| | Peptide Receptor Ligands
- (1R,1'S,3'R/1R,1'R,3'S)-L-054,264
Potent and selective somatostatin sst2 receptor agonist (Ki values are 4, 537, 2480, 3614 and 5017 nM for cloned human sst2, sst1, sst4, sst3 and sst5 receptors respectively).| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-203766 | 208706-12-1 | C33H41N5O2•xH2O | 1 mg/10 mg |
- 2-Furoyl-LIGRLO-amide trifluoroacetate salt
A potent, selective protease-activated receptor 2 (PAR2) agonist where PAR-2 activation is associated with increases in cAMP and intracellular Ca(2+).| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-213814 | 729589-58-6 (non-salt) | C36H63N11O8 ·xC2HF3O2 | 1 mg |
- A-71623
A robust and selective CCL28 (cholecystokinin 1; CCK1) receptor agonist. In comparison to other CCL28 agonists the compound does not have a tyrosine residue in which sulfation is necessary for strong CCL28 agonist activity in larger peptides.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-203487 | 130408-77-4 | C44H56N8O9 | 1 mg |
- AC 55541
Potent and selective protease-activated receptor 2 (PAR2) agonist (pEC50 = 6.7) that displays no activity at other PAR subtypes or at over 30 other receptors involved in inflammation and nociception. Stimulates cell proliferation, PI hydrolysis andCa2+ mobilization in vitro (pEC50 values are 6.7, 5.9 and 6.6 respectively) and exhibits pronociceptive activity in vivo.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-203799 | 916170-19-9 | C25H20BrN5O3 | 10 mg/50 mg |
- (±)-AC 7954 hydrochloride
Highly selective, non-peptide urotensin II (UT) receptor agonist that displays potent activity at human and rat UT receptors (pEC50 values are 6.5 and 6.7 respectively).| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-203491 | 477313-09-0 | C19H20ClNO2 ·HCl | 10 mg/50 mg |
- AG 045572
Selective gonadotropin-releasing hormone (GnRH) receptor antagonist (Ki values are 2.2, 3.8 and 6.0 nM for mouse, rat and human receptors respectively). Suppresses testosterone and luteinising hormone (LH) levels in vivo.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-203499 | 263847-55-8 | C30H37NO5 | 1 mg/10 mg |
- Antalarmin hydrochloride
A non-peptide CRF-RI receptor antagonist. Blocks ACTH release stimulated by CRH, and inflammation induced by carageenin in studies.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-203820 | 220953-69-5 | C24H34N4.HCl | 10 mg/50 mg |
- APC 366
Selective inhibitor of the mast cell tryptase (Ki= 7.1 μM).| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-203516 | 178925-65-0 | C22H28N6O4 | 5 mg |
- BIBO 3304 trifluoroacetate
High affinity NPY Y1 receptor antagonist (IC50 values are 0.38 and 0.72 nM at human and rat receptors respectively) that displays > 2600-fold selectivity over Y2, Y4 and Y5 receptors. Inhibits NPY- and fasting-induced feeding in vivo following central administration. Also antagonizes anxiolytic-like effects of NPY.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-203841 | 191868-14-1 | C29H35N7O3 ·2CF3CO2H | 10 mg/50 mg |
- BIBP 3226 trifluoroacetate
Mixed non-peptide neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist (Ki values are 1.1, 79, 108, > 1000, > 1000 and >1000 for rNPY Y1, hNPFF2, rNPFF, rNPY Y2, rNPY Y4 and rNPY Y5 respectively) Produces an anxiogenic-like effect in rats following i.c.v. administration.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-203842 | 159013-54-4 (non-salt) | C27H31N5O3 ·CF3CO2H | 1 mg/10 mg |
- BIIE 0246
A selective non-peptide antagonist which binds to the neuropeptide NPY Y2RY2 receptor in a competitive manner. In addition, BIIE 0246 suppresses another neuropeptide, [ahx5-24]NPY.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-203530 | 246146-55-4 | C49H57N11O6•xH2O | 1 mg/10 mg |
- BMS 182874 hydrochloride
| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-361123 | 153042-42-3 | C17H19N3O3S.HCl | 10 mg/50 mg |
- BMS 193885
Potent, competitive neuropeptide (NPY) Y1 antagonist (Ki = 3.3 nM, IC50 = 5.9 nM) that displays > 47, > 100, > 160, > 160 and > 160-fold selectivity over σ1, α1, Y2, Y4 and Y5 receptors respectively. Reduces food intake and body weight via central Y1 inhibition and is brain penetrant.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-203848 | 186185-03-5 | C33H42N4O6 ·C3H6O3 | 10 mg/50 mg |
- Boc-MLF
| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-361128 | N/A | C25H39N3O6S | 1 mg |
- BQ 788 sodium salt
Selective ETB antagonist| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-203534 | 156161-89-6 | C34H50N5O7•Na | 1 mg |
- BQ-610
A highly selective ETA receptor antagonist (IC50= 20 nM) which attenuates ET-induced reduction in cardiac output. It also inhibits ET-1- and ET-3-induced activation of adenylate cyclase (IC50= 28.2 nM). BQ-610 is 30-fold more potent than BQ-123, in porcine aortic smooth muscle membrane assay. | Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-221380 | 141595-53-1 | C36H44N6O6 | 500 µg |
- CGP 71683 hydrochloride hydrate
Selective and potent non-peptide NPY Y5 receptor antagonist. | Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-203881 | 192322-50-2 | C26H29N5O2S ·HCl ·1/4 ·H2O | 10 mg/50 mg |
- CI 988
A selective and effective antagonist of CCKBR (CCK2, CCK-B) receptors. Described to block the elevated levels of cytosolic Ca2+ induced by CCK-8.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-205244 | 130332-27-3 | C35H42N4O6 | 10 mg/50 mg |
- CP 96345
| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-361160 | 132746-60-2 | C28H32N2O | 10 mg/50 mg |
- CP 99994 dihydrochloride
| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-361161 | 136982-36-0 | C19H24N2O.2HCl | 10 mg/50 mg |
- CP 154526
A compound described to act as a selective and potent non-peptide CRF-RI and ACTH antagonist.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-205268 | 157286-86-7 | C23H32N4 ·HCl | 10 mg/50 mg |
- CP 376395 hydrochloride
CRF1 receptor antagonist which is potent and selective. CRF-induced activation of the HPA axis is weakened in in vivo studies following oral activation.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-205271 | 175140-00-8 | C21H30N2 ·HCl | 10 mg/50 mg |
- Cyclosomatostatin
Non-selective somatostatin (sst) receptor antagonist. Effects of sst are blocked on release of growth hormone, insulin and glucagon, airway β-adrenergic function, modulation of ACh release and CRF-induced suppression of gastric empyting. Potentially acts as an sst receptor agonist in SH-SY5Y, the human neuroblastoma cell line.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-205280 | 84211-54-1 | C44H57N7O6 | 1 mg |
- [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P
| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-361166 | 96736-12-8 | C79H109N19O12 | 1 mg |
- Devazepide
A non-peptide CCL28 (cholecystokinin 1; CCK1) receptor antagonist. Shown to induce apoptosis and inhibit cell proliferation.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-203562 | 103420-77-5 | C25H20N4O2 | 10 mg/50 mg |
- EMD 66684
Potent, selective non-peptide AT1 receptor antagonist.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-203941 | 187683-79-0 | C28H30N8O2 ·HCl | 10 mg/50 mg |
- FK 888
| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-361178 | 138449-07-7 | C36H36N4O4 | 10 mg |
- FPR A14
Formyl peptide receptor (FPR) agonist that potently activates neutrophils in vitro (EC50 values are 42 and 630 nM for neutrophil chemotaxis and Ca2+ mobilization respectively). | Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-294992 | N/A | C23H20N2O5 | 10 mg/50 mg |
- GR 159897
A compound that acts as an effective and selective NK2 receptor antagonist.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-361193 | 158848-32-9 | C23H27FN2O2S | 10 mg/50 mg |
- GR 231118
| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-361194 | 158859-98-4 | C110H170N34O24 | 500 µg |
- GW 803430
| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-363281 | 515141-51-2 | C25H24ClN3O3S | 10 mg/50 mg |
- ICI 216,140
| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-361211 | 124001-41-8 | C45H65N13O8 | 1 mg |
- IRL-2500
Potent, selective ET(B) antagonist.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-204018 | 169545-27-1 | C36H35N3O4 | 10 mg |
- JNJ 5207787
| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-361218 | 683746-68-1 | C32H38N4O2 | 10 mg/50 mg |
- L 760735
| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-362760 | 171242-11-8 | C26H28F7N5O2.HCl | 10 mg/50 mg |
- L-152,804
Potent, selective non-peptide neuropeptide Y Y5 receptor antagonist (Ki = 26 nM for hY5). Displays > 300-fold selectivity over hY1, hY2, and hY4 receptors. Causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Centrally active upon oral administration in vivo.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-203618 | 6508-43-6 | C23H26O4 | 10 mg/50 mg |
- L-168,049
Potent, orally active non-peptidyl human glucagon receptor antagonist.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-204034 | 191034-25-0 | C24H20BrClN2O | 10 mg/50 mg |
- L-368,899 hydrochloride
Potent, non-peptide spiroindenylpiperidine camphor-sulfonamide oxytocin receptor antagonist.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-204037 | 148927-60-0 | C26H42N4O5S2•HCl | 1 mg/10 mg |
- L-371,257
Orally active potent and selective oxytocin (OT) receptor antagonist.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-204038 | 162042-44-6 | C28H33N3O6 | 10 mg |
- L-692,585
Potent, non-peptidyl growth hormone (GH) secretagogue. Will increase growth hormone levels in vivo.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-204043 | 145455-35-2 | C32H37N7O3•xH2O | 10 mg |
- L-732,138
A selective nonpepetide tachykinin NK-1R antagonist with 1000 fold more potency towards the NK-1R receptor over NK-2R and NK-3R receptors with an IC50 = 2.3 nM.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-203437 | 148451-96-1 | C22H18F6N2O3 | 10 mg/50 mg |
- L-733,060 hydrochloride
| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-361226 | 148700-85-0 | C20H19F6NO.HCl | 10 mg/50 mg |
- L-803,087 trifluoroacetate
Potent and selective sst4 agonist
Potent and selective somatostatin sst4 receptor agonist. Ki values are 0.7, 199, 4720, 1280 and 3880 nM for cloned human sst4, sst1, sst2, sst3 and sst5 receptors respectively. Facilitates AMPA-mediated hippocampal synaptic responses in vitro and increases kainate-induced seizures in mice in vivo.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-203619 | 217480-26-7 | C25H29F2N5O3 ·CF3CO2H | 10 mg |
- LRGILS-NH2
| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-361979 | 245329-01-5 | C29H56N10O7 | 1 mg |
- L-817,818
Potent and selective non-peptide somatostatin subtype-5 receptor agonist. Inhibits growth hormone release from rat pituitary cells and insulin release from mouse pancreatic islets in vitro.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-204048 | 217480-27-8 | C33H36N4O3 | 10 mg |
- LU AA33810
A potent neuropeptide Y (NPY) Y5 receptor antagonist. Displays ≥ 3300-fold affinity for Y5 over Y1, Y2 and Y4 receptors. Also binds human 5-HT2B and 5-HT1A receptors (Ki values are 247 and 478 nM respectively). Exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-295367 | 304008-29-5 | C19H25N3O2S3 | 10 mg/50 mg |
- LY 225910
| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-361237 | 133040-77-4 | C27H24BrN3O2 | 5 mg/25 mg |
- LY 288513
| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-361242 | 147523-65-7 | C22H18BrN3O2 | 10 mg/50 mg |
- NBI 27914 hydrochloride
A selective corticotropin-releasing factor 1 inhibitor.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-204119 | 184241-44-9 | C18H20Cl4N4•HCl | 10 mg/50 mg |
- NBI-31772
A non-peptide ligand. Exhibits high-affinity towards all six human insulin-like growth factor-I binding proteins (IGFBPs). Displaces insulin-like growth factor-I (IGF-I) from the IGF-I:IGFBP complex in 3T3 fibroblasts, but does not interact with the IGF receptors.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-222047 | N/A | C17H11NO7 | 5 mg |
- NNC 26-9100
| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-361276 | 199522-35-5 | C22H25N6Cl2SBr | 10 mg |
- NTNCB hydrochloride
Potent, selective, competitive non-peptidic Y5 antagonist. Ki values are 8.0 and 16032 nM at human recombinant Y5 and Y1 receptors respectively. Potently antagonizes NPY inhibition of forskolin-stimulated cAMP. Some affinity for cloned human D2 and α2C receptors (Ki values are 63 and 100 nM respectively).| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-203655 | 486453-65-0 | C25H33N3O4S.HCl | 10 mg/50 mg |
- Oxytocin acetate salt hydrate
Involved in uterine contraction and lactation.
Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 [Disulfide Bridge: 1-6]| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-279938 | 50-56-6 | C43H66N12O12S2 | 1 mg/5 mg |
- PD 135158
A specific and effective CCK-BR antagonist. Reported to show limited affinity for substance P, benzodiazepine, GABAA, neurotensin, bradykinin, and 5-HT3 binding sites.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-204163 | 130325-35-8 | C35H44N4O6•1/2H20 | 10 mg/50 mg |
- PD 160170
Potent, selective non-peptide NPY Y1 antagonist; ; selective over Y2 and Y5 receptors. Antagonizes NPY-mediated inhibition of cAMP accumulation in SK-N-MC cells.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-204836 | 181468-88-2 | C18H17N3O4S | 10 mg/50 mg |
- PD 168368
Neuromedin B antagonist displaying ~40-fold selectivity over GRP-R, BB2 and >300-fold selectivity over BRS-R. Antagonizes neuromedin B-stimulated Ca2+ release and inhibits proliferation of rat glioma cells.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-204166 | 204066-82-0 | C31H34N6O4 | 1 mg/10 mg |
- PD 176252
Gastrin-releasing peptide and Neuromedin B antagonist. Inhibits proliferation of C6 glioma cells as well as NCI-H1299 xenograft proliferation in nude mice.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-204171 | 204067-01-6 | C32H36N6O5 | 10 mg |
- [PYR1]-APELIN-13
The pyro-glutamine form of Apelin-13 (sc-351718) that has shown high activity.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-359030 | 217082-60-5 | C69H108N22O16S | 1 mg |
- RO 90-7501
Inhibitor of amyloid β42 (Aβ42) fibril assembly; reduces Aβ42-induced toxicity (EC50 = 2 μM).| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-204891 | 293762-45-5 | C20H16N6 | 10 mg/50 mg |
- RP 67580
Potent and selective tachykinin NK1 receptor antagonist. Displays higher affinity at rat and mouse than human receptors. Antinociceptive in vivo, possibly partly via inhibition of calcium channels. | Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-204894 | 135911-02-3 | C29H30N2O2•xH2O | 10 mg/50 mg |
- S 25585
| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-361325 | 263-849-50-9 | C22H23F3N4O6S | 10 mg/50 mg |
- SB 218795
Potent, selective non-peptide NK3 antagonist| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-224280 | 174635-53-1 | C25H20N2O3 | 10 mg/50 mg |
- SB 222200
Potent, selective non-peptide NK3 antagonist. Brain penetrant| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-224282 | 174635-69-9 | C26H24N2O | 10 mg/50 mg |
- SB 268262
| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-362793 | 217438-17-0 | C18H15N3O4S2 | 10 mg/50 mg |
- SB 334867
| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-361344 | 249889-64-3 | C17H13N5O2 | 1 mg/10 mg |
- SB 408124
| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-361345 | 288150-92-5 | C19H18F2N4O | 10 mg |
- SB-366791
A new, potent and selective vanilloid receptor (TRPV1) antagonist. An effective antagonist of hTRPV1 when stimulated by capsaicin, acid, or noxious heat.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-222293 | N/A | C16H14NO2Cl | 5 mg/25 mg |
- SCH 79797
A selective PAR1 antagonist that has been shown to inhibit binding of a high-affinity thrombin receptor-activating peptide.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-203693 | 245520-69-8 | C23H25N5 ·2HCl | 10 mg/50 mg |
- SDZ NKT 343
Highly selective human tachykinin NK1 antagonist receptor(IC50 values are 0.62 and 451 nM for human and rat receptors respectively) that displays > 130-fold selectivity over human NK2 and NK3 receptors. Potently antagonizes SP-induced Ca2+ efflux in vitro and inhibits mechanical hyperalgesia in vivo.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-204274 | 180046-99-5 | C33H33N5O5 | 10 mg |
- SLIGRL-NH2
| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-359903 | 171436-38-7 | C29H56N10O7 | 1 mg |
- SN 003
| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-361361 | 197801-88-0 | C19H25N5O2 | 10 mg |
- SR 142948
Highly potent non-peptide neurotensin (NT) receptor antagonist that binds with high affinity (IC50 = 0.32 - 3.96 nM). Attenuates amphetamine-induced hyperactivity and is orally active in vivo.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-204297 | 184162-64-9 | C39H51N5O6 | 1 mg/10 mg |
- SR 27897
An effective non-peptide antagonist of CCL28 (cholecystokinin 1; CCK1) receptors. Described to act as selective and robust ligand for CCL28 binding sites.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-204298 | 136381-85-6 | C20H14ClN3O3S | 10 mg/50 mg |
- SR 49059
Potent, selective, non-peptide, orally active vasopressin V1a receptor antagonist; devoid of agonist activity. Shows high affinity and efficacy at both rat (Ki = 1.6 nM) and human (Ki = 1.1-6.3 nM) V1a receptors. Potently antagonizes arginine vasopressin-induced effects in vitro (IC50 = 3.7 nM for inhibition of human platelet aggregation) and is orally active in vivo.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-204300 | 150375-75-0 | C28H27Cl2N3O7S | 10 mg |
- SSR 146977 hydrochloride
| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-361366 | 264618-44-2 | C35H42Cl2N4O2.HCl | 10 mg/50 mg |
- Sulfisoxazole
Selective ETA endothelin antagonist receptor (IC50 values are 600 and 2200 nM for ETA and ETB receptors respectively).| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-204313 | 127-69-5 | C11H13N3O3S | 50 mg |
- SUN-B 8155
In CHO/hCTR cells, non-peptide calcitonin (CT) receptor agonist fully stimulates cAMP production. Following i.p. administration, it also causes a significant reduction in serum calcium concentrations in vivo.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-203704 | 345893-91-6 | C14H15N3O3 | 10 mg/50 mg |
- T 98475
Potent, non-peptide, and orally active gonadotropin-releasing hormone (GnRH, LHRH) receptor antagonist (IC50 values are 0.2, 4.0 and 60 nM for human, monkey, and rat GnRH receptors respectively). Inhibits LH release in vitro (IC50 = 100 nM) and reduces plasma LH concentration in castrated male cynomolgus monkeys.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-204318 | 192887-28-8 | C37H37F2N3O4S | 1 mg |
- Taltirelin
Synthetic thyrotropin-releasing hormone (TRH) analog. Displays ~ 30-100-fold more potent CNS activity and ~ 50-fold weaker endocrine activity than TRH. Both antinociceptive and neuroprotective.
| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-204319 | 103300-74-9 | C17H23N7O5 | 1 mg/10 mg |
- TCS 1102
| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-361375 | 916141-36-1 | C27H26N4O2S | 10 mg/50 mg |
- TCS OX2 29
Potent orexin 2 receptor (OX2) antagonist (IC50 = 40 nM) that displays > 250 fold selectivity over OX1 and over 50 other ion channels, receptors and transporters.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-204329 | 372523-75-6 | C23H31N3O3•HCl•xH2O | 10 mg/50 mg |
- THIQ
Selective and potent melanocortin 4 (MC4) receptor agonist (IC50 values are 1.2, 761 and 2067 nM for human MC4, MC3 and MC1 receptors respectively). Following systemic administration, enhances intracavernosal pressure and stimulates erectile activity in rats ex copula.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-204343 | 312637-48-2 | C33H41ClN6O2 | 1 mg |
- TNF-α Antagonist
Also designated WP9QY, an cyclic peptide which mimics the most critical recognition loop on TNF receptor I.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-358755 | 199999-60-5 | C58H71N11O15S2 | 1 mg |
- Tramiprosate
Sulfated glycosaminoglycan (sGAG) mimetic that targets soluble amyloid β (Aβ) and maintains Aβ in a non-fibrillar form. Decreases brain amyloid plaque load by 30%, increases tau polymerization and is brain penetrant. Decreases Aβ42-induced neuronal death and inhibits amyloid deposition in vitro. Also a GABA analog that protects against the convulsant and cytotoxic activity of kainic acid in vivo.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-204353 | 3687-18-1 | C3H9NO3S | 50 mg |
- Wang resin
Useful resin in the synthesis of peptide acids using Fmoc synthesis strategy. Cleavage can be affected by 95% TFA.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-286858 | 201058-08-4 | N/A | 5 g/25 g |
- WIN 64338 hydrochloride
The first potent, non-peptide, competitive bradykinin B2 receptor antagonist. In organ bath studies, WIN 64338 inhibits [3H]-bradykinin binding on guinea pig trachea with nanomolar affinity but not active in the rabbit aorta (the classical bradykinin B1 preparation).| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-204398 | 151039-63-3 | C45H68ClN4OP.HCl | 10 mg/50 mg |
- YIL 781
| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-361410 | 875258-85-8 | C24H28FN3O2.HCl | 10 mg/50 mg |
- YM 022
Highly potent and selective non-peptide CCK2 silent antagonist (Ki values are 68 pM and 63 nM at CCK2 and CCK1 receptors respectively). Acts in vivo to potently inhibit gastrin-induced gastric acid secretion and histidine decarboxylase activation with a long duration of action.| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-204409 | 145084-28-2 | C32H28N4O3 | 10 mg/50 mg |
- ZD 7155 hydrochloride
| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-361418 | 146709-78-6 | C26H26N6O.HCl | 10 mg/50 mg |
|