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Caspase Activators

We now offer a broad range of Caspase Activators. Caspase family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Caspase Activators offered by Santa Cruz activate Caspase and, in some cases, other apoptosis and tumor related proteins. View detailed Caspase Activator specifications, including Caspase Activator CAS number, molecular weight, molecular formula and chemical structure, by linking to the specific product blocks.

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For functional analysis of Caspase Activators, see our complete listing of Caspase Antibodies.


PRODUCT NAMECATALOG #DESCRIPTIONCITATIONSRANKING
25-Hydroxycholesterolsc-21409125-Hydroxycholesterol suppresses the cleavage of sterol regulatory element binding proteins (SREBPs). It also induces apoptosis through down-regulation of Bcl-2 expression and activation of caspases. CAS # 2140-46-7

Apoptosis Activator 2sc-202956Apoptosis Activator 2 activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells. CAS # 79183-19-0

ABT-869sc-359037ABT-869 is an ATP-competitive, multi-targeted inhibitor effective against VEGF (Flk/Flt) and PDGFR families. CAS # 796967-16-3

Azaspiracid-1sc-202482Azaspiracid-1 is an activator of JNK (c-Jun-N-terminal kinase)and caspases. It is also a cellular growth inhibitor and inducer of cytoskeletal alterations. CAS # 214899-21-5

Betulinic Acidsc-200132Betulinic Acid is a cytotoxic agent that upregulates apoptotic proteins and affects mitochondrial membrane permeability. Also acts as a potent inhibitor of Hh/Gli signaling pathway. CAS # 472-15-1

Imiquimodsc-200385Imiquimod is a TLR7 (toll-like receptor 7) activator. Inhibits angiogenesis, induces apoptosis and modifies the immune response. Suggested to activate caspase-3 and NFκB. CAS # 99011-02-6

Borrelidinsc-200379Borrelidin is an anti-angiogenic and anti-microbial compound that disrupts capillary tube formation by activating caspase-3 and caspase-8. It also inhibits ThrRS and HUVEC proliferation. CAS # 7184-60-3

Lonidaminesc-203115Lonidamine has been reported to inhibit angiogenic-related endothelial cell functions, block CFTR Cl- channels in vitro, and to cause a decrease in proliferation, migration, and morphogenesis of cells. CAS # 50264-69-2

CIL-102sc-214722CIL-102 is a semisynthetic alkaloid derivative, which inhibits cell growth in a wide variety of cancer cell lines in a dose dependent manner. CAS # 479077-76-4

Cisplatinsc-200896Cisplatin is a potent platinum-based antineoplastic agents that is believed to form inter- and intrastrand DNA adducts. It has also been shown to induce apoptosis through caspase-3 activation and XIAP expression. CAS # 15663-27-1

12
Dihydrolipoic acidsc-207581Dihydrolipoic acid induces apoptosis in mouse embryonic stem cells (ESC-B5) at 50-100 μM concentrations. In addition, it increases reactive oxygen species (ROS), cytoplasmic free calcium and nitric oxide (NO) levels. CAS # 462-20-4

Brefeldin A (BFA)sc-200861Brefeldin A (BFA) blocks the GTP-dependent interaction of ARF with the Golgi membrane and inhibits secretion from the Golgi apparatus. It can induce apoptosis by activating caspase-3 and inhibit cell growth by targeting the cell cycle. CAS # 20350-15-6

1
Fumonisin B1sc-201395Fumonisin B1 is a fungal metabolite that inhibits serine/threonine phosphatases. It also inhibits LASS (ceramide synthase), induces apoptosis. CAS # 116355-83-0

1
Garcinolsc-200891Garcinol is a potent inhibitor of p300 and PCAF histone acetyltransferases. It promotes apoptosis through caspase-3 activation and predominantly down-regulates global gene expression in HeLa cells. CAS # 78824-30-3

Kinetin ribosidesc-221789Kinetin riboside i san anti-proliferative agent which is found to induce apoptosis in certain cell lines. It has been shown to upregulate CDKN1A, cause depletion of ATP, and cause a cell cycle arrest at the G2/M phase. CAS # 4338-47-0

DuP-697sc-200680DuP-697, an anti-inflammatory agent, is an inhibitor of Cox-1 and Cox-2 with 50 fold more selectivity for Cox-2 than for Cox-1. It also suppresses cell growth and induces apoptosis by cell-cycle arrest and caspase-8 activation. CAS # 88149-94-4

Levamisole Hydrochloridesc-205730Levamisole Hydrochloride is an immunomodulatory agent which selectively induces apoptosis in human micro-and macro vascular endothelial cells. CAS # 16595-80-5

Mitomycin Csc-3514Mitomycin C is a DNA crosslinking and damaging agent that inhibits DNA synthesis and induces apoptosis in a variety of cells via a p53-dependent pathway and activation of caspase-3, caspase-8, and caspase-9. CAS # 50-07-7

9
Bcl-2 Inhibitor II, YC137sc-221287Bcl-2 Inhibitor II, YC137 is a cell-permeable selective apoptosis inducer of Bcl-2-overexpressing cells and disrupts Bcl-2 interaction with Bid BH3. CAS # 810659-53-1

PETCMsc-202279PETCM is an activator of caspase-3 and a stimulator of apoptosome formation in HeLa cell cytosols. In addition, studies suggest that PETCM can reverse the inhibitory effects of putative HLA-DR-associated proteins (PHAP) on caspase-3 activation. CAS # 10129-56-3

Bcl-2 Inhibitor III, EM20-25sc-221288Bcl-2 Inhibitor III, EM20-25 is a cell-permeable Bcl-2 inhibitor that disrupts interactions with Bax. It has also shown to activate caspase-9 and induce PTP opening. CAS # 141266-44-6

Prodigiosinsc-202298Prodigiosin is a water insoluble, potent proapoptotic compound that belongs to a family of Prodigions isolated from gram-negative bacteria. It is also described as a red-pigmented antibiotic produced by Serratia marcescens strains. CAS # 82-89-3

1
Proscillaridin Asc-202775Proscillaridin A is a cardiac glycoside which functions as a specific Na+/K+-ATPase inhibitor. At high concentrations Proscillaridin A can increase intracellular Ca2+ concentration, activate caspase-3 and induce apoptosis in human fibroblasts. CAS # 466-06-8

RETRA hydrochloridesc-204234RETRA hydrochloride inhibits tumor cell growth in a mutant p53- and p73-dependent manner. It also transcriptionally activates expression of p53-responsive genes and induces activation of effector caspase-3 and caspase-7. CAS # 1036069-26-7

Gambogic Acid sc-200137Gambogic Acid induces apoptosis without affecting the cell cycle and inhibits Bcl-2 family proteins. Gambogic Acid targets transferrin receptors and activates caspases. CAS # 2752-65-0

Trimidoxsc-222372Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-60 cells, inducing apoptosis via activation of caspases without altering the cell cycle distribution. CAS # 95933-74-7

HA14-1sc-205911HA14-1 is a small, cell-permeable blocker of Bcl-2 action via surface pocket binding. Shown to induce apoptosis and disrupt Bax/Bcl-2 interaction. CAS # 65673-63-4

Valinomycinsc-200991Valinomycin is a dodecadepsipeptide and potassium ionophore shown to induce cell death. It has been reported to promote hemolysis in HK erythrocytes and cell death in CHO cells. CAS # 2001-95-8

Zearalenonesc-204943Zearalenone, is a phytoestrogenic mycotoxin usually produced by Fusarium species. It is also shown to be an anti-proliferative agent that causes mitochondrial release of Cytochrome c and production of ROS. CAS # 17924-92-4

SC 560sc-202805SC 560 is reported to be a Cox-1 and Cox-2 inhibitor, and is highly selective for Cox-1 over Cox-2. It also activates caspase-3 and caspase-7 which results in apoptosis of cells. CAS # 188817-13-2

NSC 95397sc-203654NSC 95397 is a selective and effective dual-specificity, quinone-based phosphatase inhibitor. The compound has been reported to inhibit Cdc25A, B and C. CAS # 93718-83-3

3
Sodium Phenylbutyratesc-200652Sodium phenylbutyrate is an HDAC (histone deacetylase) inhibitor. It suppress ER-mediated apoptosis by initiating factor 2α phosphorylation, caspase-12 activation, and CCAAT/enhancer-binding protein homologous protein induction. CAS # 1716-12-7

Alsterpaullonesc-202453Alsterpaullone is a potent ATP-competitive and cell cycle cyclin-dependent kinase inhibitor, reported to be the most active paullone. CAS # 237430-03-4

1
MT-21sc-221959A cell-permeable antitumor agent that induces apoptosis (~40 µM) by directly releasing cytochrome c from mitochondria in human promyelocytic leukemia HL-60 cells. Does not affect mitochondrial transmembrane potential (ΔΨm) in any significant manner. Selectively induces neurite outgrowth in cultured SH-SY5Y, and causes apoptosis in PC12 cells.

Embelinsc-201555Embelin has been shown to be an antinociceptive and antiinflammatory agent with antioxidative capabilities. This compound has also been reported to induce apoptosis. CAS # 550-24-3

1
Cdk2 Inhibitor IV, NU6140sc-202531Cdk2 Inhibitor IV, NU6140 is a highly cell-permeable purine compound that displays anticancer properties and acts as a selective and ATP-competitive inhibitor of Cdks. CAS # 444723-13-1

K 858sc-300856K 858 is an ATP-uncompetitive mitotic kinesin Eg5 inhibitor, which does not effect microtubule dynamics. It causes mitotic arrest, cell growth inhibition, and activates caspase-3. CAS # 72926-24-0