of Kv1.4 function.
Catalog # CAS Number Molecular Formula Unit
sc-253820 136647-02-4 C₂₉H₃₅NO₂ ·HCl 5 mg
Verruculogen
Neurotoxin that inhibits the M phase of the mammalian cell cycle. Inhibits Ca²⁺ -activated K⁺channels. Decreases GABA levels in CNS.
Catalog # CAS Number Molecular Formula Unit
sc-204939 12771-72-1 C₂₇H₃₃N₃O₇ 1 mg/5 mg
XE 991 dihydrochloride
Potent and selective blocker of KCNQ voltage-gated potassium channels. Blocks KCNQ2+3/M-currents and KCNQ1 homomeric channels but is less potent against KCNQ1/minK channels.
Catalog # CAS Number Molecular Formula Unit
sc-203453 122955-42-4 C₂₆H₂₀N₂O ·2HCl 10 mg/50 mg
Y-26763
KATP channel opener and active metabolite of Y-27152. In vitro, causes relaxation of contracted rat aortic rings (IC₅₀ = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic b-cells. In vivo, produces hypotension in spontaneously hypertensive rats and shows cardioprotective properties in dogs following systemic administration.
Catalog # CAS Number Molecular Formula Unit
sc-204406 127408-31-5 C₁₄H₁₆N₂O₄ 10 mg/50 mg
Y-27152
Prodrug of the KATP channel opener Y-26763. Inactive in vitro; fails to modify tension in contracted aortic rings at concentrations up to 1 mM. Orally active in vivo, produces long-lasting antihypertensive effects with minimal tachycardia following oral administration in hypertensive animals.
Catalog # CAS Number Molecular Formula Unit
sc-204407 127408-30-4 C₂₁H₂₂N₂O₄ 10 mg/50 mg
YS-035 hydrochloride
Ca²⁺ blocker that prolongs cardiac action potentials through inhibition of pacemaker current and outward K⁺ currents.
Catalog # CAS Number Molecular Formula Unit
sc-203722 33978-72-2 C₂₁H₂₉NO₄ ·HCl 10 mg/50 mg
ZM 226600
A selective KATP channel opener.
Catalog # CAS Number Molecular Formula Unit
sc-281189 147695-92-9 C₁₆H₁₄F₃NO₄S 10 mg/50 mg