Welcome to Santa Cruz Biotechnology!
SCBT Home
Home » Chemicals » Ion Pump Reagents

Ion Pump Reagents

Introducing HOVERcruz™,

a unique system for rapid identification of chemicals of interest. Hover over product names in the table to see representative images for each product.

Live chat is now available! (click here)

Our live chat system is available to answer your product and ordering questions.

PRODUCT NAMECATALOG #DESCRIPTIONCITATIONSRANKING
3-Benzidino-6-(4-chlorophenyl)pyridazinesc-2544283-Benzidino-6-(4-chlorophenyl)pyridazine is an inhibitor of delayed rectifier and transient outward potassium currents. The IC50 values for the blocking action of BCP on IKDR and IKA was calculated as 7.13 µM and 0.55 µM, respectively in acutely isolated rat hippocampal pyramidal neurons by employing whole-cell patch-clamp technique. CAS # 901773-91-9

3-formylrifamycin SVsc-204879A derivative of rifamycins found to interact with biological membranes. It causes a change in permeability to K+ and H+ in the mitochondrial membrane. CAS # 13292-22-3

5’-Iodoresiniferatoxinsc-2020245'-Iodoresiniferatoxin is an inhibitor of VR.

BNTX maleatesc-203850BNTX maleate is a selective δ1 opioid receptor (DOR) antagonist. BNTX maleate inhibits neurogenic ion transport in porcine ileal mucosa. CAS # 129468-28-6

Bromoacetylcholine bromidesc-252517Used as an affinity alkylating agent for nicotinic receptors. CAS # 22004-27-9

Bufalinsc-200136An inducer of U937 and HL-60 apoptosis and cell differentiation by activation of AP-1 via a MAPK pathway. CAS # 465-21-4

Bumetanide (Ro 10-6338)sc-200727Bumetanide is a specific inhibitor of Na+-K+-2Cl- cotransporter NKCC1, which has been shown to bind with high affinity and saturate binding of the cotransporter. CAS # 28395-03-1

CBIQsc-252550An activator of the cystic fibrosis transmembrane conductance regulator (CFTR) and the intermediate-conductance calcium-sensitive K+ channel (KCNN4). May act as a novel tool for a new ion channel. First activator of F508 CFTR, the mutant form of CFTR chloride channel present in 75% of cystic fibrosis patients. Other benzoquinolines act at the normal CFTR but not at F508 CFTR. CBIQ also activates KCNN4, which hyperpolarizes airway epithelial cells to promote anion flux, a further benefit in cystic fibrosis. CAS # 32081-28-0

Cibenzoline succinatesc-362179A class IA antiarrhythmic that blocks ATP-sensitiv K channels in pancreatic and heart cells in the µM concentrations. It has also been shown to interact with the K(ATP) channel pore-forming subunit from the cytoplasmic side and inhibits the delayed rectifier K current [I/(Kr)] in sino-atrial node cells. CAS # 100678-32-8

Clopamidesc-201553Clinically useful diuretit. Clopamide selectively inhibits the chloride the sodium chloride cotransporter. CAS # 636-54-4

(-)-Cotininesc-205267Major nicotine metabolite. Exhibits cognition-enhancing effects in vivo.Activates a subpopulation of α3/α6β2 nAChRs in monkey striatum. CAS # 486-56-6

DBO-83sc-252663A novel nicotinic acetylcholine receptor agonist. Structurally related to epibatidine. Has antinociceptive properties in rodents. CAS # 195211-53-1

DK-AH 269sc-252761An HCN Channel blocker; an open channel blocker of neuronal Ih and related cardiac If channels. CAS # 186097-54-1

(+)-Epibatidine dihydrochloridesc-252777A non-opioid analgesic alkaloid isolated from skin of Ecuadoran tree frog, Epipedobates tricolor; naturally-occurring isomer of the most potent nicotinic acetylcholine receptor agonist known. Discoveries in the nAChR field have stimulated interest in nAChR-targeted compounds as potential analgesic agents. Epibatidine has full efficacy relative to opioids in preclinical pain models. Although epibatidine is toxic, these observations demonstrated that modest efficacy is not a general limitation of nAChR agonists. Moreover, exploration of the molecular biology of nAChRs revealed evidence of receptor diversity, which suggest that nAChR subtype-selective agents are less toxic than nicotine; and early medicinal chemistry efforts have resulted in compounds with improved safety profiles. CAS # 166374-43-2

Esomeprazole magnesium dihydratesc-252785A leading proton pump inhibitor. CAS # 217087-10-0

Fura 2 magnesium-selective analog tetrapotassium saltsc-252842A cell impermeable fluorescent probe for Mg+2 CAS # 132319-57-4

Glimepiridesc-203058Glimepiride is a third generation sulfonylurea compound, which increases the release of insulin from pancreatic beta cells and blocks KIR channels. CAS # 93479-97-1

Lidoflazinesc-255253Lidoflazine is an antianginal calcium channel protein inhibitor that carries a significant risk of QT interval prolongation and ventricular arrhythmia. CAS # 3416-26-0

Glycine sodium saltsc-257565An inhibitory neurotransmitter in the spinal cord which is an allosteric regulator of NMDA receptors. CAS # 6000-44-8

Kainic acid monohydratesc-269283Kainate class of ionotropic glutamate receptor agonist. Has been shown to induce seizures and neurodegeneration in vivo and has also been used to induce experimental epilepsy in rodents and to examine excitation-induced neuronal apoptosis mechanisms. CAS # 58002-62-3

Levosimendansc-204792A Ca(2+) sensitizer that increases contractile force of the myocardium by enhancing the sensitivity of myofilaments to calcium without increasing intracellular calcium concentration. Shown to reduce circulating proinflammatory cytokine interleukin-6 and soluble apoptosis mediators. CAS # 141505-33-1

Mephetyl tetrazolesc-255261Mephetyl tetrazole is a potent and selective Kv1.5 potassium channel blocker. IC50 = 330 nM; shows selective atrial prolongation (40%) of effective refractory period (ERP), and no effect on ventricular ERP Kv1.5 channel is a molecular target for the treatment of atrial fibrillation. CAS # 916923-10-9

N-Methyl Pantoprazole, mixture of 1 and 3 isomerssc-212226An impurity of CAS # 624742-53-6

Ouabain Octhahydratesc-201548Shown to inhibit Na+/K+-ATPase which is an important sodium pump in the eye as well as cardiac and smooth muscles of the heart. CAS # 11018-89-6

9
Pantoprazolesc-204830A proton pump inhibitor which inhibits vesicular gastric H+/K(+)-ATPase under acid transporting conditions by accumulating in the pump generated acid space. It also inhibits acid secretion. CAS # 102625-70-7

Pantoprazole Sodiumsc-204831A gastic proton pump inhibitor. CAS # 138786-67-1

Prilocaine hydrochloridesc-253317Employed for local nerve block and for spinal anesthesia; pharmacological properties are similar to those of lidocaine. CAS # 1786-81-8

Quene 1-AMsc-253334A fluorescent probe for intracellular pH. CAS # 86293-31-4

R(+)-Verapamil monohydrochloride hydratesc-253359Less active enantiomer of ±Verapamil; Inhibitor of P-glycoprotein. CAS # 38176-02-2 (anhydrous)

Rabeprazolesc-204872A proton pump/ATP-ase inhibitor. CAS # 117976-89-3

Stevioside hydratesc-272502A natural, noncaloric sweetener with a potency 300 times more than that of regular sucrose that is found in plants of the Stevia sp. CAS # 57817-89-7 (anhydrous)

Supercinnamaldehydesc-253616Supercinnamaldehyde is a transient receptor potential ankyrin 1 (TRPA1) activator, EC50= 0.8 µM, derivative of cinnamaldehyde, covalently binds to and activates TRPA1 receptor (expressed in nociceptive neurons) by modifying its cysteine residues. Covalent modification of reactive cysteines within TRPA1 can cause channel activation, and rapid signaling potential tissue damage through the pain pathway. CAS # 70351-51-8

Tenatoprazolesc-204909A proton pump inhibitor. CAS # 113712-98-4

Tetracainesc-255645Topical ophthalmic anesthetic that is used for spinal anesthesia Blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum. CAS # 94-24-6

Tofisopamsc-253708A ligand for the GABAA receptor benzodiazepine modulatory site. CAS # 22345-47-7

TRO 19622sc-204356TRO 19622 is a neuroregenerative and neuroprotective compound. This compound promotes nerve regeneration following sciatic nerve crush and rescues motor neurons from axotomy-induced cell death. TRO 19622 binds directly to two components of the mitochondrial permeability pore, the voltage-dependent anion channel (VDAC) and translocator protein. CAS # 22033-87-0

UK 5099sc-361394UK 5099 is an inhibitor of the mitochondrial pyruvate carrier (MPC) and plasma membrane monocarboxylate transporters (MCTs). CAS # 56396-35-1

VU0240551 sc-253834A potent, selective KCC2 inhibitor. CAS # 893990-34-6

ZD 7288sc-361419ZD 7288 has been reported to block Ih in central neurons, and inhibit the hyperpolarization activated cation current If. CAS # 133059-99-1

Zomepirac sodium saltsc-253856An NSAID that circumvents MRP-mediated multidrug resistance. Increases the cytotoxicity of the anthracyclines (doxorubicin, daunorubicin and epirubicin), as well as teniposide, VP-16 and vincristine. CAS # 64092-48-4

Lansoprazolesc-203101H+,K+-ATPase inhibitor that displays antisecretory and antiulcer activity. Inhibits gastric acid secretion. CAS # 103577-45-3