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Peptide Receptor Ligands

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PRODUCT NAMECATALOG #DESCRIPTIONCITATIONSRANKING
(1R,1'S,3'R/1R,1'R,3'S)-L-054,264sc-203766A potent and selective somatostatin sst2 receptor agonist CAS # 208706-12-1

2-Furoyl-LIGRLO-amide trifluoroacetate saltsc-213814A potent, selective protease-activated receptor 2 (PAR2) agonist where PAR-2 activation is associated with increases in cAMP and intracellular Ca(2+). CAS # 729589-58-6 (non-salt)

AC 264613sc-358026AC 264613 is a selective and potent protease-activated receptor 2 (PAR2) agonist. CAS # 1051487-82-1

AC 55541sc-203799Potent and selective protease-activated receptor 2 (PAR2) agonist (pEC50 = 6.7) that displays no activity at other PAR subtypes or at over 30 other receptors involved in inflammation and nociception. Stimulates cell proliferation, PI hydrolysis andCa2+ mobilization in vitro (pEC50 values are 6.7, 5.9 and 6.6 respectively) and exhibits pronociceptive activity in vivo. CAS # 916170-19-9

NPY 5RA972sc-295945NPY 5RA972 is a potent and selective NPY5-R (neuropeptide Y) antagonist (IC50 values are 3.1, >10000, >10000 and >10000 nM for NPY5-R, NPY1-R, NPY2-R and NPY4-R respectively). T CAS # 439861-56-0

Antalarmin hydrochloridesc-203820Antalarmin hydrochloride is a non-peptide CRF-RI receptor antagonist. The compound blocks ACTH release stimulated by CRH, and inflammation induced by carageenin in studies. CAS # 220953-69-5

APC 366sc-203516Selective inhibitor of the mast cell tryptase (Ki= 7.1 μM). CAS # 178925-65-0

BIBO 3304 trifluoroacetatesc-203841BIBO 3304 trifluoroacetate is a high affinity NPY1-R antagonist. BIBO 3304 trifluoroacetate also antagonizes anxiolytic-like effects of NPY (neuropeptide Y). CAS # 191868-14-1

BIBP 3226 trifluoroacetatesc-203842BIBP 3226 trifluoroacetate is a mixed non-peptide neuropeptide Y Y1 receptor (NPY1-R) and NPFF (neuropeptide FF) receptor inhibitor. CAS # 159013-54-4 (non-salt)

BMS 193885sc-203848BMS 193885 is a potent, competitive NPY1-R antagonist and reduces food intake and body weight via central NPY1-R inhibition and is brain a penetrant. CAS # 186185-03-5

CI 988sc-205244CI-988 is a selective and effective antagonist of CCK-BR (CCK2, CCK-B) receptors. It is described to block the elevated levels of cytosolic Ca2+ induced by CCK-8. CAS # 130332-27-3

CP 96345sc-361160CP 96345 is a selective and potent non-peptide NK1receptor antagonist. CAS # 132746-60-2

CP 154526sc-205268CP 154526 is a compound described to act as a selective and potent non-peptide CRF-RI and ACTH antagonist. CAS # 157286-86-7

CP 376395 hydrochloridesc-205271CP 376395 hydrochloride is a CRF-RI receptor antagonist which is potent and selective. CAS # 175140-00-8

Dihydrosphingosine-1-phosphate, D-erythrosc-223941Dihydrosphingosine-1-phosphate, D-erythro is a saturated analog of sphingosine-1-phosphate. CAS # 28508-07-8

Cyclosomatostatinsc-205280Cyclosomatostatin is a non-selective somatostatin (SST) receptor antagonist. CAS # 84211-54-1

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance Psc-361166[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P has been shown to be a broad spectrum neuropeptide antagonist and inverse agonist. This compound has also been reported to be a potent full inverse agonist for the ghrelin receptor (GHS-R1). CAS # 96736-12-8

(Glp1)-Apelin-13sc-359030(Glp1)-Apelin-13 is a highly potent proglutamyl form of apelin-13. (Glp1)-Apelin-13 is an endogenous ligand for apelin (APJ) receptor. CAS # 217082-60-5

GW 803430sc-363281GW 803430 is a selective melanin-concentrating hormone receptor 1 (MCH1) antagonist (IC50 = 9.3 nM). CAS # 515141-51-2

L 760735sc-362760L 760735 is a high-affinity NK1 reeptor antagonist (IC50 = 0.19 nM at human NK1 receptors. This compound is selective over NK2 and NK3 receptors. CAS # 171242-11-8

LRGILS-NH2sc-361979Reversed amino acid sequence control peptide for SLIGRL-NH2 (sc-359903), a protease-activated receptor-2 (PAR2) agonist that facilitates gastrointestinal transit in vivo. CAS # 245329-01-5

LU AA33810sc-295367LU AA33810 is a potent NPY5-R antagonist, displays ≥ 3300-fold affinity for NPY5-R over NPY1-R, NPY2-R and NPY4-R. LU AA33810 also binds human 5-HT2B and 5-HT1A receptors. CAS # 304008-29-5

LY 288513sc-361242LY 288513 is aselective CCK-BR antagonist . CAS # 147523-65-7

PD 135158sc-204163PD 135158 is a specific and effective CCK-BR antagonist. It has been reported to show limited affinity for substance P, benzodiazepine, GABAA, neurotensin, bradykinin, and 5-HT3 binding sites. CAS # 130325-35-8

PD 168368sc-204166Neuromedin B antagonist displaying ~40-fold selectivity over GRP-R, BB2 and >300-fold selectivity over BRS-R. Antagonizes neuromedin B-stimulated Ca2+ release and inhibits proliferation of rat glioma cells. CAS # 204066-82-0

PD 176252sc-204171PD 176252 is a GRPR inhibitor (non-peptide gastrin-releasing peptide receptor, BB2) and NMBR inhibitor (neuromedin B receptor, BB1) (Ki values are 1.0 and 0.17 nM for GRPR and NMBR respectively). CAS # 204067-01-6

RO 90-7501sc-204891Inhibitor of amyloid β42 (Aβ42) fibril assembly; reduces Aβ42-induced toxicity (EC50 = 2 μM). CAS # 293762-45-5

RP 67580sc-204894RP 67580 is a potent and selective tachykinin NK1 receptor antagonist. Displays higher affinity at rat and mouse than human receptors. CAS # 135911-02-3

SB 218795sc-224280SB 218795 is a potent, selective non-peptide NK3 antagonist. CAS # 174635-53-1

SB 222200sc-224282SB 222200 is a potent, selective non-peptide NK3 antagonist. CAS # 174635-69-9

SB 268262sc-362793SB 268262 is a calcitonin inhibitor. CAS # 217438-17-0

SB 408124sc-361345SB 408124 is a selective non-peptide orexin R-1 receptor antagonist (Kb values are 21.7 and 1405 nM for human orexin R-1 and orexin R-2 receptors respectively). CAS # 288150-92-5

SCH 79797sc-203693SCH 79797 is a nonpeptide selective inhibitor of Thrombin R (PAR1), a thrombin-activated receptor. CAS # 245520-69-8

SDZ NKT 343sc-204274SDZ NKT 343 is a highly selective human tachykinin NK1 antagonist receptor(IC50 values are 0.62 and 451 nM for human and rat receptors respectively) that displays > 130-fold selectivity over human NK2 and NK3 receptors. SDZ NKT 343 potently antagonizes SP-induced Ca2+ efflux in vitro. CAS # 180046-99-5

SLIGRL-NH2sc-359903SLIGRL-NH2 is a PAR2-activating peptide. CAS # 171436-38-7

SR 27897sc-204298SR 27897 is an effective non-peptide antagonist of CCK(cholecystokinin) receptors. CAS # 136381-85-6

SSR 146977 hydrochloridesc-361366SSR 146977 hydrochloride has been shown to be a selective and potent NK3 receptor antagonist. CAS # 264618-44-2

Sulfisoxazolesc-204313Sulfisoxazole is a selective ETAR antagonist. CAS # 127-69-5

SUN-B 8155sc-203704In CHO/hCTR cells, non-peptide calcitonin (CT) receptor agonist fully stimulates cAMP production. Following i.p. administration, it also causes a significant reduction in serum calcium concentrations in vivo. CAS # 345893-91-6

T 98475sc-204318T 98475 is a potent, non-peptide gonadotropin-releasing hormone (GnRH, LHRH) receptor antagonist (IC50 values are 0.2, 4.0 and 60 nM for human, monkey, and rat GnRH receptors respectively). Inhibits LH release in vitro (IC50 = 100 nM). CAS # 192887-28-8

Taltirelinsc-204319Synthetic thyrotropin-releasing hormone (TRH) analog. Displays ~ 30-100-fold more potent CNS activity and ~ 50-fold weaker endocrine activity than TRH. Both antinociceptive and neuroprotective. CAS # 103300-74-9

TCS OX2 29sc-204329TCS OX2 29 is a potent orexin R-2 receptor (OX2) antagonist (IC50 = 40 nM) that displays > 250 fold selectivity over OX1 and over 50 other ion channels, receptors and transporters. CAS # 372523-75-6

THIQsc-204343THIQ is a selective and potent melanocortin 4 receptor (MC4-R) agonist (IC50 values are 1.2, 761 and 2067 nM for human MC4-R, MC3-R and MC1-R respectively). F CAS # 312637-48-2

TNF-α Antagonistsc-358755TNFα Antagonist is a cyclic peptide mimic of the most critical recognition loop on TNF receptor I and blocks interaction of TNF with its receptor. CAS # 199999-60-5

Tramiprosatesc-204353Sulfated glycosaminoglycan (sGAG) mimetic that targets soluble amyloid β (Aβ) and maintains Aβ in a non-fibrillar form. Decreases brain amyloid plaque load by 30%, increases tau polymerization and is brain penetrant. Decreases Aβ42-induced neuronal death and inhibits amyloid deposition in vitro. Also a GABA analog that protects against the convulsant and cytotoxic activity of kainic acid in vivo. CAS # 3687-18-1

WIN 64338 hydrochloridesc-204398WIN 64338 hydrochloride is a bradykinin B2 R Inhibitor. CAS # 151039-63-3

YIL 781sc-361410YIL 781 has been shown to be a ghrelin receptor (GHS-R1) antagonist that improves glucose tolerance. CAS # 875258-85-8

YM 022sc-204409YM 022 is a highly potent and selective non-peptide CCK-BR silent antagonist. CAS # 145084-28-2

ATC 0065sc-358785ATC 0065 is a selective and potent antagonist of the melanin-concentrating hormone receptor 1 (MCH1) with reported affinity for 5-HT1A and 5-HT2B receptors. CAS # 510732-84-0