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Antitumor

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PRODUCT NAMECATALOG #DESCRIPTIONCITATIONSRANKING
Arctigeninsc-202957Arctigenin is a dibenzyl butyrolactone lignan agent with anti-inflammatory and antioxidant properties. Studies describe Arctigenin to potently block TNF- α production and NO secretion. Arctigenin also inhibitos HIV-1 integrase. Furthermore, this compound acts as an inhibitor of IκB phosphorylation. CAS # 7770-78-7

2-Demethylthiocolchicinesc-213789Exhibits anti-tumor activity. CAS # 87424-26-8

2-n-Heptylfuransc-204618Inhibitor of BP-induced lung and fore-stomach tumorigenesis in mice. CAS # 3777-71-7

2-O-Methyl PAFsc-205575Has antineoplastic activity1,2,3, partial PAF agonist and desensitizes neutrophil PAF receptors4.

2-Phthalimidino-glutaric acidsc-220763A stable analog of thalidomide with increased antitumor (antimetastatic) potency

Betulinic Acidsc-200132Betulinic Acid is a cytotoxic agent that upregulates apoptotic proteins and affects mitochondrial membrane permeability. Also acts as a potent inhibitor of Hh/Gli signaling pathway. CAS # 472-15-1

2'-Acetyltaxolsc-205989Taxol analog which displays no significant microtubule polymerization activity in vitro. CAS # 92950-40-8

3-O-Acetyl-betulinic acidsc-202017Shows cytotoxic activity on human cancer cell lines. CAS # 10376-50-8

3-O-Acetyl-β-boswellic acidsc-2028853-O-Acetyl-β-boswellic acid is a potent non-redox, non-competitive 5-LO (5-lipoxygenase) and topoisomerase I and II inhibitor. CAS # 5968-70-7

Lomustinesc-202697Lomustine possesses antitumor activity along with inhibitive activity towards glutathione reductase, lipoamide dehydrogenase and trypanothione reductase. It also activates p53 expression in A2870 cells. CAS # 13010-47-4

Bezafibratesc-204650Bezafibrate is a peroxisome proliferator and hypolipidaemic agent that is a derivative of clofibrate. Shown to be effective in preventing mammary tumors induced by radiation together with DES, possibly by reducing prolactin and triglyceride concentrations. CAS # 41859-67-0

(3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acidsc-206740Intermediary obtained in the synthesis of members of the Epothilone family, polyketide natural products that inhibit cancer cells via a mechanism similar to Paclitaxel. Also found to be effective against Paclitaxel-resistant tumors. Currently in Phase I of clinical testing. CAS # 193146-26-8

Ridaforolimussc-212783Ridaforolimus (Deforolimus, AP23573, MK-8669) is a selective FRAP (mTOR) inhibitor (IC50 of 0.2 nM). CAS # 572924-54-0

NSC 146109 hydrochloridesc-203652NSC 146109 hydrochloride is a cell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription. CAS # 59474-01-0

Temsirolimussc-220202Temsirolimus is a potent inhibitor of FRAP (mTOR) kinase activity with IC50 of 1.76 μM in the absence of FKBP12, similar to that of rapamycin (IC50 of 1.74 μM). CAS # 162635-04-3

4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazolesc-206783Intermediary obtained in the synthesis of members of the Epothilone family, polyketide natural products that inhibit cancer cells via a mechanism similar to Paclitaxel. Also found to be effective against Paclitaxel-resistant tumors. Currently in Phase I of clinical testing. CAS # 308357-81-5

4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-undeca-1,5-dienyl]-2-methyl-1,3-thiazolesc-206784Intermediary obtained in the synthesis of members of the Epothilone family, polyketide natural products that inhibit cancer cells via a mechanism similar to Paclitaxel. Also found to be effective against Paclitaxel-resistant tumors. Epothilone D is currently in Phase I of clinical testing. CAS # 210690-85-0

Stat3 Inhibitor III, WP1066sc-203282Stat3 inhibitor III, WP1066 is a cell permeable inhibitor of STAT3, JAK2 protein tyrosine kinase and tumor cell growth. Also suggested to be an activator of Bax. CAS # 857064-38-1

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4-Desacetyl Vinblastine Methosulfatesc-210025An anti-tumor agent used in the treatment of prostate cancer.

4-Desacetyl Vincristine Methosulfatesc-206872An antitumor agent used against human colon carcinoma. CAS # 3704-01-6

(4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[tert-butyl(dimethyl)silyl]oxy}-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]oxocyclohexadec-13-ene-2,6-dionesc-206960Intermediary obtained in the synthesis of members of the Epothilone family, polyketide natural products that inhibit cancer cells via a mechanism similar to Paclitaxel. Also found to be effective against Paclitaxel-resistant tumors. CAS # 189453-35-8

Levamisole Hydrochloridesc-205730Levamisole Hydrochloride is an immunomodulatory agent which selectively induces apoptosis in human micro-and macro vascular endothelial cells. CAS # 16595-80-5

5-Aminouridine, Hydrochloridesc-206991Inhibits the growth of bacteria, fungi, viruses, protozoa, and tumors. CAS # 116154-74-6

Epirubicinsc-279016Epirubicin is a cell-permeable antitumor antibiotic. A stereoisomer of Doxorubicin that exhibits reduced cardiotoxicity. Epirubicin’s antitumor actions are mediated by targeting and inhibiting Topo II (topoisomerase II). CAS # 56420-45-2

6-(gamma,gamma-Dimethylallylamino)purine ribosidesc-291159This product is a cytokinin, natural component of certain tRNA's, possessing antitumor and immunosuppressant activity. CAS # 33156-15-9

6-Mercaptopurine Monohydratesc-205585 An anti-inflammatory agent that has antitumor activity.An antimetabolite of hypoxanthine. It is also an antitumor agent and induces apoptosis. CAS # 6112-76-1

7-epi-Taxolsc-202894The compound 7-epi-Taxol has been isolated from Taxus brevifolia. It is an antineoplastic currently being used in cancer research. CAS # 105454-04-4

8-Desacetyl-8-carboxy Daunorubicin Hydrochloridesc-210677Antitumor drug. Doxorubicin analog. CAS # 58199-96-5

RETRA hydrochloridesc-204234RETRA hydrochloride inhibits tumor cell growth in a mutant p53- and p73-dependent manner. It also transcriptionally activates expression of p53-responsive genes and induces activation of effector caspase-3 and caspase-7. CAS # 1036069-26-7

17a-Hydroxyprogesteronesc-204614An antiestrogen used to treat advanced endometrial cancer and breast cancer. CAS # 68-96-2

17-(Allylamino-d5) Geldanamycinsc-213619A potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It displays antitumor effects and induces apoptosis. 17-AAG inhibits the activity of oncogenic proteins such as Ki-ras, N-ras, c-Akt, and p185erB2. CAS # 75747-14-7 (unlabeled)

(+)-Irinotecansc-269253(+)-Irinotecan is an isomer of the Topo I inhibitor Irinotecan sc-202186). CAS # 97682-44-5

9-Hydroxyellipticine, Hydrochloridesc-2039409-Hydroxyellipticine, Hydrochloride is a cell-permeable antitumor alkaloid that acts as an inhibitor of topoisomerase II and mutant p53 protein phosphorylation. CAS # 52238-35-4

10-Deacetylbaccatin-IIIsc-204607Intermediate for taxol analog preparations. Taxols have exhibit antitumor agents. Several of these taxols can be synthesized from 10- Deacetylbaccatin-III. CAS # 32981-86-5

18 β-Glycyrrhetinic Acidsc-205573The aglycone of the triterpenoid Glyccyrrhizic acid. Has potent antitumor promoting activity. CAS # 471-53-4

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21-Hydroxyoligomycin Asc-202013An oligomycin antibiotic co-isolated with nemadectins. Demonstrates nematocidal, antifungal, and antitumor effects. CAS # 102042-09-1

27-Hydroxycholesterolsc-358756An oxysterol secreted from macrophages shown to pass the blood-brain barrier. Also reported to be a cholesterol oxidation metabolite with apoptotic properties. CAS # 20380-11-4

a, b-Dihydroresveratrolsc-204634Natural phytoestrogen found in red wine and a variety of other plants. Contains potential anti-cancer properties. CAS # 58436-28-5

alpha-Cembrenediolsc-360746An antitumor agent found in cigarette smoke condensate. CAS # 57605-80-8

Ancitabine hydrochloridesc-217650An antineoplastic. CAS # 10212-25-6

Aristoforinsc-202958Stable and water-soluble derivative of hyperforin inducing apoptosis. Antitumor agent. Inhibits sirtuins. CAS # 849215-53-8

β-Cryptoxanthinsc-300397A carotenoid pigment with antioxidant properties, which is reported to inhibit carcinogencity in vitro. CAS # 472-70-8

Autophagy Inducer, STF-62247sc-203831A cell-permeable autophagy inducer that selectively induces non-apoptotic cell death in VHL- (von Hippel-Lindau) deficient, but not VHL-expressing, renal carcinoma cells both in vitro (IC50 = 0.625 and 16 µM in RCC4 and RCC4/VHL killing, respectively) and in mice in vivo (>90% 786-O tumor growth suppression; 8 mg/kg via daily i.p.). Although STF-62247 induces autophagy regardless of cellular VHL-expression level, STF-62247 treatment is shown to result in more enhanced/acidified autolysomes formation in VHL-deficient cells, implicating an important role of VHL in maintaining normal vesicular trafficking between ER, TNG, and lysosomes. CAS # 315702-99-9

SN 38sc-203697SN 38 inhibits DNA and RNA synthesis (IC50 values are 0.077 and 1.3 µM respectively) but does not affect protein synthesis. Displays potent antitumor activity against a range of human tumor cell lines and is an inhibitor of Topo II. CAS # 86639-52-3

(-)-Arctiinsc-202064(-)-Arctiin is a lignan derivative with antitumor activities acting as a potent inhibitor of HIV-I integrase and DNA topoisomerase II. (-)-Arctiin also down-regulates anti-apoptotic protein Bcl-XL. CAS # 20362-31-6

β-Cembrenediolsc-204635Compound found in cigarette smoke condensate shown to inhibit tumor promotion by tetradecanoylphorbol acetate by inhibiting the early antigen of the Epstein-Bar virus. Degradation products are responsible for tobacco flavors. CAS # 57605-81-9

Benzyl selenocyanatesc-204642A versatile synthetic organoselenium chemopreventive agent. Found to be effective in several animal tumor model systems. CAS # 4671-93-6

Bergenin monohydratesc-205601An isocoumarin isolated from various medicinal plants. Shows mild anti-HIV activity, antihepatotoxic activity and antiulcer activity. CAS # 477-90-7

Berteroinsc-204646Protects against metastaticity as well as tumor cell growth. CAS # 4430-42-6

BEPP monohydrochloridesc-214594BEPP monohydrochloride is a double-strand RNA-dependent protein kinase (PKR) activator; a ubiquitously expressed serine threonine kinase, inducible by interferon. CAS # 455311-98-5

Bropiriminesc-362719 CAS # 56741-95-8

Bryostatin 2sc-202086A macrocyclic lactone with anti-tumor properties, activator of PKC and inducer of cell differentiation of recombinant B cell stimulatory factor-1. CAS # 87745-28-6

Busulfan-d8sc-217804Antineoplastic, alkylating agent with antileukemic activity. CAS # 116653-28-2

Calcium Folinate, Pentahydratesc-204665When administered after methotrexate, this supplies cells with tetrahydrofolate and diminishes methotrexate toxicity without abolishing antitumor effect. CAS # 6035-45-6

Capecitabinesc-205618Prodrug that inhibits DNA synthesis and slows growth of tumor tissue upon enzymatic conversion to 5-fluorouracil in the tumor. The chemotherapeutic agent is used in the treatment of metastatic breast and colorectal cancers. CAS # 154361-50-9

Bicalutamidesc-202976Bicalutamide is a nonsteroidal androgen receptor inhibitor. Bicalutamide is induces cell death by a pathway that is independent of changes in mitochondrial membrane potential and Bcl-2 action. CAS # 90357-06-5

Capsanthinsc-204667A natural carotenoid isolated from red paprika. It has chemopreventive and anti-tumor activity. CAS # 465-42-9

Carboplatinsc-202093A second generation potent platinum-based anti-neoplastic agent tha binds to DNA culminating in apoptosis; displays potent antitumor activity with lower nephrotoxicity than Cisplatin (sc-200896). CAS # 41575-94-4

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Carmustinesc-204671A member of the antineoplastic nitrosourea compounds, and inhibitor of glutathione reductase, trypanothione reductase, and lipoamide dehydrogenase CAS # 154-93-8

Catechinsc-205624A natural flavonoid that has chemopreventive and antitumor properties. CAS # 154-23-4

Catharanthine basesc-204674One of the many alkaloids present in Catharanthus roseus. Can be used as a starting material for the synthesis of the anti-tumor drugs vinblastine and vincristine. It is less active as an inhibitor of tubulin self-assembly into microtubules than the latter two compounds. CAS # 2468-21-5

L-Sulforaphanesc-203099An inducer of apoptosis, phase II detoxification enzyme, as well as xenobiotic enzymes. Also shown to inhibit strains of Helicobacter pylori. CAS # 142825-10-3

Catharanthine tartratesc-202524Starting material for the synthesis of the antitumor drugs vinblastine and vincristine. It is less active as an inhibitor of tubulin self-assembly into microtubules than the latter two compounds. CAS # 4168-17-6

CCT007093sc-214673An effective PPM1D inhibitor that selectively reduces viability of human tumour cell lines. CAS # 176957-55-4

CDC25 Phosphatase Inhibitor I, BN82002sc-311302A cell-permeable ortho-hydroxybenzylamino compound that have been reported to display antitumor properties.

cDPCPsc-214675A tumor cell permeable, potent platinum-based antineoplastic agent; a cationic monofunctional platinum(II) complex with unique chemical and biological properties. CAS # 106343-54-8

Cephalomanninesc-205626May have an antineoplastic effect on tumors found in mice. Was isolated from Taxus yunnanensis. CAS # 71610-00-9

Chalconesc-204681An open chain flavonoid that inhibits lung and forestomach carcinogenesis. CAS # 614-47-1

CHS-828sc-364106 CAS # 200484-11-3

Cyclosporin Dsc-204702Weak immunosuppressor but potent inhibitor of tumor promoting phorbol ester TPA/PMA in vivo. Also, potent inhibitor of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro. CAS # 63775-96-2

D-64131sc-203908D-64131 is a novel inhibitor of tubulin polymerization that competitively binds with [(3)H]colchicine to αβ-tubulin. D-64131 is cytotoxic and inhibits tumor cell proliferation in vitro. CAS # 74588-78-6

Desulfo-glucoraphaninsc-204713A glucoraphanin analogue. CAS # 287966-62-5

Diallyl trisulfidesc-205645Sulfer-based compound obtained from garlic and onion that is an inhibitor of chemically induced tumorigenesis. CAS # 2050-87-5

Diastovaricin Isc-364108 CAS # 102281-52-7

Dibenzoylmethanesc-204719A minor constituent of licorice and found to inhibit mammary tumorigenesis, and lymphomas and leukemias in mice. CAS # 120-46-7

Dipropyl disulfidesc-204730BP-induced inhibitor forestomach cancer in mice. CAS # 629-19-6

Enniatin Asc-202148An ionophore that is a major analogue of the enniatin complex. CAS # 2503-13-1

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Diphenhydramine hydrochloridesc-204729Diphenhydramine hydrochloride blocks the effect of histamine at H1 receptor sites, has been shown to have inhibitive tumor promotion properties, and decreases peripheral nociceptors sensitization. CAS # 147-24-0

Enniatin A1sc-202149Enniatins are depsipeptides shown to act as ionophores. Their effects on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumor action have received more focus. CAS # 4530-21-6

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Enniatin B1sc-202151Enniatins are depsipeptides shown to act as ionophores. Their effects on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumor action have received more focus. CAS # 19914-20-6

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Enniatin complexsc-202152Enniatins are a complex of depsipeptides. Typically, the complex contains 4 major components: A, A1, B and B1 together with minor amounts of enniatin C, D, E and F. The enniatins act as ionophores. CAS # 11113-62-5

Enocitabinesc-205310Anti-tumor agent potentially for anti-leukemia treatment.An antineoplastic. A derivative of Cytarabine. CAS # 55726-47-1

Estronesc-205683Estradiol metabolite found to reduce colon tumorigenesis in mice, independent of ERalpha. Also found to inhibit BCRP-mediated drug efflux and overcome drug resistance. CAS # 53-16-7

exo-7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic anhydridesc-280719 CAS # 29745-04-8

Fasciculatinsc-202607A furanosesterterpene secondary marine metabolite isolated from marine sponges with moderate cytotoxicity. CAS # 37905-12-7

Flavanonesc-205693Natural flavonoid from plants. Found to inhibit tumor cells in culture; its oxime derivative induces apoptosis. CAS # 487-26-3

Gimeracilsc-207714An antitumor agent and a potent inhibitor of dihydropyrimidine dehydrogenase (DPD). CAS # 103766-25-2

Ginsenoside Rb1sc-204765May have properties that inhibit or prevent the growth of tumors. CAS # 41753-43-9

Ginsenoside Rcsc-203970May have properties that inhibit or prevent tumors growth. CAS # 11021-14-0

Ginsenoside Rdsc-205706May have properties that inhibit or prevent the growth of tumors. CAS # 52705-93-8

Ginsenoside Resc-205707May have properties that inhibit or prevent the growth of tumors. CAS # 52286-59-6

Ginsenoside Rg1sc-205708Molecular compound that may have inhibitive properties for the prevention of growth of tumors. CAS # 22427-39-0

Ginsenoside Rg2sc-205709May have properties that inhibit or prevent the growth of tumors. CAS # 52286-74-5

D-saccharic acid calcium salt tetrahydratesc-205336Nontoxic, natural compound. Derivative 1,4-GL increases detoxification of carcinogens and tumor promoters/progressors by inhibiting beta-glucuronidase and preventing hydrolysis of their glucuronides. When fed during initiation, promotion, or both phases of chemically induced rat mammary carcinogenesis, has been found to reduce tumor incidence and multiplicity. CAS # 5793-89-5

Harringtoninsc-204771An alkaloid isolated from Cephalotaxus harringtonia, and an antitumor agent. CAS # 26833-85-2

Herbimycin Csc-202175Possesses antitumor activity and has been shown to convert RSV- infected rat kidney cells into normal cells. CAS # 91700-92-4

Hydroquinonesc-204773Topical hydroquinone is used in the treatment of an array of skin conditions and found to reduce the viable cell number of oral tumor cell. CAS # 123-31-9

Iodoacetic acidsc-215183Reagent for the modification of cysteine residues in proteins. CAS # 64-69-7

Kahweol palmitatesc-204779Naturally occurring ester present in green coffee beans that inhibits mammary tumor formation. CAS # 81760-45-4

Kibdelone Asc-362757Kibdelone A is potent antitumor metabolite isolated from Kibdelosporangium sp.. Structurally, kibdelone A is related to lysolipin and albofungin, however no comparative investigation of this class has been reported. The mode of action and pharmacology of the kibdelones has received little attention. CAS # 934464-77-4

Kibdelone Bsc-362758Kibdelone B is a minor analogue of a potent antitumor complex isolated from Kibdelosporangium sp.. Structurally, kibdelone B is related to lysolipin and albofungin, however no comparative investigation of this class has been reported. The mode of action and pharmacology of the kibdelones has received little attention. CAS # 934464-78-5

Kibdelone Csc-362759Kibdelone C is the major analogue of a potent antitumor complex isolated from Kibdelosporangium sp.. Structurally, kibdelone C is related to lysolipin and albofungin, however no comparative investigation of this class has been reported. The mode of action and pharmacology of the kibdelones has received little attention. CAS # 934464-79-6

Kuanoniamine Csc-202682Cytotoxic. Inhibits proliferation of several cell lines. Binds to adenosine receptor subtypes A1 and A2A. CAS # 133401-11-3

L-Sulforaphenesc-202690Shows antitumor activity. CAS # 592-95-0

Lipoprotein Lipase Activatorsc-204059Lipoprotein Lipase Activator is a cell-permeable benzylphosphonate derivative that selectively induces lipoprotein lipase (LPL) mRNA and protein levels, but does not exhibit PPARα or PPARγ agonistic activities. CAS # 133208-93-2

Luteoreticulinsc-202213Rare nitrophenyl pyranone closely related to aureothin, neoaureothin and Antibiotics SNF4435C and D. These metabolites are potent antitumor and immunosuppressive agents. CAS # 22388-89-2

m-Iodobenzylguanidine hemisulfate saltsc-200865m-Imodobenzylguanidine is a norephinephrine analog anti-tumor agent and radiopharmaceutical in its radioiodinated form. CAS # 80663-95-2

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Medroxyprogesterone 17-Acetatesc-205744An angiostatic steroid, found to inhibit tumor growth, collagenolysis, vascularization, and plasmin generation. CAS # 71-58-9

L-Theaninesc-204787L-Theanine is an analog of glutamine and one of the components of green tea. L-Theanine binds to AMPA, Kainate, NMDA, and group I mGlu receptors. CAS # 3081-61-6

Mitotanesc-205754A dichlorodiphenyldichloroethane compound with antiproliferative effects. Demonstrates efficacy against adrenocortical carcinoma. CAS # 53-19-0

Letrozolesc-204791Letrozole is known to inhibit estradiol production in vitro in hamster ovarian tissue that is LH-stimulated. It has not been shown to have a significant effect on progesterone production up to 350 M. CAS # 112809-51-5

MT-21sc-221959A cell-permeable antitumor agent that induces apoptosis (~40 µM) by directly releasing cytochrome c from mitochondria in human promyelocytic leukemia HL-60 cells. Does not affect mitochondrial transmembrane potential (ΔΨm) in any significant manner. Selectively induces neurite outgrowth in cultured SH-SY5Y, and causes apoptosis in PC12 cells.

N-Desformyl-4-desacetyl Vincristinesc-212180A derivative of an antitumor alkaloid. CAS # 55324-83-9

Nedaplatinsc-202238A platinum complex that has potent antineoplatic activity. CAS # 95734-82-0

Nimustine hydrochloridesc-202732DNA alkylator and cross-linker. Anticancer agent used to treat malignant glioma. Cardiovascular teratogenicity was studied in rat fetuses. CAS # 55661-38-6

NSC 721648sc-203165A high affinity AhR ligand and CYP1A1 inducer with antitumor activity. CAS # 872726-44-8

Odorinesc-203169Cancer chemopreventive agent. Inhibits both the initiation and promotion stages of two-stage skin carcinogenesis. CAS # 72755-20-5

Odorinolsc-203170Cancer chemopreventive agent. Inhibits both the initiation and promotion stages of two-stage skin carcinogenesis. CAS # 72755-22-7

Oltiprazsc-205777An anti-neoplastic agent that has been found to be effective against several chemically induced tumor models, which has been attributed to the induction of phase II detoxifying enzymes. CAS # 64224-21-1

Megestrol Acetatesc-205382Progesterone derivative with antineoplastic properties that is an orally active progestogen used in advanced breast cancer treatment. CAS # 595-33-5

Oxymatrinesc-279937A compound from Sophora japonica, which has many biologically functions such as the inhibition of IL-6 and IL-1β mRNA expression. CAS # 16837-52-8

Oxaliplatinsc-202270A second generation potent platinum-based anti-neoplastic agent believed to form inter- and intrastrand DNA adducts culminating in apoptosis, and has shown efficacy in cell lines with Cisplatin (sc-200896) resistance. CAS # 61825-94-3

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Phenethyl isothiocyanatesc-205801NNK-induced lung tumorigenesis inhibitor CAS # 2257-09-2

Phenyl isothiocyanatesc-204842Inhibitor of NNK-induced lung tumorigenesis. CAS # 103-72-0

Phenylhexyl isothiocyanatesc-204844Chemopreventive agent in mouse lung and found to enhance colon and esophageal tumorigenesis in the rat. CAS # 133920-06-6

Physcionsc-205805A anthraquinone isolated from Rheum emodi. Has antitumor and antifungal activity. CAS # 521-61-9

Phytic Acidsc-205806A constituent of wheat bran shown to have antineoplastic action in coloncarcinogenesis. This compound inhibits cell differentiation and cell proliferation. CAS # 83-86-3

Pristimerinsc-281138An triterpenoid and an antitumor agent. Induces caspase-dependent apoptosis by inhibiting the chymotrypsin-like activity of the proteasome. CAS # 1258-84-0

Procarbazine Hydrochloridesc-204862An antineoplastic agent. CAS # 366-70-1

Psoralidinsc-202779A compound with cytotoxicity against stomach cancer cell lines, antibacterial activity and inhibitive activity against both constitutive and EGF-induced EGFR activation. CAS # 18642-23-4

PX 12sc-358518PX 12 is an irreversible and competitive inhibitor of thioredoxin-1 (Trx-1). CAS # 141400-58-0

R-848sc-203231R-848 is a low-molecular-weight immune response modifier. A TLR7 and TLR8 (Toll-like receptor) activator. It is reported to possess anti-tumor and anti-viral properties. CAS # 144875-48-9

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(R)-(+)-Verapamil Hydrochloridesc-208225Both isomers inhibit p-glycoprotein efflux pump in multidrug resistant tumor cells. CAS # 38321-02-7

Retinyl acetatesc-204878A vitamin A analog that induces cell differentiation and inhibits cell proliferation. A chemopreventive against rat mammary tumors. CAS # 127-47-9

Risedronic acidsc-203239A biophosphonate that displays potent inhibition of bone resorption. Shown to prevent bone metastases in rats. CAS # 105462-24-6

Roquefortine Esc-202324Analogue of Roquefortine C containing an additional isoprenyl unit on the imidazole similar to phenylhistin. Roquefortine E is a selective, albeit weak, antitumor agent. CAS # 871982-52-4

(S)-(-)-Verapamil Hydrochloridesc-208338Both isomers inhibit p-glycoprotein efflux pump in multidrug resistant tumor cells. CAS # 36622-29-4

Saquayamycin B1sc-364135 CAS # 99260-68-1

Sarcophinesc-202802Inhibitor of acetylcholine esterase and ATPase. Ichthyotoxin. Tumorigensis and JB6 cell transformation inhibitor. CAS # 55038-27-2

Septicinesc-202810Septicine is a biogenetic precursor of the alkaloid tylophorine and is a indolizidine alkaloid. CAS # 42922-10-1

Sodium dichloroacetatesc-203275Shown to induce mitochondrial-dependent apoptosis and decrease cell proliferation. Also found to inhibit gluconeogenesis and stimulate peripheral glucose utilization. CAS # 2156-56-1

Sphingosine Kinase Inhibitorsc-208400Sphingosine Kinase Inhibitor is an inhibitor of SphK. CAS # 1177741-83-1

SR 11237sc-296418A pan retinoid X receptor (RXR) agonist that is devoid of any RAR activity. CAS # 146670-40-8

SR 11302sc-204295Inhibitor of activator protein-1 (AP-1) transcription factor activity that displays antitumor effects in vivo. Does not activate transcription from the retinoic acid response element (RARE) and also does not display activity at retinoic acid receptors (EC50 > 1 μM for RARα, RARβ, RARγ and RXRα). CAS # 160162-42-5

Stevensinesc-203283Dibrominated alkaloid. Deters feeding of predatory fishes. Exhibits antitumor and weak antimicrobial activity. CAS # 99102-22-4

R-(-)-Glucoraphanin Potassium Saltsc-359618R-(-)-Glucoraphanin Potassium Salt is a modulator of hepatic cytochrome P450 and phase II conjugation activity. The enzyme myrosinase transforms glucoraphanin into R-Sulforaphane (sc-203099). CAS # 21414-41-5

Tegafursc-205855Clinical antitumor agent related to 5-fluorouracil used in conjunction with antineoplastic drugs. CAS # 17902-23-7

Temozolomidesc-203292An antitumor and antiangiogenic compound that is believed to work by alkylating DNA, thereby triggering apoptosis. CAS # 85622-93-1

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Rb/Raf-1 Disruptor 251sc-222244Rb/Raf-1 Disruptor 251 is a cell-permeable and orally active isothiouronium compound which potently and selectively disrupts the Rb/Raf-1 interaction.

Tenoxicamsc-205856Nonsteroidal anti-inflammmatory, analgesic agent. Displays antitumor effects. CAS # 59804-37-4

Terazosin Hydrochloride dihydratesc-205857An a1-selective blocker. Its inhibitory effect on prostate tumor growth may be the result of antiangiogenic activity. CAS # 70024-40-7

TN-16sc-204347TN-16 is a synthetic antitumor drug that blocks microtubule assembly by binding to the colchicine site of Tubulin. The compound also blocks the cell cycle in M phase. CAS # 33016-12-5

Tubulin Polymerization Inhibitorsc-222377Tubulin Polymerization Inhibitor is a low molecular weight, cell-permeable, benzylidene-anthracenone antimicrotubule agent that exhibits potent antitumor activity.

Tylophorinesc-202372Phenanthroindolizidine alkaloid with antitumor activity. Suppressor of iNOS and COX-2. Enhances Akt phosphorylation and decreases c-Jun expression and phosphorylation. CAS # 111408-21-0

Ursodeoxycholic acidsc-204935A bile acid with significant colon chemopreventive activity. CAS # 128-13-2

RRD-251 hydrochloridesc-215822A reversible, potent, and selective disruptor of Rb/Raf-1 interaction; significantly inhibits angiogenesis and tumor growth in vivo in an Rb-dependent manner. CAS # 72214-67-6

S-Trityl-L-cysteinesc-202799S-Trityl-L-cysteine is a cell-permeable cysteine thioether compound that exhibits antitumor and antimitotic properties by inhibiting mitotic kinesin Eg5. CAS # 2799-07-7

Veratraminesc-208484Useful as a signal transduction inhibitor for treating tumors. CAS # 60-70-8

Vindolinesc-204940Monomeric vinca-alkaloid, forms lower portion of the lead anti-tumor agents, vinblastine and vincristine. Exhibits reciprocal cross-resistance to vincristine and vinblastine. CAS # 2182-14-1

Vinflunine Ditartratesc-216058Semisynthetic Vinca alkaloid with microtubule destabilizing and antiangiogenic activity. It is an antineoplastic derivative of Vinorelbine. CAS # 194468-36-5

Vinleurosine sulfatesc-205884An antineoplastic agent. CAS # 54081-68-4

Vinorelbine ditartrate salt hydratesc-216059A potent anti-mitotic, anti-tumor agent that inhibits microtubule assembly by interacting with Tubulin. CAS # 125317-39-7 (anhydrous)

Xanthomegninsc-364147 CAS # 1685-91-2

YK-4-279sc-280194An inhibitor of the protein-protein interaction between ES-FLI1 to RNA helicase A. CAS # 1037184-44-3

Zerumbonesc-364148 CAS # 471-05-6

Xanthohumol from hop (Humulus lupulus)sc-301982Xanthohumol has demonstrated antiproliferative and cytotoxic effects in human cancer cell lines and also has an inhibitory effect on oxidative enzymes such as CYP. CAS # 6754-58-1

Zebularinesc-203315Zebularine is a cell-permeable chemically stable cytidine analog that has been shown to inhibit DNA methyltransferase (Dnmt). CAS # 3690-10-6

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