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PRODUCT NAMECATALOG #DESCRIPTIONCITATIONSRANKING
2',3'-Dideoxyadenosine-5'-triphosphate Lithium Saltsc-288569Shown to be an inhibitor of chain elongation usually catalyzed by DNA polymerase I CAS # 93939-70-9

Amsacrine hydrochloridesc-214540Inhibits DNA topoisomerase II. CAS # 54301-15-4

Clinafloxacin Hydrochloridesc-202998Clinafloxacin hydrochloride is an antimicrobial fluoroquinolone which inhibits topoisomerase IV. CAS # 105956-99-8

Cytosine β-D-arabinofuranoside hydrochloridesc-221454An anti-leukemic agent which binds to topoisomerase I resulting in DNA fragmentation and inhibition of replication. In addition this compound does not have any effects on RNA synthesis. CAS # 69-74-9

Merbaronesc-204076A cell-permeable anticancer drug that inhibits the catalytic activity of topoisomerase II (topo II) while not damaging DNA or stabilizing DNA-topo II cleavable complexes (IC50 = 20 µM for purified mammalian topo II versus IC50 ~ 200 µM for topo I). Induces apoptosis in human leukemic CEM cells through a caspase-3-like protease-dependent mechanism. CAS # 97534-21-9

Podophyllotoxinsc-204853Podophyllotoxin is a potent inhibitor of microtubule assembly that binds at the colchicine site of tubulin. CAS # 518-28-5

Sobuzoxanesc-215862An inhibitor of DNA topoisomerase II which induces apoptosis. CAS # 98631-95-9

Mitoxantrone Dihydrochloridesc-203136Mitoxantrone Dihydrochloride is an antiviral, antibacterial, antiprotozoal, immunomodulating, Topo II inhibitor, and antineoplastic cytostatic anthraquinone derivative. CAS # 70476-82-3