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Enzyme Activators

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Metastin (45-54)sc-221883Metastin (45-54) is a decapeptide with C-terminally amidated LRF-motif which acts as a potent and selective agonist of GPR54 (AXOR12 and hOT7T175, a novel human G-protein-coupled receptors). CAS # 374675-21-5

α-Amyloid Precursor Protein Modulatorsc-204424α-Amyloid Precursor Protein Modulator is an activator of PKCα. CAS # 497259-23-1

D-Cycloserinesc-221470D-Cycloserine is a partial agonist of NMDA receptors at the glycine site and inhibitor of bacterial cell wall biosynthesis. CAS # 68-41-7

Sp-Adenosine 3',5'-cyclic monophosphorothioate triethylammonium salt hydratesc-258176Sp-Diastereomer of adenosine 3',5'-cyclic monophosphorothioate is a potent, membrane-permeable activator of PKA (cAMP dependent protein kinase I and II). CAS # 93602-66-5 (anhydrous)

Dexmedetomidine hydrochloridesc-205290Medetomide’s active isomer which is a potent, highly selective α2-adrenoceptor agonist. CAS # 145108-58-3

Guanosine-3′,5′-cyclic Monophosphate, 8-(2-Aminophenylthio)-Sodium Saltsc-203335Guanosine-3',5'-cyclic Monophosphate, 8-(2-Aminophenylthio)-Sodium Salt is an isozyme-selective activator of cGKIα( cGMP-dependent protein kinase 1α ). CAS # 144509-87-5

Lactosyl Ceramide, Bovinesc-204051Lactosyl Ceramide, Bovine stimulates Ras-GTP loading, Raf and MEK kinases, p44 MAP kinase in human aortic smooth muscle cells. CAS # 4682-48-8

Trimebutine basesc-204927Trimebutine base is an opioid receptor agonist. Trimebutine base is an activator of KOR, DOR and MOR. CAS # 39133-31-8

NOR-3sc-202738NOR-3 is a cell-permeable, non-thiol, nitric oxide donor that can spontaneously release NO in a rate controlled manner (half-life (t½) in PBS, pH 7.4 is 30 minutes at 37°C) generating biologically inactive by-products. CAS # 163180-49-2

Vinyl-L-NIO (hydrochloride)sc-205541A potent, selective inhibitor of nNOS; in the presence of NADPH and O2 it irreversibly inactivates nNOS. CAS # 728944-69-2

Lipoprotein Lipase Activatorsc-204059Lipoprotein Lipase Activator is a cell-permeable benzylphosphonate derivative that selectively induces lipoprotein lipase (LPL) mRNA and protein levels, but does not exhibit PPARα or PPARγ agonistic activities. CAS # 133208-93-2

PS 48sc-361297PS 48 has been shown to be a phosphoinositide-dependent protein kinase-1 (PDK1) activator. CAS # 1180676-32-7

(+)-Fluprostenolsc-205326Is the metabolically stable analog of PGF2α. Is a potent FP prostanoid receptor agonist. The optically active enantiomer of fluprostenol. Expected potency is 2x that of (+/−)-fluprostenol. PGF2α binding to human and rat FP receptors is. An effective inhibitor of rat adipose precursor differentiation in primary cultures. CAS # 54276-17-4

U 92016Asc-204363Selective 5-HT1A receptor agonist that displays high intrinsic activity (Ki values are 0.4, 7.7 and 36 nM for 5-HT1A, 5-HT1D and D2 receptors respectively and > 1000 nM for 5-HT2, D1, α1 and α2 receptors). Produces hypotension, hypothermia and 5-HT behavioral syndrome following p.o. administration. CAS # 149654-41-1

Estropipatesc-203946Estropipate is an Estrogen Receptor (ER) agonist. Estropipate can also inhibit organic anion transporting polypeptide 1B1 (OATP1B1) (IC50= 70 nM). CAS # 7280-37-7

PI-3,4,5-P3, 7NH4, PIP3, Dipalmitoyl- sc-222174PI-3,4,5-P3, 7NH4, PIP3, Dipalmitoyl- activates Ca2+-insensitive PKCδ, PKCε, and PKCη. Binds to the general receptor for phosphoinositide-1 (GRP1) protein through a plekstrin homology (PH) domain.