MDM2 Inhibitors

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For functional analysis of MDM2 Inhibitors, see our complete listing of MDM2 Antibodies.

PRODUCT NAME	CATALOG #	DESCRIPTION	CITATIONS
Caylin-1	sc-223878	Caylin-1 is a nutlin-3 analog that activates p53 and subsequently induces apoptosis by disrupting MDM2-p53 interaction.
Caylin-2	sc-223879	Caylin-2 disrupts the MDM2-p53 complex by inhibiting MDM2. This promotes apoptosis by increasing the concentration of free p53 in the cytoplasm.
NSC 66811	sc-311507	NSC 66811 is a potent MDM2 inhibitor (Ki = 120 nM) which disrupts MDM2-p53 interaction and activates p53 function, leading to apoptosis. CAS # 6964-62-1
p53 Activator III, RITA	sc-202753	p53 Activator III, RITA, also referred to as NSC 652287, is a trycyclic thiophene derivative that binds to MDM2 and activates p53, inducing apoptosis. CAS # 213261-59-7	3
Nutlin-3	sc-45061	Nutlin-3, the most commonly used form of nutlin exhibits potent antiproliferative activity in cells with functional p53, but not in cells with mutated p53 CAS # 548472-68-0	3
(−)-Nutlin-3	sc-222086	(−)-Nutlin-3 is a cis-imidazoline analog, which inhibits the interaction between the proteins p53 and Mdm2. CAS # 548472-68-0
MDM2 Inhibitor	sc-204072	MDM2 inhibitor is a cell-permeable compound that exhibits selective inhibition of MDM2 which disrupts the MDM2-p53 complex, resulting in apoptosis. CAS # 562823-84-1