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PAF-R Inhibitors

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For functional analysis of PAF-R Inhibitors, see our complete listing of PAF-R Antibodies.

CV-3988sc-201015CV-3988 is a specific antagonist of PAF binding to the PAF-R. It inhibits PAF-induced platelet aggregation. CAS # 85703-73-7

Ginkgolide B (BN 52021)sc-201037Ginkgolide B (BN 52021) is the most potent member of ginkgolide family of PAF-R antagonists. It has been found to accelerate PAF hydrolysis by promoting PAF-AH I α2 homodimer activity. CAS # 15291-77-7

PCA 4248sc-203446PCA 4248 is a dihydropyridine that inhibits PAF in a competitive manner at the PAF-R level. It has been shown to also reduce serotonin secretion caused by PAF. CAS # 123875-01-4

Octylonium Bromidesc-201035Octylonium Bromide has been reported to antagonize PAF induced aggregation of rabbit platelet-rich plasma. It demonstrates the ability to potently block neuronal nicotinic acetylcholine receptors. CAS # 26095-59-0

(±) trans-2,5-Bis(3,4,5-trimethoxyphenyl)-1,3-dioxolanesc-201029(±) trans-2,5-Bis(3,4,5-trimethoxyphenyl)-1,3-dioxolane is a selective and potent PAF-R antagonist of the diaryl tetrahydrofuran class. It has been reported to block LTP in field CA1 in rat hippocampus. CAS # 116673-45-1

WEB-2086sc-201007WEB-2086 (Apafant) is a PAF-R (Platelet Activating Factor receptor) antagonist shown to have anticancer and cell differentiation effects. CAS # 105219-56-5

Gossypolsc-200501Gossypol is a reversible inhibitor of PP2B (protein phosphatase 2B), mitotic kinesin Eg5, and PKC (protein kinase C). Gossypol also potentially inhibits PAF-R, Bcl-2, 5-LO (5-lipoxygenase), and 12-LO. CAS # 303-45-7

A-85783sc-214441A-85783 is a selective and potent platelet-activating factor receptor (PAF-R) antagonist that has shown to be effective in vitro and in vivo. CAS # 161395-33-1

ABT-491 hydrochloridesc-214459ABT-491 hydrochloride is a highly potent, selective and orally active platelet-activating factor receptor (PAF-R) antagonist. CAS # 189689-94-9

CV-6209sc-207461A competitive PAF receptor antagonist. Inhibits PAF induced human platelet aggregation and PAF induced hypotension and lethality. CAS # 100488-87-7