Gene Regulation Reagents

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PRODUCT NAME	CATALOG #	DESCRIPTION	CITATIONS	RANKING
Actinomycin D	sc-200906	Actinomycin D is a metabolite isolated from Streptomyces parvulus that binds to the GpC steps of DNA. The compound acts as an RNA polymerase inhibitor and an antibiotic. CAS # 50-76-0	1
10074-G5	sc-213578	Specifically inhibits c-Myc oncoprotein and Mac coupled folding and binding; slightly more potent than 10058-F4. CAS # 413611-93-5
I-BET 151 Hydrochloride	sc-391115	I-BET 151 Hydrochloride is a BET bromodomain (BRD) inhibitor and blocks recruitment of BET to chromatin. CAS # 1300031-49-5
7-Aminoactinomycin D	sc-221210	7-Aminoactinomycin D (7-AAD) is a fluorescent DNA dye which is useful for quantifying apoptosis. 7-AAD has also been used in studies on cellular necrosis, chromosome analysis and in cell cycle studies. CAS # 7240-37-1
BAY 11-7082	sc-200615	BAY 11-7082 is an irreversible, potent NF κ B inhibitor show to be a potential anti-inflammatory agent and apoptosis inducer. CAS # 19542-67-7	10
5-Aza-2′-Deoxycytidine	sc-202424	5-Aza-2′-Deoxycytidine inhibits methylation of newly synthesized DNA by specifically inhibiting Dnmt. This is important in determining apoptotic susceptibility to histone deacetylase inhibitors. CAS # 2353-33-5	1
9-cis-Retinoic acid	sc-205589	A vitamin A analog that inhibits cell proliferation and induces cell differentiation. CAS # 5300-03-8
β-Amanitin	sc-202860	A toxic constituent of Amanita phalloides that inhibits eukaryotic RNA polymerase II and III and bacterial RNA polymerase thus inhibtting protein synthesis. CAS # 21150-22-1
B2	sc-202486	B2 is a cell permeable inhibitor of SIRT2 (sirtuin 2) (IC50 = 35 μM). B2 promotes inclusion formation in cellular models of both Huntington’s disease and Parkinson’s disease. CAS # 115687-05-3
A1120	sc-300151	A1120 is a selective non-retinoid ligand for retinol-binding protein 4 (RBP4). RBP4 transports retinol from the liver to extrahepatic tissues.
BADGE	sc-202487	BADGE is an inhibitor of the peroxisome proliferator-activated receptor (PPAR)-γ and adipocyte differentiation, and has been shown to induce apoptosis in tumor cells. CAS # 1675-54-3	1
α-Amanitin	sc-202440	α-Amanitin is the major toxic bicyclic octapeptide of the Amanita phalloides mushroom. This compound is an inhibitor of RNA polymerase II. CAS # 23109-05-9	6
AG-041R	sc-205202	A potent gastrin/CCKB receptor antagonist that exhibits selective binding for CCKB compared to CCKA. CAS # 199800-49-2
8-Chloroadenosine 3',5'-Cyclic Monophosphate sodium salt	sc-202437	8-Chloroadenosine 3',5'-Cyclic Monophosphate sodium salt is a site-selective cAMP analog that inhibits various cancer cell lines due to selective activation of PKA. CAS # 41941-56-4
BML-266	sc-221371	BML-266 is an inhibitor of SIRT2. CAS # 96969-83-4
AMI-1 sodium salt hydrate	sc-300192	Experimentally shown to inhibit arginine, in vitro, with no inhibitory effect on lysine. No effect has been shown against S-adenosyl methionine (AdoMet), contrary to most methyltransferase inhibitors that show active competition for the AdoMet binding site. Studies have demonstrated AMI-1 to prevent cellular arginine methylation, modulate nuclear receptor-regulated transcription from estrogen and androgen response elements, and is a HIV-1 reverse transcriptase inhibitor.
BePl	sc-319856	Has been shown to electively intercalate into triple-helical DNA.
CB 1954	sc-214672	A prodrug used in gene therapy research and activated by NAD(P)H quinone oxidoreductase 2. CAS # 21919-05-1
BML-210	sc-221369	BML-210 has been shown to inhibit HDAC activity in HeLa nuclear extracts (IC50 = 5-10μM). CAS # 537034-17-6
Delavirdine mesylate	sc-200919	Delavirdine mesylate is a nonnucleoside reverse transcriptase inhibitor that displays pH-dependent solubility characteristics. Also shown to not efficiently cross the blood-brain barrier. CAS # 147221-93-0
DIF-1	sc-221541	This compound supresses cell growth and promotes retinoic acid-induced cell differentiation in HL-60 cells.
Mitomycin C	sc-3514	Mitomycin C is a DNA crosslinking and damaging agent that inhibits DNA synthesis and induces apoptosis in a variety of cells via a p53-dependent pathway and activation of caspase-3, caspase-8, and caspase-9. CAS # 50-07-7	9
Dihydromyristicin	sc-202580	Hydrogenated product of myristicin, a natural constituent of parsley. Inducer of glutathione S-transferases. CAS # 52811-28-6
Hoechst-33342·3HCl (Bisbenzimide)	sc-200908	Hoechst-33342·3HCl (Bisbenzimide) is an AT-specific DNA minor groove ligand that is a widely used fluorochrome for visualizing cellular DNA. CAS # 23491-52-3
Imipenem Monohydrate	sc-205350	A third generation cephalosporin antibiotic. Studies show that loss of the OprD porin protein leads to Imipenen resistance in Pseudomonas aeruginosa. CAS # 64221-86-9
LED209	sc-205368	A potent conserved membrane histidine sensor kinase (QseC) inhibitor that blocks both norepinephrine- and epinephrine-triggered QseC-dependent virulence gene expression. CAS # 245342-14-7
Oleylethanolamide	sc-201400	Oleylethanolamide is a naturally occurring lipid analogue of the endogenous cannabinoid anandamide (sc-200790). It has been noted to cause activation of Neu/ErbB2 receptors. This compound has also been shown to be an activator of PPARα CAS # 111-58-0
Hypoxia Inducible Factor-1α Inhibitor	sc-205346	Hypoxia Inducible Factor-1α Inhibitor is a novel small molecule which inhibits HIF by reducing HIF-1α accumulation and gene transcriptional activity. CAS # 934593-90-5
Leptomycin B, Free Acid	sc-202210	Shown to be a potent and specific nuclear export inhibitor. Also an antibacterial agent reported to block the cell cycle of rat fibroblasts at G1 and G2 phases. CAS # 87081-35-4
Lycorine·HCl	sc-200917	Shown to be an inhibitor of viral protein synthesis and peptidyl transferase center. Additionally found to block α 1-adrenoceptors. CAS # 2188-68-3
N-(β-ketocaproyl)-L-Homoserine lactone	sc-205396	Found to be apart of the Quorum sensing regulatory system; employed by numerous bacterial species in cell-to-cell communication. CAS # 143537-62-6
N-3-oxo-tetradec-7Z-enoyl-L-Homoserine lactone	sc-205401	A bacterial quorum sensing compound that possesses antimicrobial activity, the ability to inhibit biofilm formation, and exhibits immune suppressive activity. CAS # 482598-46-9
N-butyryl-L-Homoserine lactone	sc-205402	A small diffusible signaling molecule involved in quorum sensing, controlling gene expression, and cellular metabolism. CAS # 67605-85-0
GW 1929	sc-202640	GW 1929 is a potent, tyrosine-based peroxisome PPARγ (proliferator-activated receptor γ) agonist (EC50 = 13 nM for murine receptor and 6.2 nM for human receptor in cell-based transactivation assays). CAS # 196808-24-9
N-hexanoyl-L-Homoserine lactone	sc-205405	A small diffusible signaling molecule involved in quorum sensing, controlling gene expression, and affecting cellular metabolism. This molecule regulates virulence in general and in cystic fibrosis, prevents infection, reduces slime and biofilm in commercial agriculture and aquaculture industries, prevents food spoilage, and septicemia in fish. CAS # 147852-83-3
O6-Benzylguanine	sc-202747	Effective substrate and efficient inactivator of DNA alkyltransferase. CAS # 19916-73-5
Rifampin, gamma irradiated	sc-296271	Shown to specifically inhibit DNA-dependent bacterial but not mammalian RNA Polymerase. CAS # 13292-46-1
Smoothened Agonist, HCl	sc-202814	Smoothened Agonist, HCl is a highly potent activator of Smo and a Hedgehog pathway agonist from the chlorobenzothiophene family. CAS # 364590-63-6	10
M 344	sc-203124	M344 is a potent HDAC inhibitor with IC50 of 100 nM. CAS # 251456-60-7	8
RNA Polymerase III Inhibitor	sc-222257	A cell-permeable indazolo-sulfonamide compound that displays broad-spectrum inhibitory activity against RNA Polymerase III. Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription. CAS # 577784-91-9
Mithramycin A	sc-200909	Mithramycin A is a DNA/RNA polymerase inhibitor, DNA binding transcriptional inhibitor, antibiotic and observed to facilitate TNF-α and Fas-ligand induced apoptosis. CAS # 18378-89-7
Blasticidin A	sc-202082	An antibiotic that strongly inhibits aflatoxin production by specific fungi via reduction of expression of genes encoding aflatoxin biosynthesis enzymes. CAS # 100513-53-9
RG 108	sc-204235	RG 108 is a non-nucleoside DNA methyltransferase (Dnmt) inhibitor that blocks the enzyme active site. RG 108 inhibits DNA methylation. CAS # 48208-26-0
Pioglitazone	sc-202289	Pioglitazone has been shown to be a PPARγ1 and PPARα activator. In vitro it has been noted that this agent promotes adipocyte differentiation of mesenchymal and preadipocyte stem cell lines. CAS # 111025-46-8	2
Rifampicin	sc-200910	Rifampicin is an antibiotic that potently inhibits RNA polymerase, blocks RNA synthesis in Escherichia coli, and activates PXR. CAS # 13292-46-1	2
Rosiglitazone	sc-202795	Rosiglitazone is a potent, selective PPARγ agonist which exhibits anti-diabetic and hepatoxic effects. Increases insulin sensitivity in muscle and adipose tissue, and plays a functional role in adipogensis. CAS # 122320-73-4	5
(+)-cis,trans-Abscisic acid	sc-202103	A natural and active isomer of the abscission accelerating plant hormone. CAS # 21293-29-8
Toxin A, Clostridium difficile	sc-222361	Toxin A, Clostridium difficile is an inhibitor of Cdc42, Rac and Rhodopsin.
LXRα/β Agonist	sc-221864	LXRα/β Agonist is a cell-permeable maleimide analog which acts as a potent and specific LXR (liver X receptor) dual agonist.
Levofloxacin hydrochloride	sc-202693	A fluoroquinolone antibiotic agent, the active S-(-) isomer of the antibacterial agen ofloxacin. Inhibits DNA gyrase and topoisomerase IV activity. CAS # 177325-13-2
Procysteine	sc-200811	Procysteine is a glutathione (GSH) precursor that links GSH synthesis and metabolism. Also found to stimulate expression of insulin-like growth factor-1, cariotrophin-1, and ciliary neurotrophic factor. CAS # 19771-63-2
AK-7	sc-364096	AK-7 is an inhibitor of SIRT2. CAS # 420831-40-9
Linoleic Acid	sc-200788	Linoleic Acid is a fatty acid that has been observed to influence the inflammatory process and regulate the functions of neutrophils. CAS # 60-33-3	1
Histone Lysine Methyltransferase Inhibitor	sc-202651	Histone Lysine Methyltransferase Inhibitor (BIX-01294) is a G9a ( HMTase) inhibitor, suppressing H3K9me2 generation by G9a. Does not compete with S-adenosyl-methionine cofactor. CAS # 935693-62-2 (hydrate)
Triphenyl Compound A	sc-364144	Triphenyl Compound A is an inhibitor of pirin. CAS # 21306-65-0
Neurodazine	sc-222056	Neurodazine is a cell-permeable trisubstituted imidazole compound that induces neurogenesis of non-pluripotent C2C12 myoblasts as well as cells derived from mature human skeletal muscle cultures. CAS # 937807-66-4
3-Deazaneplanocin, HCl salt	sc-351856	3-Deazaneplanocin, HCl salt is a carbocyclic analog of adenosine that acts as an effective SAHH (S-adenosylhomocysteine hydrolase) inhibitor. CAS # 102052-95-9
GW 3965 hydrochloride	sc-224011	GW 3965 hydrochloride is a non-steroidal agonist of liver X receptor (LXR), which specifically induces hLXR&alpha and hLXR&beta. CAS # 405911-17-3
Thyroid Hormone Receptor Antagonist, 1-850	sc-222357	Thyroid Hormone Receptor Antagonist, 1-850 is a cell-permeable hydrazinyl-carboxamide compound which acts as a selective and high-affinity Thyroid Receptor (thyroid hormone receptor) antagonist.