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PRODUCT NAMECATALOG #DESCRIPTIONCITATIONSRANKING
1-O-Hexadecyl-2-O-acetyl-sn-glycerolsc-2005161-O-Hexadecyl-2-O-acetyl-sn-glycerol is an inhibitor of PKC. CAS # 77133-35-8

1-O-Hexadecyl-2-O-methyl-rac-glycerolsc-2019981-O-Hexadecyl-2-O-methyl-rac-glycerol is an inhibitor of PKC. CAS # 111188-59-1

(+/-)-1-Oleoyl-2-acetylglycerolsc-287175A potent and cell membrane permeable activator of protein kinase C. CAS # 86390-77-4

1-Stearoyl-2-arachidonoyl-sn-glycerolsc-202864DAG derivative. Endogenous activator of PKC. Produced via receptor-mediated inositol phospholipid hydrolysis CAS # 65914-84-3

(±) 1,2-Didecanoylglycerol (10:0)sc-287217Shown to promote protein kinase C in platelets. CAS # 82950-64-9

1,2-Dioctanoyl-sn-glycerolsc-202397Cell-permeable PKC activator. Shown to mimic the effects of tumor-promoting phorbol diesters on mitogenesis and EGF binding and action in intact cells. CAS # 60514-48-9

4α-Phorbolsc-203781Inactive compound that can be used as a negative control for other phorbol esters. CAS # 26241-63-4

(2S,5S)-8-Decylbenzolactam Vsc-220846Activator of protein kinase C with an improved selectivity for the α, β and γ isoforms.

6-(N-Decylamino)-4-Hydroxymethylindolesc-291161Displays activation properties of protein kinase c (PKC). CAS # 123597-55-7

7-Oxostaurosporinesc-2020277-Oxostaurosporine is the oxidized and highly fluorescent analogue of Antibiotics UCN-01 and UCN-02. 7-Oxostaurosporine is a inhibitor of protein kinase C and formation of cellular blebs induced by phorbols. CAS # 141196-69-2

α-Amyloid Precursor Protein Modulatorsc-204424A cell-permeable benzolactam derived PKC activator (Ki = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblast AG06848. Displays a marked loss of tumor promoting activity. CAS # 497259-23-1

(±)-α-CMBHCsc-222431The longer side-chain precursor of α-CEHC and a minor metabolite of α-tocopherol. Pretreatment of Hep-G2 cells with rifampicin, an inducer of the CYP3A family of cytochrome P450s, results in a 5-fold increase in α-CEHC. This shows that metabolism of α-tocopherol proceeds by initial ω-oxidation to precursors of α-CMBHC followed by β-oxidation to shorter chain metabolites such as α-CEHC. CAS # 7083-09-2

Cholesterol 3-sulfate sodium saltsc-202538Activates multiple protein kinase C (PKC) iso-enzymes, especially the ε, η and ζ isoforms. CAS # 2864-50-8

Dequalinium Chloridesc-203026An antitumor agent and PKC inhibitor. Potent and selective blocker of the apamin-sensitive small conductance Ca2+-activated K+ channel CAS # 522-51-0

Hispidinsc-203998Cell permeable inhibitor of PKCß. Exhibits stronger cytotoxic effect on cancer cells than on normal cells in vitro. CAS # 555-55-5

(+)-Indolactam Vsc-203085Used as negative control compound in studies with (-)-indolactam V (sc-202182). May contain traces of (-)-Indolactam V. CAS # 90365-56-3

Ingenol 3,20-dibenzoatesc-202663Activates PKC. Induces apoptosis. Anticancer agent. Has potent antileukemic activity in the P388 mouse assay. Shows unusually high mouse ear inflammatory activity. CAS # 59086-90-7

MDL-27,032sc-205953Potent vasodilator. Also Inhibts cAMP-dependent protein kinase (PKA) and protein kinase C. Inhibition is competitive with ATP and not competitive with phospholipid, diacylglycerol, phorbol ester and calcium.

Myelin basic protein (4-14), N-acetylatedsc-201155A specific substrate for α, β, γ isoforms of PKC, and a poor substrate for PKA, CaMKII, CKI, CKII, and phosphorylase kinase. CAS # 126768-94-3 (non-acetylated)

N-Myristoyl-Lys-Arg-Thr-Leu-Arg-OHsc-222009Efficient inhibitor of protein kinase C (PKC)-catalyzed histone phosphorylation. CAS # 125678-68-4

Tamoxifensc-208414Tamoxifen is a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. CAS # 10540-29-1

NGIC-Isc-222073A cell permeable, selective indolocarbazole, which functions as an inhibitor of protein kinase C.

NPC-15437 dihydrochloridesc-202742Selective inhibitor of protein kinase C (PKC). CAS # 136449-85-9

PKCβ Inhibitorsc-204199A potent and ATP-competitive inhibitor of PKCβ isozymes that shows selectivity over PKCα isoforms. CAS # 257879-35-9

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rac-2-Ethoxy-3-octadecanamido-1-propylphosphocholinesc-215787A protein kinase C inhibitor. CAS # 163702-18-9

rac-2-Methoxy-3-hexadecanamido-1-propylphosphocholinesc-215788An inhibitor of Protein kinase C. CAS # 163751-35-7

Resiniferonol 9,13,14-ortho-phenylacetatesc-20231020-Deacylated derivative of resiniferatoxin and tinyatoxin. Not active as a capsaicin analog. Directly binds and activates PKC. Useful as starting material for synthesis of resiniferatoxin analogs. CAS # 57852-42-3

Safingolsc-204258A lyso-sphingolipid protein kinase C (PKC) inhibitor; inhibits human PKCa, the major overexpressed isoenzyme in MCF-7 DOXR cells CAS # 15639-50-6

Phloretinsc-3548Phloretin is a calcium channel protein inhibitor. CAS # 60-82-2

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TER14687sc-204336Blocks the association between protein kinase Cq-V1 and p59fyn in a yeast reporter assay. Prevents normal translocation of PKCq in T cells. Has no effect on other PKC isozymes in Jurkat or normal T cells. CAS # 16931-84-3

TMB-8 • HClsc-3522A PKC inhibitor and an intracellular Ca2+ antagonist that blocks the release of Ca2+from intracellular stores. Used to distinguish dependence on intracellular versus extracellular Ca2+. CAS # 53464-72-5

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Y-27632 dihydrochloridesc-281642Y-287632 is a selective Rho-kinase inhibitor, which suppresses cholinergic nerve-mediated contractions. Suppresses nerve-mediated contractile responses stimulated by acetylcholine and noradrenaline. CAS # 146986-50-7

(Z)-4-Hydroxytamoxifensc-35424-Hydroxytamoxifen is an active metabolite of tamoxifen, an anti-estrogen agent. Additionally reported to irreversibly inhibit purified protein kinase C (PKC) in vitro through oxidative inactivation of the catalytic domain. CAS # 68047-06-3

Phorbol 12, 13-Dihexanoatesc-203421Phorbol 12, 13-Dihexanoate is a potent and hydrophobic PKC activator; and a potent tumor promoter. CAS # 37558-17-1

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Phorbol-12,13-didecanoatesc-202286Phorbol-12,13-didecanoate is an activator of PKC. CAS # 24928-17-4

LY-333,531 Hydrochloridesc-364215Potent, selective inhibitor of Protein Kinase C isozymes, PKC beta I(IC50=4.7 nM) and PKC beta II (IC50=5.9 nM). CAS # 169939-93-9

R 59-022sc-203227R 59-022 inhibits diacylglycerol kinase or DGK, and potentiates the activity of protein kinase C by inhibiting diacylglycerol metabolism. CAS # 93076-89-2

Ro 31-8220sc-200619Ro 31-8220 is a cell-permeable PKC inhibitor, that is selective for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-&epsilon isoforms. Shown to induce apoptosis in a variety of cell lines, and inhibit glycogen synthase kinase 3. CAS # 138489-18-6

1
Tamoxifen Citratesc-203288Tamoxifen Citrate is a potent and selective inhibitor of protein kinase C (PKC). This compound is an estrogen receptor antagonist in breast tissue and a high affinity activator of the GPR30 receptor. CAS # 54965-24-1

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