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AY 9944
Blocks cholesterol biosynthesis and esterification. Specifically blocks 7-dehydrocholesterol reductase activity.
Catalog # CAS Number Molecular Formula Unit
sc-202965 366-93-8 C₂₂H₂₈Cl₂N₂•2HCl 5 mg
Hh/Gli Antagonist, GANT58
A cell-permeable tetrapyridinylthiophene compound that acts as downstream Hedgehog (Hh) pathway blocker and targets Gli-mediated gene transactivation (IC₅₀ ~ 5 µM in SAG-stimulated Shh-L2 cells). Shown to reduce cellular mRNA levels of Hh target genes, Gli1, Hip1,& Ptch, and inhibit Gli-dependent tumor growth both in vitro and in vivo. Its action appears to be Hh pathway-selective, downstream of Smo and Sufu, but does not seem to interfere with Gli DNA binding.
Catalog # CAS Number Molecular Formula Unit
sc-221723 N/A C₂₄H₁₆N₄S 5 mg
Cyclopamine
A teratogen natural product, inhibits smoothened protein of the hedgehog (Hh) signaling pathway, leading to improper fetus differentiation and cyclopia. Can also suppress smoothened hyperactivity and related oncogenesis.
Catalog # CAS Number Molecular Formula Unit
sc-200929 4449-51-8 C₂₇H₄₁NO₂ 1 mg/5 mg
Cyclopamine-KAAD
A potent, cell-permeable analog of Cyclopamine that specifically inhibits the Hedgehog (Hh) signaling with similar or lower toxicity. Binds to SmoA1 and promotes its exit from the endoplasmic reticulum. Suppresses both the ShhNp-induced pathway activity and SmoA1-induced reporter activity.
Catalog # CAS Number Molecular Formula Unit
sc-221448 N/A C₄₄H₆₃N₃O₄ 100 µg
Despiro Cyclopamine
An analogue of Cyclopamine, a sonic hedgehog inhibitor.
Catalog # CAS Number Molecular Formula Unit
sc-218162 N/A C₂₇H₄₁NO₂ 1 mg
GANT 58
A GLI antagonist and an inhibitor of GLI induced transcription.
Catalog # CAS Number Molecular Formula Unit
sc-358832 64048-12-0 C₂₄H₁₆N₄S•xH₂O 10 mg/50 mg
GANT61
Reported to be an inhibitor of GLI-mediated transcription and therefore a suppressor of the Hedgehog signaling pathway.
Catalog # CAS Number Molecular Formula Unit
sc-202630 500579-04-4 C₂₇H₃₅N₅ 1 mg
HPI-4
Catalog # CAS Number Molecular Formula Unit
sc-358720 302803-72-1 C₁₇H₉Cl₂N₃O₂ 5 mg/25 mg
Jervine
Jervine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog signaling.
Catalog # CAS Number Molecular Formula Unit
sc-200934 469-59-0 C₂₇H₃₉NO₃ 1 mg/5 mg
N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[[3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl]methyl]urea
A potent modulator of Hedgehog (Hh) protein function and a nanomolar Hh antagonist.
Catalog # CAS Number Molecular Formula Unit
sc-212054 330796-24-2 C₂₃H₁₅ClF₄N₄O₂ 1 mg
Octyl Maleimide
A sonic hedgehog inhibitor. Also a possible inhibitor of prostaglandin endoperodixide synthases.
Catalog # CAS Number Molecular Formula Unit
sc-208128 4080-76-6 C₁₂H₁₉NO₂ 500 mg
Oxy-16
A cell permeable oxysterol that may be used for cholesterol transport across cell membranes. Also shown to be a Hedgehog signaling pathway activator.
Catalog # CAS Number Molecular Formula Unit
sc-358805 596-94-1 C₂₇H₄₆O₃ 1 mg/5 mg
SANT-2
Cell permeable antagonist of the Smoothened (Smo) protein function. Inhibitor of SAG activity. Chemical tool to study the Hedgehog (Hh) signalling pathway.
Catalog # CAS Number Molecular Formula Unit
sc-202801 329196-48-7 C₂₆H₂₆ClN₃O₄ 1 mg
U 18666A
Alters intracellular membrane protein trafficking by impairing intracellular biosynthesis and transport of LDL-derived cholesterol.
Catalog # CAS Number Molecular Formula Unit
sc-203306 3039-71-2 C₂₅H₄₁NO₂ ·HCl 10 mg
Veratramine, HCl, V. californicum
This compound is a cell-permeable steroidal alkaloid that is structurally related to and is reported to serve as a suitable inactive control for Cyclopamine, Cyclopamine-KAAD (sc-221448), and Jervine in Shh (sonic hedgehog) signaling studies.
Catalog # CAS Number Molecular Formula Unit
sc-356191 1258005-82-1 C₂₇H₃₉NO₂•HCl 5 mg