Kinase Inhibitors

• 1-(5-Isoquinolinesulfonyl)-3-methylpiperazine, hydrochloride
  A selective inhibitor of protein kinase C or cyclic-nucleotide-dependent protein kinases.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-213276	141543-65-9	C14H17N3O2S•HCl	25 mg

• 1-(5-Isoquinolinesulfonyl)piperazine Hydrochloride
  Exhibits potent inhibition toward protein kinase C and cyclic nucleotide dependent protein kinases.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-213277	141543-63-7	C13H16ClN3O2S	25 mg

• 1-(5-Isoquinolinylsulfonyl)-3-methylpiperazine dihydrochloride
  A lesser potent inhibitor of phosphokinase C than H-7.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-213278	140663-38-3	C14H19Cl2N3O2S	5 mg/25 mg

• 1-Naphthyl PP1
  A kinase inhibitor that inhibits src family kinses v-Src, c-Fyn, and the proto-oncogene c-Abl.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203765	221243-82-9	C19H19N5	10 mg/50 mg

• 1,2,3,4-Tetrahydro Staurosporine
  Staurosporine derivative used as an isoenzyme PKCå inhibitor and as an anticancer agent.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-206233	220038-19-7	C28H30N4O3	500 µg

• 1,3-Bis-(o-tert-butyldimethylsilyl)-Fmoc-D-erythro-sphingosine
  Protected Sphingosine.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-213489	N/A	C45H75NO4Si2	25 mg

• 2-Aminopurine Dihydrochloride
  A purine analog that acts as a protein kinase inhibitor. It acts as a mutagen, can override checkpoints of the cell cycle and induce S-phase arrested cells to enter mitosis incorrectly.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-201524	76124-64-6	C5H5N5•2HCl	100 mg/500 mg

• 2-Azido-1-pivaloyl-D-erythro-Sphingosine
  A derivative of Sphingosine. A selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets. Also inhibits calmodulin-dependent enzymes.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-206402	114275-41-1	C23H43N3O3	20 mg

• 2-Bromoaldisine
  Inhibitor of the Raf/MEK-1/MAPK cascade (IC₅₀= 539nM).

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-202880	96562-96-8	C8H7BrN2O2	0.5 mg

• 2,3,6-Trideoxy-Ins(1,4,5)P3. 6Na
  Exhibits relatively low ligand binding affinity to the Ins(1,4,5)P3 receptor of bovine adrenal cortex membranes and acts as a weak agonist in releasing calcium from saponin permeablized SH-Sy5Y human neurolastoma cells.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-220787	N/A	N/A	1 mg

• (2S,3R,4E)-2-Azido-3-(tert-butyldimethylsilyl)-1-pivaloyl-erythro-sphingosine
  A derivative of Sphingosine. Selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets. Inhibits calmodulin-dependent enzymes.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-206567	114275-42-2	C29H57N3O3Si	20 mg

• (2S,3R,4E)-2-Azido-3-(tert-butyldimethylsilyl)-erythro-sphingosine
  A derivative of Sphingosine, a selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets. Also inhibits calmodulin-dependent enzymes.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-206568	114299-64-8	C24H49N3O2Si	10 mg

• 3-O-(tert-Butyldimethylsilyloxy)-2-Fmoc-erythro-sphingosine
  A derivative of Sphingosine that is a selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets. This compound does not inhibit protein kinase A or myosin light chain kinase, but does inhibit calmodulin-dependent enzymes.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-206670	149035-77-8	C39H61NO4Si	10 mg

• 3-O-(tert-Butyldimethylsilyloxy)-erythro-sphingosine
  This derivative of Sphingosine is a selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets. This compound does not inhibit protein kinase A or myosin light chain kinase, although it inhibits calmodulin-dependent enzymes.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-206671	137905-29-4	C24H51NO2Si	10 mg

• 3,4-Dihydro-2H,10H-azepino[3,4-b]indole-1,5-dione Methanesulfonate Salt
  A myt1 kinase inhibitor used in the treatment of proliferative diseases

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-206703	68724-84-5	C13H14N2O5S	5 mg

• 4-Amino-1-tert-butyl-3-(3-methylbenzyl)pyrazolo[3,4-d]pyrimidine
  A highly potent and uniquely specific tyrosine kinase inhibitor of v-Src tyrosine kinase.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-206805	956025-83-5	C17H21N5	10 mg

• 5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-[[4-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarboxamide
  A potent benzimidazole analog that inhibits IKK-ε with an IC₅₀ value of ~15.8 µM, where IKK-ε is mostly expressed n immune cells and thought to play a role in immune response.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-205128	916985-21-2	C22H21N3O6S2	1 mg/5 mg

• 5-Iodo-Indirubin-3'-monoxime
  A highly potent of glycogen synthase kinase-3β inhibitor. Also inhibits Cdk1 and Cdk5 activities. Acts by binding to the ATP-binding pocket of these enzymes.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-221754	N/A	C16H10IN3O2	1 mg

• 5'-Tosyl Thymidine
  A nucleoside analogue used as inhibitors of thymidylate kinases

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-207074	7253-19-2	C17H20N2O7S	250 mg

• 7-Azaoxindole
  Used for preparation of 3-(anilinomethylene) oxindoles and analogs as protein tyrosine kinase and protein serine/threonine kinase inhibitors.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-207155	5654-97-7	C7H6N2O	100 mg

• 7,8-Dihydro-9-[2-(4-bromophenyl)hydrazone]-5H-pyrido[3,2-b]azepine-6,9-dione
  A GSK-3 inhibitor used

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-207184	676596-64-8	C15H13BrN4O	10 mg

• A 419259 trihydrochloride

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-361094	364042-47-7	C29H34N6O•3HCl	10 mg

• A 83-01
  Selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC₅₀ values are 12, 45 and 7.5 nM respectively). Blocks phosphorylation of Smad2 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. Only weakly inhibits ALK-1, -2, -3, -6 and MAPK activity. More potent than SB 431542.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203791	909910-43-6	C25H19N5S	10 mg/50 mg

• AAL-993
  A highly potent inhibitor of VEGFR-1, VEGFR-2 and VEGFR-3 (IC₅₀=130nM, IC₅₀=23nM and IC₅₀=18nM respectively). At higher concentrations it inhibits PDGFR-β (640nM), c-Kit (236nM) and CSF-1R (380nM).

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-221195	269390-77-4	C20H16N3OF3	5 mg/25 mg

• Adenosine Kinase Inhibitor
  Cell-permeable. Acts as a potent, adenosine-competitive, and reversible adenosine kinase (AK) inhibitor.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-202900	214697-26-4	C22H19BrN6O•2HCl•xH2O	5 mg

• Adaphostin
  A p210bcr/abl tyrosine kinase inhibitor (IC50 = 14 μM). Induces apoptosis in T-lymphoblastic human leukemia cell lines (IC50 values range from 16.8 to 216.3 nM) in vitro. Has been shown to display selectivity for chronic myelogenous leukemia (CML) myeloid progenitors in vitro.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-291833	241127-58-2	C24H27NO4	10 mg/50 mg

• AEG 3482
  Cell-permeable imidazothiadiazole compound that activates HSF1 by binding to HSP90 and disrupting its association with HSF1.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-202911	63735-71-7	C10H8N4O2S2	5 mg

• (+)-Aeroplysinin-1
  Displays cytostatic and cytotoxic activity. Inhibitor of EGFR kinase. Shows antiangiogenic activity.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-202445	28656-91-9	C9H9Br2NO3	1 mg

• AG 43
  An inactive tyrphostin analogue that can be used a negative control parameter for other tyrphostins.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-202916	5553-97-9	C10H8N2O	5 mg

• AG 556
  Selectively inhibits EGF receptor kinase autophosphorylation (IC₅₀ = 5 µM) over HER1/2 autophosphorylation. Also blocks LPS-induced TNF-α production.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-202044	133550-41-1	C20H20N2O3	5 mg/25 mg

• AG-1296
  A potent inhibitor of PDGF receptor tyrosine kinase (IC₅₀=1 µM). Inhibits FGF receptor tyrosine kinase and c-kit.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-200631	146535-11-7	C16H14N2O2	5 mg/25 mg

• AG-490
  A tyrosine kinase inhibitor that belongs to the family of tyrphostins. Compound has been reported to inhibit JAK2 and not JAK1, Lck, Btk, Tyk2, Syk, Lyn, and Src.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-202046	134036-52-5	C17H14N2O3	10 mg/50 mg

• Akt Inhibitor
  A phosphatidylinositol ether analog that potently and selectively inhibits Akt (PKB) (IC₅₀ of 5.0 µM). Moderately inhibits PI 3-K activity (IC₅₀ = 83.0 µM). Also inhibits the growth of various cancer cell lines with IC₅₀ values in the 1 - 10 µM range.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-221226	N/A	C30H58O10	1 mg

• Akt Inhibitor III
  A phosphatidylinositol analog that inhibits the activation of Akt and select downstream substrates without decreasing phosphorylation of PDK-1 or other kinases downstream of Ras, such as MAPK.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-221228	N/A	C28H57O9P	1 mg

• Akt Inhibitor IV
  Inhibitor of Akt protein kinase and reported to inhibit the ATP-binding site of kinase upstream of AKT and downstream of PI3K.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203809	681281-88-9	C31H27IN4S	1 mg/5 mg

• Akt Inhibitor IX, API-59CJ-OMe
  A cell-permeable ellipticine compound that selectively and potently induces apoptosis in human endometrial cancer cells (RL95-2 and Ishikawa) that exhibit elevated Akt activity (effective concentration = 12-24 µM), but not on cells with low Akt activity.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203810	98510-80-6	C21H22N2O3 ·3H2O	5 mg

• Akt Inhibitor X
  A cell permeable, reversible, and selective inhibitory phenoxazine that suppresses the kinase reactivity of Akt by inhibiting its phosphorylation.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203811	925681-41-0	C20H25ClN2O ·HCl	5 mg

• Akt Inhibitor XI
  A cell-permeable copper complex that interacts with both the PH and the kinase domains of Akt and potently inhibits its kinase activity. Inhibits tumor growth both in cultured cells in vitro and in mice in vivo without any apparent adverse effect to the animals.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-221229	N/A	C11H9Cl2CuN3O2S	5 mg

• Akt Inhibitor XII, Isozyme-Selective, Akti-2
  A cell-permeable Akti-1/2- (sc-202048) derived allosteric inhibitor pair (1:1 regioisomeric mixture) with much improved aqueous solubility (10 mg/ml in a pH 7.4 saline) and Akt2 selectivity (IC₅₀ = 805 nM for Akt2, >10 µM for Akt1/3, and >50 µM for PKA/PKC/SGK). The inhibition is PH domain-dependent and non-competitive with ATP.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-221230	N/A	C39H39N7O2 ·3HCl	2 mg

• Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2
  A highly cell-permeable and water soluble analog of Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (sc-202048) that acts as a plecktrin homology (PH)-domain dependent, non-ATP competitive and an allosteric inhibitor of Akt1/2 (IC₅₀ = 560 nM, 390 nM and 7.8 µM in in vitro kinase assay; 526 nM, 730 nM and > 10 µM in LNCaP cells for Akt1, Akt2 and Akt3, respectively) with ~ 80-fold greater selectivity over PKA, PKC and SGK (IC5₅₀> 50 µM). One of its potent regioisomers (C7-substituted) is shown to enhance induced caspase-3 activity in several tumor cells.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-221231	N/A	C40H43N7O2 ·3HCl	2 mg

• AP 24534

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-362710	943319-70-8	C29H27F3N6O	10 mg/50 mg

• Apigenin
  Inhibits MAP kinase-associated signal transduction pathways and proliferation of malignant tumor cells by causing G₂/M arrest and induces morphological differentiation.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-3529	520-36-5	C15H10O5	5 mg/100 mg

• AS-604850
  This is a potent, cell permeable and ATP-competitive inhibitor of phosphoinositide 3-kinase γ (PI(3)Kγ). it exhibits selectivity over other PI(3)K isoforms.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-221271	648449-76-7	C11H5F2NO4S	1 mg/5 mg

• AS-605240
  This is a potent, cell permeable and ATP-competitive inhibitor of phosphoinositide 3-kinase γ (PI(3)Kγ). It exhibits selectivity over other PI(3)K isoforms.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-221272	648450-29-7	C12H7N3O2S	1 mg/5 mg

• ATM Kinase Inhibitor
  A cell-permeable, potent, selective and ATP-competitive inhibitor of ATM (Ataxia telangiectasia mutated). Shows inhibition specificity for other phosphatidylinositol 3'-kinase-like kinases.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-202963	587871-26-9	C21H17NO3S2	2 mg

• ATM/ATR Kinase Inhibitor

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-202964	905973-89-9	C23H18Cl3FN4O3S	5 mg

• Aurora Kinase Inhibitor II
  Aurora Kinase Inhibitor II is an anilinoquinazoline that is both a potent and selective ATP-competitive inhibitor of Aurora kinases and has the ability to permeate the cell.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203827	331770-21-9	C23H20N4O3	1 mg

• Aurora Kinase Inhibitor III
  A cell-permeable 2,4-dianilinopyrimidine compound that acts as an ATP-competitive, potent, but non-selective inhibitor of Aurora A (IC₅₀ = 42 nM). At higher concentrations, inhibits the activities of other kinases, such as Lck, Bmx, IGF-1R, and Syk as well(IC₅₀ = 131, 386, 591, and 887 nM, respectively).

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203828	879127-16-9	C21H18F3N5O	1 mg

• Avenanthramide-C methyl ester
  Avenanthramide-C methyl ester inhibits NF-κB activation by blocking the phosphorylation of IKK and IκB (IC₅₀ ~ 40 μM). Through this mechanism, avenanthramide-C methyl ester dose dependently inhibits the secretion and expression of IL-6, IL-8, and MCP-1 in human aortic endothelial cells.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-223786	955382-52-2	C17H15NO6	500 µg/1 mg

• AZ 3146

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-361114	1124329-14-1	C24H32N6O3	10 mg/50 mg

• Azido-erythro-sphingosine
  A derivative of Sphingosine. A selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets. Also inhibits calmodulin-dependent enzymes.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-207312	103348-49-8	C18H35N3O2	25 mg

• BAY R3401
  A glycogen phosphorylase inhibitor shown to suppress hepatic glycogenolysis.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-239281	100276-03-7	C20H22ClNO4	5 mg

• BC 11 hydrobromide

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-362712	443776-49-6	C8H11BN2O2S.HBr	10 mg/50 mg

• Bcr-abl Inhibitor II
  A cell-permeable thiadiazole compound that acts as an ATP binding site-targeting inhibitor of Abl and c-Src kinases (Ki = 44 and 354 nM, respectively). Effectively inhibits cellular Bcr-Abl Tyr245 phosphorylation and the clonogenic activity of Bcr-Abl-transformed 32D cells, regardless of their resistance to Imatinib/STI571.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-221289	N/A	C16H11F2N3OS2	5 mg

• BI 78D3
  Competitive c-Jun N-terminal kinase (JNK) inhibitor (IC₅₀ = 280 nM) that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K. Inhibits JNK interacting protein 1 (JIP1)-JNK binding (IC₅₀ = 500 nM) and prevents JNK substrate phosphorylation. Restores insulin sensitivity in a mouse model of type II diabetes and blocks JNK-dependent Con A-induced liver damage.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203840	883065-90-5	C13H9N5O5S2	10 mg/50 mg

• BIO-acetoxime

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-361122	667463-85-6	C18H12BrN3O3	1 mg/10 mg

• Bisindolylmaleimide V
  Negative control for the protein kinase C (PKC)-inhibitory activity.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-202080	113963-68-1	C21H15N3O2	1 mg/5 mg

• BML-257
  BML-257 is an potent inhibitor of AKT1 translocation and has been observed to attenuate cannabinoid agonist-simulated neurosphere proliferation.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-200666	32387-96-5	C21H14N2O2	10 mg/50 mg

• BML-275
  A cell-permeable pyrazolopyrimidine derivative that inhibits AMP Kinase in an ATP-competitive manner. Also inhibits morphogenetic protein signals.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-200689	866405-64-3	C24H25N5O	5 mg/25 mg

• βARK1 Inhibitor
  A selective inhibitor of βARK1 (β-Adrenergic Receptor Kinase 1). Has no inhibitory activity against protein kinase A (PKA).

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-221268	N/A	C12H9NO6	5 mg

• BRD 7389

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-361129	376382-11-5	C24H18N2O2	10 mg/50 mg

• BTO-1
  A cell-permeable benzothiazolo-N-oxide compound that targets the ATP-binding pocket of polo-like kinase and is shown to inhibit Plk1 kinase activity in cell-free kinase assays.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-204206	40647-02-7	C9H4N4O4S	2 mg

• CaMKP Inhibitor
  Amino-naphthol sulfonic acid that acts as a competitive substrate inhibitor of Ca²⁺/CaMKP and the nuclear isoform CaMKP-N. Exhibits little activity against PP2B/CaN and PP2C

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203866	52789-62-5	C10H8NNAO7S2 ·2H2O	100 mg

• Casein Kinase II Inhibitor III, TBCA
  A cell-permeable tetrabrominated cinnamic acid compound that acts as an ATP-competitive and potent inhibitor of Casein Kinase II with greater selectivity than DMAT and TBB (sc-202830).

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203869	934358-00-6	C9H4Br4O2	5 mg

• CAY10622

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-358882	1038549-25-5	C25H25N5O3	1 mg/5 mg

• CAY10576
  The NF-κB/Rel transcription factors, known to be involved in the pathogenesis of a variety of diseases and the regulation of pro-inflammatory cytokines, are present in the cytosol in an inactive state, complexed with inhibitory IκB proteins. NF-κB is activated upon degradation of IκB following IKK-α and IKK-β phosphorylation. IKK-ε, a homolog of IKKα and IKK-β, can also activate NF-κB. IKK-ε is expressed primarily in immune cells, and is thought to play a role in the immune response. CAY10576 is a benzimidazole analog that selectively inhibits IKK-ε with an IC₅₀ value of 40 nM and is essentially inactive at IKK-α and IKK-β.1

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-223870	862812-98-4	C22H19N3O5S2	1 mg/5 mg

• CCT 137690

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-362722	1095382-05-0	C26H31BrN8O	10 mg/50 mg

• Cell Sheet Migration Inhibitor, Locostatin
  A cell-permeable and potent inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203875	133812-16-5	C14H15NO3	10 mg

• Cell Sheet Migration Inhibitor, Negative Control
  A cell-permeable N-(butyryl)oxazolidinone compound which serves as a negative control for the Cell Sheet Migration Inhibitor. Displays little bioactivity during wound closure and cell proliferation studies.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-221412	N/A	C14H17NO3	5 mg

• Ceramide Kinase Inhibitor, K1
  A cell-permeable tetracyclic quinone compound that acts as a specific, reversible, and non-competitive inhibitor of CerK (ceramide kinase) activity with little effect against SPHK1/2 or DGK. Shown to reduce cellular C1P (ceramide-1-phosphate) synthesis by 40% at 20 µM in a rat basophilic leukemia cell line RBL-2H3 and block CerK-mediated degranulation in both RBL-2H3 and murine BMMC (bone marrow-derived mast cells) in a dose-dependent manner. Exhibits no cytotoxic effect against RBL-2H3 even at concentrations as high as 100 µM.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-221414	1258005-85-4	C21H28O4	1 mg

• CID 755673
  A selective and potent protein kinase D1-D3, PKC, CAK, PLK1 and CAMKIIα inhibitor. Reported to inhibit PKD-mediated protein transport and to reverse phorsphorylation of Ser-82 on small heat shock protein 27 (HSP27) in a human neuroblastoma cell line.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-205246	521937-07-5	C12H11NO3	10 mg

• Compound 401
  Cell-permeable pyrimido-isoquinolinone compound. Potent, reversible, and ATP-competitive inhibitor of DNA-PK with ~19-fold selectivity over mTOR.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-202552	168425-64-7	C16H15N3O2	5 mg

• Compound 56
  The most potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203430	171745-13-4	C18H18BrN3O2	500 µg

• Cucurbitacin I, Cucumis sativus L.
  Shown to be a Stat3 and JAK2 inhibitor. Also reported to contain in vitro anti-proliferative activity against certain cancer cells .

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203010	2222-07-3	C30H42O7	1 mg

• Cyclapolin 9
  Selective, ATP-competitive polo-like kinase 1 (PLK1) inhibitor.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-205279	40533-25-3	C9H4F3N3O4S	10 mg/50 mg

• DAG Kinase Inhibitor
  DAG Kinase Inhibitor is an inhibitor of DGK (Diacylglycerol kinase; DAG Kinase) and is useful for elucidating the roles of protein kinase C (PKC). This particular isoform, R59949, has been reported to potentially exhibit selective inhibition of DGK-α.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-3551	120166-69-0	C28H25F2N3OS	5 mg

• Debromohymenialdisine
  Inhibitor of G2 DNA damage checkpoint (IC₅₀=8µM),Chk1 (IC₅₀=3µM) and Chk2 (IC₅₀=3.5µM). DBH does not inhibit ATM or ATM-Rad3-related protein.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-202127	75593-17-8	C11H11N5O2	100 µg

• Dioctanoylglycol
  Diacylglycerol kinase inhibitor.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203567	627-86-1	C18H34O4	50 mg

• DMH-1

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-361171	1206711-16-1	C24H20N4O	10 mg/50 mg

• DMNB
  Cell-permeable vanillin derivative that acts as a potent and selective inhibitor of DNA-PK activity and DNA-PK-mediated DSB DNA repair by non-homologous DNA-end-joining (NHEJ).

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-202142	20357-25-9	C9H9NO5	10 mg

• DNA-PK Inhibitor II
  Shown to be a cell permeable potent antiproliferative agent. Reported to reduce lethal damage recovery in cells and DNA double strand break repair.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-202143	154447-35-5	C17H15NO3	10 mg/50 mg

• DNA-PK Inhibitor III
  Cell-permeable, potent, selective, and an ATP-competitive inhibitor of DNA-PK and PI 3-Kinase catalytic subunit p110∫.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203928	404009-40-1	C12H15NO3	1 mg

• DNA-PK Inhibitor IV
  A morpholino-salicylaldehyde compound which acts as a potent, selective and ATP-competitive inhibitor of DNA-PK. Inhibits PI 3-K catalytic subunit p110-isozymes at higher concentrations and weakly inhibits a panel of several other kinases.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-221562	N/A	C11H13NO3	1 mg

• DNA-PK Inhibitor V
  Potent, selective and ATP-competitive inhibitor of DNA-PK (IC50 = 270 nM); inhibits PI 3-K catalytic subunit p110-isozymes.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203929	404009-46-7	C17H17NO3	1 mg/5 mg

• Dorsomorphin dihydrochloride

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-361173	866405-64-3	C24H25N5O.2HCl	10 mg/50 mg

• DRB
  Shown to be an adenosine analogue which causes a premature termination of DNA transcription. Also reported to be a mixed-type inhibitor of casein kinase II.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-200581	53-85-0	C12H12Cl2N2O4	10 mg/50 mg

• eEF-2 Kinase Inhibitor, NH125
  Inhibits the activity of bacterial histidine kinases (EnvZ, PhoQ, BvgS, and EvgS) and eukaryotic eEF-2 kinase/CaMKIII.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203037	278603-08-0	C27H45IN2	5 mg

• ER 27319 maleate

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-361177	201010-95-9	C18H20N2O.C4H4O4	10 mg/50 mg

• FAK Inhibitor 14
  Selective FAK inhibitor that exhibits antiproliferative activity in a variety of human tumor cell lines in vivo, and promotes cell detachment/inhibits cell adhesion in vitro

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203950	4506-66-5	C6H2(NH2)4 ·4HCl	10 mg/50 mg

• FCCP
  Oxidative phosphorylation uncoupler in mitochondria.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203578	370-86-5	C10H5F3N4O	10 mg/50 mg

• FGF Receptor Tyrosine Kinase Inhibitor IV, NP603
  A cell-permeable SU6668 derivative that targets the ATP-binding pocket and inhibits the kinase activity of PDGFRβ, FGFR1 and VEGFR2, while showing little activity against EGFR. Exhibits anti-angiogenesis activity and suppress FGF-2-induced proliferation in HUVEC cultures in a dose-dependent manner.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-221613	N/A	C26H26N2O5	5 mg

• Flt-3 Inhibitor
  Cell-permeable thienylcarboxamide that acts as a potent, ATP-competitive, and highly selective Flt-3 inhibitor.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203048	301305-73-7	C18H20N2O4S	5 mg

• Flt-3 Inhibitor II
  A cell-permeable symmetrical indolylmethanone kinase inhibitor that is more selective to Flt3 over PDGFR; potently induces apoptosis in Flt3-expressing primary AML patient blasts.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203956	896138-40-2	C17H12N2O3	1 mg

• Flt3 Inhibitor IV
  A 3-aminoindazole compound that acts as a strong and ATP-competitive inhibitor of Flt3. It also exhibits excellent selectivity over KDR/VEGFR-2 and c-Kit.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-221615	N/A	C13H12N4	5 mg/25 mg

• FPA 124

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-361179	902779-59-3	C11H9Cl2CuN3O2S	10 mg/50 mg

• Genistin
  Isoflavone glycoside found in soy-based foods. An inactive analog of the PTK inhibitor Genistein. Can be used as a negative control for Genistein. Reportedly reduces bone loss in ovarectomized rats.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-202168	529-59-9	C21H20O10	5 mg

• Gold sodium thiomalate
  A gold(I) compound that inhibits the activity of IKK (ID₅₀ = 10.9 µM) and disrupts PB1 (Phox and Bem1p) domain-mediated interactions between Par6 and PKCi (IC₅₀ ~ 1 µM) by modifying cysteine residues within the catalytic domain of IKK and the PB1 domain of PKCi. Inhibits PKCi-dependent Rac1 activation in A549 cells.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203830	12244-57-4	C4H4AuNaO4S	50 mg

• GSK 1059615

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-361198	958852-01-2	C18H11N3O2S	10 mg/50 mg

• GSK 269962

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-363279	850664-21-0	C29H30N8O5	10 mg/50 mg

• GSK 429286

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-361200	864082-47-3	C21H16F4N4O2	1 mg/10 mg

• GSK 650394

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-361201	890842-28-1	C25H22N2O2	10 mg/50 mg

• GSK 690693

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-363280	937174-76-0	C21H27N7O3	10 mg/50 mg

• GTP 14564
  A cell-permeable tricyclic benzofurano-indazolo compound which functions as a specific inhibitor of class III receptor tyrosine kinases.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203062	34823-86-4	C15H10N2O	5 mg

• GW441756 hydrochloride
  A highly selective, potent TrkA kinase inhibitor which is orally active. IC₅₀ = 2 nM.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-215121	504433-24-3 (non-salt)	C17H13N3O•HCl	5 mg

• GW4869
  A cell permeable, selective inhibitor of N-SMase (neutral sphingomyelinase). This compound functions as an inhibitor, via a non-competitve manner.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-218578	6823-69-4	C30H28N6O2•2HCl	5 mg/25 mg

• H-1152 . dihydrochloride
  Cell permeable, highly specific, and potent ATP-competitive inhibitor of rho-kinase (ROCK) inhibitor.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203592	451462-58-1	C16H21N3O2S.2HCl	1 mg/5 mg

• H-1152 Dihydrochloride
  A ROCK Inhibitor. A cell-permeable isoquinolinesulfonamide compoud that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK).

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-207727	871543-07-6	C16H23Cl2N3O2S	2.5 mg

• I-OMe-Tyrphostin AG 538
  This product is an inhibitor of insulin growth factor 1 receptor protein tyrosine kinase.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-300821	N/A	C17H12INO5	5 mg

• IKK-2 Inhibitor XI

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-359906	N/A	C12H11N3O2S	5 mg

• IKK 16
  Selective IκB kinase (IKK) inhibitor (IC₅₀ values are 40, 70 and 200 nM for IKK-2, IKK complex and IKK-1 respectively). Inhibits TNF-α-stimulated IκB degradation and expression of adhesion molecules E-selectin, ICAM and VCAM (IC₅₀ values are 1.0, 0.5, 0.3 and 0.3 μM respectively). In vivo, inhibits LPS-induced TNF-α release and neutrophil extravasion in thioglycollate-induced peritonitis.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-204009	N/A	C28H29N5OS ·HCl	10 mg/50 mg

• IKK-2 Inhibitor VI
  An ureido-thiophenecarboxamide compound acting as a potent inhibitor of IKK-2.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-221743	N/A	C12H11N3O2S	1 mg

• IKK-3 Inhibitor IX
  A thiophenecarbonitrile compound that acts as a potent ATP-competitive inhibitor of IKK-3. Have shown to be inactive against cytochrome P450 isozymes.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-221746	N/A	C22H19N3O5S2	5 mg

• Indirubin-3'-(2,3-dihydroxypropyl)oximether
  c-Src inhibitor blocking downstream STAT3 signalling. Also, induces apoptosis in human cancer cells.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-221752	N/A	C19H17N3O4	1 mg

• Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor
  Benzimidazole compound that acts as a cell-permeable, potent selective inhibitor of IL-1 kinases. Shown to exhibit little activity against a panel of 27 other kinases, including, but not limited to, Ick and src.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-204013	509093-47-4	C20H21N5O4	5 mg

• IPA 3
  A selective cell permeable Pak1 (group I p21-activated kinase) inhibitor which functions by inhibiting activators from binding to the active sites on the enzyme.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-204016	42521-82-4	C20H14O2S2	5 mg/50 mg

• JNK Inhibitor II, Negative Control
  A useful negative control for JNK Inhibitor II. Inhibits JNK2 and JNK3 only at much higher concentrations.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-221781	N/A	C15H10N2O	1 mg

• JNK Inhibitor IX
  A thienylnaphthamide compound that acts as a selective and potent inhibitor of the ATP binding sites of JNK2 and JNK3.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-202671	312917-14-9	C20H16N2OS	5 mg

• JNK Inhibitor V
  Shown to be a nonpeptide ATP competitive inhibitor of JNK signal transduction pathway. Also reported to demonstrate anti-apoptotic capabilities.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-202672	345987-15-7	C20H16N6S	5 mg

• JNK Inhibitor VIII
  A JNK inhibitor that has been reported to suppress apoptosis, caspase cleavage, and cytochrome C release. Studies indicate that the inhibitor can block the phosphorylation of c-Jun and JNKAR1.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-202673	894804-07-0	C18H20N4O4	5 mg

• kb NB 142-70
  kb NB 142-70 is a selective protein kinase D (PKD) inhibitor. Demonstrates a 7-fold increase in inhibition potency as an analog of CID 755673 (sc-205246).

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-358834	N/A	C11H9NO2S2	10 mg/50 mg

• KH CB19

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-362756	N/A	C15H13Cl2N3O2	1 mg

• KI 8751
  Cell-permeable quinolyloxyphenyl-urea compound that acts as a VEGFR-2-selective inhibitor.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203090	228559-41-9	C24H18F3N3O4	5 mg

• KU 60019

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-363284	925701-46-8	C30H33N3O5S	10 mg/50 mg

• L-779,450
  Potent, ATP-competitive Raf kinase inhibitor (IC₅₀ = 10 nM) that displays > 7, > 30 and > 70-fold selectivity over p38α, GSK3β and Lck respectively. Suppresses DNA synthesis and induces apoptosis in cells that proliferate in response to Raf-1 and A-Raf but not B-Raf.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-204046	303727-31-3	C20H14ClN3O	10 mg/50 mg

• Lavendustin C methyl ester

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-221838	N/A	C15H15NO5	1 mg/5 mg

• LFM-A12
  A potent and specific inhibitor of the EGFR tyrosine kinase in vitro (IC50 = 1.7 µM). Has been shown to kill over 99% of human breast cancer cells in vitro by triggering apoptosis. Even at high concentrations (175-350 µM), LFM-A12 does not affect the enzymatic activity of other PTKs including BTK, HCK, IRK, JAK1, JAK3, and Syk.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-295360	N/A	C12H9F3N2O3	500 µg/1 mg

• LFM-A13
  A potent and selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits recombinant BTK with an IC₅₀ value of 2.5 μM and has no activity on other protein kinases ( which include JAK1, JAK3, HCK, EGFR kinase and insulin receptor kinase) at concentrations of up to 278 μM.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203623	62004-35-7	C11H8Br2N2O2	10 mg/50 mg

• Linoleoyl Ethanolamide-d4
  Linoleoyl ethanolamide is an endocannabinoid detected in porcine brain and murine peritoneal macrophages which contains linoleate in place of the arachidonate moiety of arachidonoyl ethanolamide (AEA). It has weak affinity for the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors, exhibiting Ki values of 10 µM and 25 µM, respectively. However, it is only approximately 4-fold less potent than AEA at causing catalepsy in mice (ED50 of 26. mg/kg). In addition, linoleoyl ethanolamide increases ERK phosphorylation and AP-1-dependent transcription approximately 1.-fold at 15 µM in a CB-receptor-independent manner. However, cellular toxicity is readily apparent at concentrations of 10-20 µM. Linoleoyl ethanolamide inhibits human fatty acid amide hydrolase-dependent hydrolysis of AEA with a Ki value of 9.0 µM, but also is hydrolyzed effectively by the enzyme.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-295362	68171-52-8	C20H33D4NO2	100 µg/500 µg

• LY 294002, 4′-NH2
  A cell permeable 4′-amino derivative which inhibits the p110α, p110β, p110δ, and p110γ subunits of Phosphoinositide 3-kinase.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203121	942289-87-4	C19H18N2O3	5 mg/50 mg

• LY 364947
  A diheteroaryl-substituted pyrazole compound used as a selective, ATP-competitive inhibitor of TGF-β Receptor I kinase.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203122	396129-53-6	C17H12N4	5 mg/10 mg

• LY-294,002 hydrochloride

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-215273	934389-88-5	C19H18ClNO3	1 mg/5 mg

• Met Kinase Inhibitor

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-204801	658084-23-2	C28H30ClN5O4S	1 mg

• ML-7
  Shown to be an inhibitor of Ca²⁺ dependent and independent smooth muscle myosin light chain kinases. Also, affects the osmotic volume regulation of cells via stimulation of K-CL cotransport.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-200557	110448-33-4	C15H17IN2O2S··HCl	10 mg/50 mg

• MNS
  A cell-permeable, cytotoxic β-nitrostyrene derivative which functions as a tyrosine kinase inhibitor that supresses human platelet aggregation.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-202229	1485-00-3	C9H7NO4	50 mg

• Myricetin
  A non-ATP competitive MEK1 inhibitor and ATP-competitive inhibitor of CKI, CKII, IR, MLCK, PKA and PKC.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203147	529-44-2	C15H10O8	25 mg/100 mg

• N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide
  Found to have a potent inhibitory action against casein kinase 1 completely with respect to ATP and a much weaker effect on casein kinase 2 and other protein kinases.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-207901	120615-25-0	C11H12ClN3O2S	10 mg

• N-(4-Pyridyl)-N'-(2,4,6-trichlorophenyl)urea
  Potent, selective, and ATP-competitive inhibitor of Rho kinase.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-221970	97627-27-5	C12H8Cl3N3O	5 mg

• N-[2-(p-Cinnamylamino)ethyl]-5-isoquinolone Sulfonamide
  Selective inhibitor of Protein Kinase A (cyclic AMP-dependeant Protein Kinase).

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-207932	130964-40-8	C20H21N3O2S	10 mg

• N-alpha-Benzoyl-L-argininamide hydrochloride
  Shown to be a competitive inhibitor of urokinase and used as a substrate for cathepsin,

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-301278	4299-03-0	C13H19N5O2··HCl	5 g/25 g

• N-Boc-erythro-sphingosine
  The N-Boc protected Sphingosine, a selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets. It does not inhibit protein kinase A or myosin light chain kinase. It inhibits calmodulin-dependent enzymes.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-207996	609812-03-5	C23H45NO4	25 mg

• NFκB Activation Inhibitor VI, BOT-64
  A cell-permeable benzoxathiole compound that acts as an IKK-2 inhibitor, by targeting the Ser177 and/or Ser181 residues in the kinase's activation loop domain.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-222062	N/A	C15H15NO2S	5 mg

• NSC 33994

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-362774	82058-16-0	C28H42N2O2	10 mg/50 mg

• OM137
  An inhibitor of aurora kinases. An aminothiazole derivative, which functions to override the spindle checkpoint primarily through inhibition of the Aurora kinases (mitotic kinases). A more potent inhibitor of Aurora B compared with Aurora A in vitro. The compound has some CDK1 inhibitory activity, but is likely that the major mode by which it drives mitotic exit of cells arrested in M phase via the spindle checkpoint is through its inhibitory activity against Aurora B kinase.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-255403	292170-13-9	C13H14N4O3S	5 mg

• Palmitoyl-L-carnitine Chloride
  Protein kinase inhibitor

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-205789	18877-64-0	C23H45NO4 ·HCl	5 mg/10 mg

• Pamidronate disodium salt hydrate
  A bisphosphonate compound, which inhibits farnesyl diphosphate synthase and bone resorption. This compound stimulates polymorphonuclear leukocyte and platelet derived nitric oxide production.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-272006	57248-88-1 (anhydrous)	C3H9NO7P2Na2 ·H2O	10 mg

• PD 0325901
  A potent MEK inhibitor that suppresses phosphorylation of ERK1/2 in murine colon 26 tumors with an IC50 value of 0.33 nM.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-205427	391210-10-9	C16H14F3IN2O4	500 µg/1 mg

• PD 161570

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-361284	192705-80-9	C26H35Cl2N7O	10 mg/50 mg

• PD 407824
  Selective inhibitor of checkpoint kinases Chk1 and Wee1 (IC₅₀ values are 47 and 97 nM respectively). Displays selectivity over a range of other protein kinases; IC₅₀ values are 3.4, 3.75, > 5, > 50, > 50 and > 50 μM for PKC, CDK4, other CDKs, c-Src, PDGFR and FGFR respectively.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203660	622864-54-4	C20H12N2O3	1 mg/10 mg

• PF 04217903 mesylate

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-363286	956906-93-7	C19H16N8O.CH3SO3H	10 mg/50 mg

• PF 431396

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-362780	717906-29-1	C22H21F3N6O3S	10 mg

• PF 4708671

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-361288	N/A	C19H21F3N6	10 mg/50 mg

• PF 477736

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-362781	952021-60-2	C22H25N7O2	10 mg/50 mg

• PF 4800567 hydrochloride

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-362782	1188296-52-7	C17H18ClN5O2.HCl	10 mg/50 mg

• PF 573228
  A selective and potent focal adhesion kinase inhibitor that reportedly displays 50-250-fold selectivity for FAK over other protein kinases

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-204179	869288-64-2	C22H20F3N5O3S	10 mg/50 mg

• PF 670462
  A selective casein kinase, CK1ε and CK1δ inhibitor which also shows potency against 42 other kinases.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-204180	950912-80-8	C19H20FN5•2HCl	10 mg/50 mg

• PHA 665752
  A small molecule, ATP competitive inhibitor of the catalytic activity of c-Met tyrosine kinase with apoptotic properties.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203186	477575-56-7	C32H34Cl2N4O4S	2 mg

• PI-103
  A cell-permeable pyridinylfuranopyrimidine compound that acts as an ATP-competitive dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR complex 1 and 2.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203193	371935-74-9	C19H16N4O3	1 mg/5 mg

• PIM-1 Inhibitor 2
  Potent Pim-1 kinase inhibitor (Ki = 91 nM).

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-204194	477845-12-8	C17H11CIN4O	10 mg/50 mg

• PKC-412
  Reported to be an antiproliferatiive agent which inhibits protein kinase C. Additionally shown to increase endothelial nitric oxide (NO) synthase expression and NO production.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-200691	120685-11-2	C35H30N4O4	1 mg/5 mg

• PknG Inhibitor
  A cell-permeable tetrahydrobenzothiophene compound that acts as a highly specific and ATP-binding site-targeting inhibitor against mycobacterial protein kinase G (PknG; IC₅₀ = 390 nM), while exhibiting much reduced or no activity against 8 other mycobacterial and 25 other human kinases, including PKCα, the mammalian kinase most closely related to PknG. AX20017 is shown to completely inactivate PknG-mediated blockage of lysosomal transfer and degradation of M. bovis BCG in macrophages at concentrations (10µM or higher) that does not otherwise affect the growth of BCG outside its infected host.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-222180	329221-38-7	C13H16N2O2S	10 mg

• PKR Inhibitor
  The RNA-dependent protein kinase (PKR) inhibitor can inhibit RNA-induced PKR autophosphorylation and rescue PKR-dependent translation block.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-204200	608512-97-6	C13H8N4OS	5 mg

• PKR Inhibitor, Negative Control
  An oxindole compound that serves as a negative control for PKR Inhibitor. Shown to be inactive in inhibiting RNA-induced PKR autophosphorylation (IC₅₀> 100 µM) or in rescuing PKR-dependent translation block.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-204201	852547-30-9	C15H8Cl3NO2	10 mg

• Polo-like Kinase Inhibitor III
  Cell-permeable thiophene-benzimidazole compound that acts as a potent and reversible inhibitor against polo-like kinases.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203202	660868-91-7	C22H18F3N3O4S	500 µg

• PP 3
  Negative control for the Src family protein tyrosine kinase inhibitor PP2. However, it inhibits the activity of EGFR kinase.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203213	5334-30-5	C11H9N5	1 mg

• PP1 Analog II, 1NM-PP1
  Cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203214	221244-14-0	C20H21N5	1 mg/5 mg

• Protein Kinase Inhibitor, DMAP
  Puromycin analog inhibits protein kinases. Inhibits TNF-α upregulation of ICAM-1, lipolysis, and the activation of JNK/SAPK.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203220	938-55-6	C7H9N5	50 mg

• Pseudohypericin
  A specific inhibitor of protein kinase C and D-β-H, an apoptosis inducer, and selective antagonist of corticotropin-releasing factor in murine models.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-202777	55954-61-5	C30H16O9	1 mg/5 mg

• psi-Tectorigenin
  Shown to inhibit EGF-receptor Tyrosine Kinase leading to a block of phosphatidylinositol turnover.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-296865	13111-57-4	C16H12O6	250 µg

• Quercetagetin
  A cell-permeable flavanol compound that acts a potent, ATP-competitive, and reversible inhibitor of PIM1 kinase.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-204221	90-18-6	C15H10O8	5 mg

• Quercetin Dihydrate
  A ubiquitous natural flavonoid with antiproliferative properties. Inhibits PI 3-kinase, PI 4-kinase and PI-4-phosphate 5-kinase, and reduces IP3 levels, blocking oncogenic signaling. Induces apoptosis of cells in G₁ and S.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203225	6151-25-3	C15H10O7 ·2H2O	5 g/25 g

• rac-3-Octadecanamido-2-Methoxypropan-1-ol Phosphocholine
  Shows strong inhibitory action against neoplastic cell growth in vitro. Inhibits Protein Kinase C.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-208288	163702-19-0	C27H57O6N2P•1.5H2O	10 mg

• Raf Kinase Inhibitor IV
  Cell-permeable triarylimidazole compound that acts as a reversible, ATP-competitive, and highly potent inhibitor of Raf kinase.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203233	303727-31-3	C20H14ClN3O•xH2O	1 mg

• Raf Kinase Inhibitor V
  A cell-permeable azaindole compound that acts as a potent, ATP-site targeting and reversible inhibitor of Raf kinase with excellent selectivity over 64-other kinases. Shown to block ERK phosphorylation, induce cell cycle arrest and apoptosis in several B-RafV600E melanoma cells.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-222241	N/A	C17H14ClF2N3O3S	1 mg

• Rho Kinase Inhibitor III, Rockout
  A cell permeable ATP-competitive Rho Kinase inhibitor observed to inhibit the blebbing and promote cell spreading.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203237	7272-84-6	C13H10N2	5 mg

• Rho Kinase Inhibitor IV
  A glycyl analog of Rho-Kinase Inhibitor which inhibits ROCK with an improved selectivity at 6 nM.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-222254	913844-45-8	C18H24N4O3S•2HCl	1 mg

• Rho Kinase Inhibitor V
  A cell-permeable pyrazolyl carboxamide compound that acts as a potent, ATP-binding pocket-targeting inhibitor of ROCK-II and effectively inhibits the myosin light chain 2 phosphorylation on Thr18/Ser19 in A7r5 cells. It affects the activities of PKA, MRCK, Akt1 and CYP-450 enzymes only at much higher concentrations.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-222255	1072906-02-5	C18H15N3O3	5 mg

• Ro-31-8220 in solution

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-358721	138489-18-6	C25H23N5O2S ·CH3SO3H	1 mg

• Rottlerin
  Inhibitor of CaM kinase III, PKC δ, PKC α, PKC β, PKC ε, PKC η and PKC ζ, but with significantly reduced potency; also a hERG activator.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-3550	82-08-6	C30H28O8	10 mg

• Rp-8-CPT-cAMPS
  Lipophilic analog of the competitive inhibitor of protein kinase A (cyclic AMP antagonist).

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-215821	129735-01-9	C16H14ClN5O5PS2 ·Na	5 µmol

• RPI-1
  A competitive, potent ATP-dependent Ret kinase inhibitor. The compound also inhibits c-Met. Increased tumorigenicity, motility, and invasiveness have been described as biological consequences of HGF/Met deregulation in tumor cells, thus not surprisingly RPI-1 treatment of H460 cells resulted in a strong reduction of both colony number and size. The compound is also active at mouse NSCLC H460 xenograft tumor and metastasis model. Mechanistically RPI-1 inhibits Met phosphorylation at Tyr1234/Tyr1235, known to activate the intrinsic kinase activity.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-255524	269730-03-2	C17H15NO4	5 mg

• SB 590885

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-363287	405554-55-4	C27H27N5O2	10 mg/50 mg

• SBE 13 hydrochloride

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-362795	1052532-15-6	C24H27ClN2O4.HCl	10 mg/50 mg

• SC-514
  A selective and reversible inhibitor of IκB kinase 2 (IKK2); displays greater than 10-fold selectivity over 28 other kinases, including JNK, p38, MK2, and ERK.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-205504	354812-17-2	C9H8N2OS2	5 mg/10 mg

• Scytonemin
  An indolic-phenolic pigment and a photo-stable UV shield in prokaryotes. Also found to be an inhibitor of polo-like kinases.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-202337	152075-98-4	C36H20N2O4	1 mg

• SD 1008
  JAK2/STAT3 signaling pathway inhibitor which additionally inhibits Src.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-358791	960201-81-4	C18H19NO5	10 mg/50 mg

• SH-5
  Inhibitor of Akt (PKB) activation without affecting activation of the upstream kinase PDK-1, or other kinases downstream of Ras such as MAPK. Induces apoptosis and kills a variety of cancer cell lines containing high levels of active Akt and depending upon Akt for survival.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-205973	N/A	C29H59O10P	0.5 mg/1 mg

• SH-6
  Inhibitor of Akt (PKB) activation without affecting activation of the upstream kinase PDK-1, or other kinases downstream of Ras (such as MAPK). Induces apoptosis and kills a variety of cancer cell lines containing high levels of active Akt and depending upon Akt for survival.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-205974	N/A	C28H57O9P	0.5 mg/1 mg

• SKI II
  Selective non-lipid inhibitor of sphingosine kinase (IC₅₀ = 0.5 μM); does not act at ATP-binding site. Displays no inhibition of ERK2, PI 3-kinase, or PKCα at concentrations up to 60 μM. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. Induces apoptosis and inhibits proliferation in several other tumor cell lines in vitro (IC₅₀ = 0.9-4.6 μM).

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-204286	312636-16-1	C15H11ClN2OS	10 mg/50 mg

• SL 0101-1
  A selective kinase inhibitor shown to inhibit p90 ribosomal S6 kinase, without inhibiting upstream kinases such as Raf, MEK and PKC.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-204287	77307-50-7	C25H24O12	1 mg

• Smad3 Inhibitor, SIS3
  A cell-permeable pyrrolopyridine compound that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling with no effect on Smad2, p38 MAPK, ERK, or PI 3-K signaling.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-222318	1009104-85-1	C28H27N3O3	1 mg

• SP600125
  Potent, selective and reversible inhibitor of JNK1,-2, and -3. An ATP competitive inhibitor with >20 fold selectivity versus a range of similar kinases.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-200635	129-56-6	C14H8N2O	10 mg/50 mg

• SR 3677 hydrochloride

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-361364	1072959-67-1	C22H24N4O4.HCl	10 mg/50 mg

• ST638
  Protein tyrosine kinase inhibitor that also inhibits HGF-induced MAP kinase activation in hepatocytes. Inhibits phospholipase D activity in human neutrophils.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-202344	107761-24-0	C19H18N2O3S	5 mg

• Staurosporine

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-360258	62996-74-1	C28H26N4O3	100 µl

• STO-609
  A selective ATP-competitive Ca²⁺/calmodulin-dependent protein kinase inhibitor.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-202820	52029-86-4	C19H10N2O3 ·CH3CO2H	5 mg

• SU 3327
  A selective inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 0.7 μM). Shown to inhibit the protein-protein interaction between JNK and JIP (IC50 = 239 nM). Displays selectivity over p38 MAPK and Akt and restores insulin sensitivity in a mouse model of type-2 diabetes.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-296430	40045-50-9	C5H3N5O2S3	10 mg/50 mg

• SU 4312
  SU 4312 is a selective and potent vascular endothelial cell growth factor receptor (VEGFR) inhibitor.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-200637	5812-07-7	C17H16N2O	5 mg/25 mg

• SU 4984
  Inhibitor of tyrosine kinase activity of fibroblast growth factor receptor 1 (FGFR1). Inhibits αFGF-induced tyrosine phosphorylation of ERK1 and ERK2 and the tyrosine phosphorylation of the PDGF receptor and the insulin receptor. Does not inhibit the kinase activity of the EGF receptor.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-205977	186610-89-9	C20H19N3O2	1 mg

• SU 5402
  A FGFR-specific tyrosine kinase inhibitor. Research shows that inhibition of FGFR results in the blocking of NVPs secretion and an increase of Ca2⁺.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-204308	215543-92-3	C17H16N2O3	1 mg/5 mg

• SU1498
  Demonstrates reversible, potent ATP-competitive and selective inhibitor of Flk-1 kinase, a vascular endothelial growth factor (VEGF) receptor kinase. Able to reduce expression of ets-1, a transcription factor stimulated by VEGF. Can potentially act as an angiogenesis inhibitor, as well.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-355982	N/A	C25H30N2O2	5 mg

• SU6656
  A potent, selective Src family kinase inhibitor known to inhibit c-Src, Fyn, c-Yes, Lyn, Lck and PDGF receptor kinase.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203286	330161-87-0	C19H21N3O3S	1 mg

• SX 011
  A selective p38α, p38β and JNK-2 inhibitor.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-358841	309913-42-6	C26H27ClFN3O3	10 mg

• Syk Inhibitor IV, BAY 61-3606
  Cell-permeable imidazopyrimidine. Potent, ATP-competitive, reversible, and highly selective inhibitor of Syk and Syk-mediated cellular functions.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-202351	732983-37-8	C20H21ClN6O4	2 mg

• TAK 715

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-362799	303162-79-0	C24H21N3OS	10 mg/50 mg

• (+/-)-Taxifolin hydrate
  An antioxidant flavenoid.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-258192	24198-97-8	C15H12O7 ·xH2O	25 mg

• TC-A 2317 hydrochloride

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-363291	1245907-03-2	C19H28N6O.HCl	10 mg/50 mg

• TCS 2002

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-359020	1005201-24-0	C18H14N2O3S	10 mg/50 mg

• TCS 21311

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-362804	1260181-14-3	C27H25F3N4O4	10 mg/50 mg

• TCS 2312 dihydrochloride
  Potent and selective checkpoint kinase 1 (chk1) inhibitor (K_i = 0.38 nM, EC₅₀ = 60 nM). Enhances the cell killing activity of Gemcitabine in breast and prostate cancer cell lines. Displays antiproliferative effects in vitro.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-204326	838823-32-8	C25H24N4O2.2HCl	1 mg

• TCS PIM-1 1
  ATP-competitive Pim-1 kinase inhibitor that displays selectivity over Pim-2 and MEK1/2 (IC₅₀ values are 50, > 20000 and > 20000 nM for Pim-1, Pim-2 and MEK1/2 respectively).

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-204330	N/A	C18H11BrN2O2	10 mg/50 mg

• TCS PIM-1 4a
  A selective, ATP-competitive Pim kinase inhibitor (IC50 values are 24 and 100 nM for Pim-1 and Pim-2 respectively). Shown to display selectivity over a panel of ~50 other kinases tested. Also exhibits cytotoxicity in PC3 prostate carcinoma cells in vitro (IC50 = 17 μM).

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-296450	438190-29-5	C11H6F3NO2S	10 mg/50 mg

• Terreic Acid
  Terreic acid is a metabolite that displays antibiotic properties. It has been found to inhibit the catalytic activity of BTK.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-200655	121-40-4	C7H6O4	1 mg/5 mg

• TG 003

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-362808	719277-26-6	C13H15NO2S	10 mg/50 mg

• TGF-β RI Kinase Inhibitor III
  A cell-permeable imidazolyl-pyridine compound that acts as a potent, ATP-competitive, reversible, and selective inhibitor of activin receptor-like kinase 4 (IC50 = 129 nM), 5 ( IC₅₀ = 47 nM), and 7. It inhibits p38 MAPKα only at much higher concentrations (IC₅₀ = 10.6 µM) and has little effect against ALK1/2/3/6 as well as a panel of 26 other kinases.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-204341	356559-13-2	C20H21N3O2 ·HCl	2 mg

• TGF-β RI Kinase Inhibitor V
  A selective and reversible inhibitor, which suppresses TGF-β RI/ALK5 signaling.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203294	627536-09-8	C17H10ClFN6	2 mg

• TGF-β RI Kinase Inhibitor VIII
  Cell-permeable quinoxaline compound that is an ATP-competitive inhibitor against type I TGF-βreceptor TbR-I/ALK5.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203295	356559-20-1	C21H21N5	2 mg

• TMCB

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-361383	905105-89-7	C11H9Br4N3O2	10 mg/50 mg

• Torin 2

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-362811	1223001-51-1	C24H15F3N4O	10 mg/50 mg

• Tozasertib

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-358750	639089-54-6	C23H28N8OS	25 mg/50 mg

• Tpl2 Kinase Inhibitor
  Tpl2 Kinase Inhibitor is a reversible naphthyridine ATP-competitive inhibitor of the enzyme Tpl2 kinase. The enzyme is a hematopoietically expressed serine-threonine kinase responsible for regulating tumor necrosis factor-α, toll-like receptor, and G protein–coupled receptor signaling.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-204351	871307-18-5	C21H14ClFN6	1 mg

• Triciribine
  Known to suppress the phosphorylation level and kinase activity of Akt. Selectively inhibits Akt1, -2, and -3 without inhibiting known upstream activators, PDK1 and PI 3-Kinase, of Akt.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-200661	35943-35-2	C13H16N6O4	1 mg/5 mg

• TX-1123
  May be useful as a therapeutic agent for cancer treatment in animal models. A cell-permeable, reversible and substrate-competitive arylidene-cyclopentenedione derived tyrphostin that acts as a kinase inhibitor for Src, eEF2-K, and PKA (IC50 = 2.2, 3.2, and 9.6 µM, respectively). Has been shown to inhibits EGFR-K and PKC, but only at much higher concentrations (IC50 = 320 µM). Reported to exhibit potent anti-tumor activity (EC50 = 3.66 and 39 µM in HepG2 and HCT116 tumor cells, respectively) with greatly reduced mitochondrial- (≥1000-fold) and hepato-toxicity (≥50-fold) when compared with another tyrphostin, AG 17 (sc-200568 and sc-200568A).

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-296675	157397-06-3	C20H24O3	10 mg

• TWS 119 ditrifluoroacetate

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-358727	601514-19-6 (non-salt)	C18H14N4O2•2CF3CO2H	10 mg

• TX-1918
  May be useful as a therapeutic agent for cancer treatment in animal models. A cell-permeable arylidene-cyclopentenedione derived tyrphostin that acts as a potent inhibitor for eEF2-K (IC50 = 440 nM). Has been shown to inhibit other kinases at much higher concentrations (IC50 = 4.4, 44, 44, and 440 µM for Src, PKA, PKC, and EGFR-K, respectively). Reported to exhibit potent anti-tumor activity (EC50 = 2.07 and 230 µM in HepG2 and HCT116 tumor cells, respectively) with greatly reduced mitochondrial- (≥5000-fold) and hepato-toxicity (≥90-fold) when compared with another tyrphostin, AG 17 (sc-200568 and sc-200568).

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-296676	N/A	C14H12O3	10 mg

• Tyrene CR4
  Cell-permeable, reversible, and substrate competitive hydroxystryrylacrylonitrile tyrosine kinase inhibitor that show anti-tumor properties. Potently inhibits the kinase activities of JAK2 and Bcr-Abl (IC50 ~100-600 nM and 500-700 nM, respectively). Displays excellent selectivity over other tyrosine kinases, Btk, Lck, Lyn, Src, Syk and ZAP-70 (IC50 >5 µM). Has been shown to preferentially induce apoptosis in acute lymphoblastic (ALL) and myeloid leukemia cells (AML), while exhibiting little deleterious effect towards normal bone marrow cell differentiation and proliferation. Has been reported to be more potent than AG 490 (sc-202046) in inducing ALL cells growth arrest (IC50 ~ 120 nM vs. 5-25 µM). Its in vivo efficacy in cancer reduction has been successfully demonstrated in NOD-SCID mice engrafted with human Ph+ ALL cells.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-296677	N/A	C19H16N2O3	5 mg

• Tyrphostin 9 (RG-50872, Malonaben, SF 6847)
  Reported to be tyrosine kinase protein inhibitor and potent reversible inhibitor of PDGF-induced mitogenesis.Also reported to inhibit actin ring formation and bone resorption in murine osteoclasts.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-200568	10537-47-0	C18H22N2O	50 mg/250 mg

• Tyrphostin AG 1433
  A specific and potent inhibitor of PDGF-β receptor kinase (IC₅₀ = 5.0 µM) and of KDR/Flk-1/VEGF Receptor 2 (IC₅₀ = 9.3 µM). Also acts as angiogenesis inhibitor.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-205984	168836-03-1	C16H14N2O2	1 mg/5 mg

• Tyrphostin B42
  A potent inhibitor of the JAK-2 tyrosine kinase that preferentially inhibits JAK-2 over other kinases.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-3556	133550-30-8	C17H14N2O3	5 mg

• U0124
  Inactive analog of U0126. Used as a negative control. Doesn’t inhibit MEK at concentrations up to 100 μM.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-204934	108923-79-1	C8H10N4S2	10 mg

• UCN-01
  A Staurosporine (sc-3510) analogue that acts as a selective inhibitor of protein kinase C, potently inhibits MK2, induces UCN-01 G₁ phase accumulation, dephosphorylates Rb and CDK2 proteins, and induces CDK inhibitor p21/Cip1/WAF1/Sdi1.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-202376	112953-11-4	C28H26N4O4	500 µg

• UCN-02
  Indolocarbazole isolated as a minor co-metabolite of high producing staurosporine strains of selected actinomycetes. Less selective than isomer UCN-01, UCN-02 exhibits comparable activity.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-202377	121569-61-7	C28H26N4O4	500 µg

• VEGF Inducer, GS4012
  This is a cell-permeable pyridinyl-thioether compound which acts as a potent inducer of VEGF and VEGF-mediated vessel formation. GS4012-induced upregulation of VEGF correlates well with its ability to suppress the gridlock/coarctation phenotype (7.5 µg/ml) in Zebrafish as well as to stimulate tubule network formation (5 µg/ml) in HUVECs.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-222411	N/A	C14H15NOS ·HCl	10 mg

• VX 702

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-361400	479543-46-9	C19H12F4N4O2•xH2O	10 mg

• W-12, Hydrochloride
  Calmodulin antagonist that inhibits myosin light chain kinase and Ca²⁺-calmodulin-dependent phosphodiesterase.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-203309	89108-46-3	C14H18N2O2S ·HCl	1 mg

• XMD 8-92

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-361408	1234480-50-2 (free base)	C26H30N6O3 ·C2HF3O2	10 mg/50 mg

• Y-27632 dihydrochloride monohydrate
  A potent, cell-permeable, ROCK (Rho-associated coiled coil forming protein serine/threonine kinase) inhibitor, that has also been shown to, ATP-competively, inhibit ROCK-II.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-216067	331752-47-7	C14H21N3O ·2HCl ·H2O	1 mg/5 mg

• ZM 323881 hydrochloride
  A potent and selective inhibitor of human vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) activity. Inhibits VEGF-A-induced endothelial cell proliferation in vitro (IC50 = 8 nM). Selectively inhibits VEGFR-2 (IC50 = 2 nM) over VEGFR-1 and a range of other receptor tyrosine kinases such as PDGFRβ, FGFR1, EGFR and erbB2 (IC50 > 50 μM).

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-296861	324077-30-7	C22H18FN3O2•HCl	1 mg/10 mg

• ZM 336372
  A reversible tyrosine kinase modulator selectively inhibiting protein kinase c-Raf.

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-202857	208260-29-1	C23H23N3O3	1 mg

• ZM-306416
  VEGF receptor tyrosine kinase inhibitor. Inhibits KDR (IC₅₀= 100nM ) and Flt (IC₅₀= 2µM) tyrosine kinases .

  Catalog #	CAS Number	Molecular Formula	Unit
  sc-200676	690206-97-4	C16H13ClFN3O2	1 mg/10 mg