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PRODUCT NAMECATALOG #DESCRIPTIONCITATIONSRANKING
4-phenyl-5-methyl-1,2,3-Thiadiazolesc-2051224-phenyl-5-methyl-1,2,3-Thiadiazole is a selective, mechanism-based inhibitor of CYP2B4 and CYP2E1 at a concentration of 100 µM that does not inactivate CYP1A2.1 1,2,3-Thiadiazole compounds and their derivatives, including 4-phenyl-5-methyl-1,2,3-thiadiazole, are also commonly used as herbicides, fungicides, and plant growth regulators. CAS # 64273-28-5

5-Hydroxy-2-methyl-4-chromanonesc-364093 CAS # 14153-17-4

Cercosporamidesc-202095Cercosporamide, an usnic amide is a potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2) and JAK3 (IC50 values are 11, 31 and 116 nM for Mnk2, JAK3 and Mnk1 respectively). CAS # 131436-22-1

10’-Desmethoxystreptonigrinsc-202004An analog of Streptonigrin. Demonstrates inhibition of the farnesylation of RAS oncogene p21 protein. CAS # 136803-89-9

Actinopyrone Asc-202036A compound with documented activity against Helicobacter pylori that is both potent, with an MIC 0.0001 CAS # 88378-59-0

Aerothioninsc-202446Bromotyrosine derivative with antimycobacterial activity. CAS # 28714-26-3

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Hypothemycinsc-203078Hypothemycin is a selective MEK inhibitor that exhibits antifungal and antitumor properties. CAS # 76958-67-3

[Ala8,13,18]-Magainin II amidesc-214514A magainin analog that possesses greater anti-microbial activity. CAS # 117665-48-2

Altenusinsc-202454Antifungal penicillide. Non-competitive, specific N-SMase and strong pp60 c-Src inhibitor. Inhibits cFMS receptor tyrosine kinase. Myosin light chain kinase inhibitor. Exhibits anti-HIV-1 integrase activity. CAS # 31186-12-6

Alternariol monomethyl ethersc-206070Mycotoxin that commonly contaminates fruit and cereal products. Displays antifungal, DNA strand-breaking and phytotoxic activity. Inhibits actions of topoisomerase IIα in mammalian cell models. CAS # 26894-49-5

Altersolanol Asc-202455Tetrahydroanthraquinone with phytotoxic and antibacterial activity CAS # 22268-16-2

Amphotericin B trihydratesc-227265A polyene antifungal and antibiotic that forms channels in fungal membranes inducing non-specific loss of low molecular weight molecules to leak out. CAS # 1397-89-3

Amphotericin Bsc-202462A polyene antifungal and antibiotic that forms channels in fungal membranes inducing non-specific loss of low molecular weight molecules. CAS # 1397-89-3

Anguinomycin Asc-202054Anguinomycin A displays nanomolar cytotoxicity to murine P388 leukemia cells. Anguinomycin A is an analogue of Leptomycin B, an inhibitor of nuclear export of proteins. CAS # 111278-01-4

Antibiotic TAN 420Csc-202057Hydroquinone analog of herbimycin C, which is known to exhibit antitumor activity and has been shown to convert RSV-infected rat kidney cells into normal cells. CAS # 91700-91-3

Antibiotic TAN 420Esc-202058Hydroquinone analogue of herbimycin A. Patented as an antibacterial, antifungal and antiprotozoan reagent. CAS # 91700-93-5

Antibiotic TPU-0037-Asc-202059TPU-0037A, a close structural analogue of lydicamycin, is highly active against MRSA. TPU-0037A is also closely related to Antibiotic BN 4515N. CAS # 485815-59-6

Antibiotic TPU-0037-Csc-202060An antibiotic with activity against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). CAS # 485815-61-0

Ascolactonesc-364102 CAS # 757995-43-0

Aureothinsc-202478Inhibits oxidoreductase. Has broad biological actions including antitrypanosomal, antibacterial (against Helicobacter pylori), antitumor, antifungal, insecticidal, pesticidal activities. CAS # 2825-00-5

Gatifloxacinsc-204762Gatifloxacin is a fluoroquinolone antibiotic, with potent activity against Gram-negative and Gram-positive bacteria and is a Topo II inhibitor. CAS # 112811-59-3

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Aureothricinsc-202069More hydrophobic analogue of thiolutin. Thiolutin is a potent inhibitor of bacterial and yeast RNA polymerases, of mannan and glucan formation in fungi and of tumor cell induced angiogenesis in vivo. CAS # 574-95-8

Avarolsc-202480Cytostatic agent with potent antileukemic activity both in vitro and in vivo (mice). Displays antibacterial and antifungal activities against a limited range of microorganisms. Inhibits HIV-1 RT. CAS # 55303-98-5

Avaronesc-202481Cytostatic agent with potent antileukemic activity both in vitro and in vivo (mice). Also displays antibacterial and antifungal activities against a limited range of microorganisms. CAS # 55303-99-6

Azithromycin Dihydratesc-210854A semi-synthetic macrolide antibiotic that is related to Erythromycin A. It is also an antibacterial. CAS # 117772-70-0

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Biapenemsc-204651A parenteral carbepenem that exhibits antibacterial activities against a wide range of gram-positive and gram-negative bacteria. CAS # 120410-24-4

Bicyclomycin benzoate sc-362713Bicyclomycin is a polar metabolite first isolated from Streptomyces sapporonensis in 1972 with activity against Gram negative bacteria. The selective Gram negative profile of bicyclomycin is rare among Streptomyces metabolites, and in an effort to overcome its poor in vivo absorption, the benzoate ester was prepared by reaction with the more exposed primary alcohol. Bicyclomycin benzoate has limited use as a veterinary antibiotic. CAS # 38129-37-2

Bifonazolesc-204652An imidazole antifungal agent and calmodulin antagonist. It causes a reduction in glycolysis and ATP levels in B16 melanoma cells. CAS # 60628-96-8

Bischloroanthrabenzoxocinonesc-202079Inhibitor of Type II fatty acid synthesis. Type II fatty acid synthesis (FASII) is essential to bacterial cell viability and is a promising target for the development of novel antibiotics. CAS # 866022-28-8

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Boric Acidsc-202083Commonly used in molecular biology applications such as gel electrophoresis. CAS # 10043-35-3

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Ofloxacinsc-219475Ofloxacin is a fluorinated quinolone antibacterial. Ofloxacin functions by inhibiting DNA gyrase, a Topo II (topoisomerase II) and Topo IV (Topo II alpha). CAS # 82419-36-1

Butoconazole nitratesc-205987Imidazole antifungal used in gynecology. CAS # 64872-77-1

Carbadoxsc-204668Broad spectrum antimicrobial agent. CAS # 6804-07-5

Carbenicillin disodium saltsc-202519Carbenicillin is a penicillin-derived, β-lactam antibiotic which inhibits the synthesis of peptidoglycan, a key component of the bacterial cell wall. CAS # 4800-94-6

Cefaclor, Monohydratesc-205242Antimicrobial agent. Has a broad spectrum of activity against the most common gram-positive and gram-negative respiratory tract pathogens. CAS # 70356-03-5

Cefazolin sodium saltsc-202533Inhibits synthesis of bacterial cell wall. CAS # 27164-46-1

Cefoperazone Acidsc-204677Antimicrobial agent, possesses potent β-lactamase inhibitory properties. CAS # 62893-19-0

Cefoperazone Sodiumsc-204678Antimicrobial agent useful for prevention of postoperative infection. Inhibitor of inactivation of α-antitrypsin. CAS # 62893-20-3

Cefotiam Hexetil Hydrochloridesc-211042Antibacterial. A semi-synthetic cephalosporin antibiotic. Antibacterial. CAS # 95789-30-3

Cefozopran Hydrochloridesc-211043Antibacterial. CAS # 113359-04-9

Cefaloniumsc-300330 CAS # 5575-21-3

Ceftazidimesc-205243Antimicrobial agent. It is used for treating febrile neutropenia in patients with cancer. CAS # 72558-82-8

Ceftibuten Dihydratesc-211048An antibacterial. CAS # 118081-34-8

Ceftiofur Hydrochloridesc-202990A cephalosporin antibiotic. The compound is a derivative of a third generation cephalosporin, Ceftiofur. CAS # 103980-44-5

Ceftriaxone, Disodium Salt, Hemiheptahydratesc-211050Used as an antibacterial agent. CAS # 104376-79-6

Celastramycin Asc-293989Celastramycin A is a bioactive compound isolated from endophytic bacteria living in plants of the Celastraceae family. This benzoyl pyrrole inhibits the growth of bacteria and mycobacteria, with a minimal inhibitory concentration as low as 0.05 μg/ml. Celastramycin A also suppresses the production of interleukin-8 in human umbilical vein endothelial cells as stimulated by tumor necrosis factor-α (IC50 = 0.01 μg/ml). CAS # 491600-94-3

Cetylpyridinium chloride monohydratesc-239495 CAS # 6004-24-6

Chetominsc-202535Chetomin inhibits HIF (hypoxia-inducing factor) binding to the transcriptional coactivator p300. CAS # 1403-36-7

Chrysophanolsc-205631An anthraquinone found in the root of Rheum wittrochii. It has been shown to increaseintracellular Ca2+ concentration and exhibit antifungal activities. CAS # 481-74-3

Ciclopirox Olaminesc-204688A substituted pyridone antimycotic. Has activity against a broad spectrum of dermatophytes, yeasts, actinomycetes, molds, other fungi, and a variety of bacteria. CAS # 41621-49-2

Cinoxacinsc-202543An antibacterial quinolone analog of oxolinic acid which inhibits DNA gyrase as well as topoisomerase IV. Due to the inhibiting activity of Cinoxacin the compound has displayed toxicity against eukaryotic cells. CAS # 28657-80-9

CJ-21058sc-364107 CAS # 405072-57-3

Cladospirone bisepoxidesc-202546A selective antibiotic commonly used as an antifungal and anitmicrobial agent which inhibits the germination of Lepidium sativum and suppresses the growth of several microorganisms. CAS # 155866-40-3

Climbazolesc-204691Potent inducer and inhibitor of P450-dependent drug metabolizing enzymes, which is also used as antifungal and antidandruff agent. CAS # 38083-17-9

Clinafloxacinsc-202107A fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumoniae. CAS # 105956-97-6

Concanamycin Asc-202111Concanamycin A, also designated, Folimycin is an inhibitor of vacuolar type H+-ATPase (V-ATPase) activity, it inhibits perforin-based cytotoxic activity in CD8+ T cells and intracellular protein trafficking in both plant and animal cells. CAS # 80890-47-7

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Cordycepinsc-203902Nucleoside analog that acts as an anticancer and antifungal agent. Inhibits growth of various tumor cells in vitro. Can be converted to 3'-deoxyadenosine triphosphate (3'-dATP), which inhibits ATP-dependent DNA synthesis. CAS # 73-03-0

Cyproconazolesc-205641A triazole fungicide which has been observed in CD-1 mice to cause hepatocellular adenomas and carcinomas. CAS # 94361-06-5

Dalfopristin (as mesylate)sc-362728Dalfopristin is a semi-synthetic analogue of ostreogyrcin A (virginiamycin M, pristinamycin IIA, streptogramin A) formed by addition of diethylaminoethylthiol to the 2-pyrroline group of ostreogyrcin, followed by oxidation to the sulphone. The structural changes provide a more hydrophobic compound with a readily ionisable group for generating a salt. Dalfopristin is used commercially in synergistic combination with quinupristin (70:30). There is little published data on the synthesis, biological or antibiotic activity of dalfopristin alone, however the combination product is highly effective, including activity against antibiotic resistant strains. CAS # 112362-50-2

Danofloxacinsc-204707A synthetic fluoroquinone with broad spectrum anti-bacterial activity. A veterinary treatment for respiratory diseases in cattle, chickens and swine. CAS # 112398-08-0

Demeclocycline Hydrochloridesc-204710Antibiotic related to tetracycline and produced by streptomyces aureofaciens. Excretes more slowly than tetracycline, thus maintains effective blood levels for longer periods of time. CAS # 64-73-3

Deoxyenterocinsc-362729Deoxyenterocin is a minor co-metabolite of enterocin produced by several species of Streptomyces. Interestingly, deoxyenterocin was first isolated from an ascidian. Like enterocin, deoxyenterocin exhibits activity against both Gram positive and Gram negative bacteria but lack of availability has restricted a more CAS # 108605-51-2

Difenoconazolesc-204721Metabolizes glucosinolates which increase the production of isothiocyanates. CAS # 119446-68-3

Doxycycline Hyclatesc-211380An antibacterial. CAS # 564-25-0

Elaiophylinsc-202147A highly characteristic macrolide antibiotic with antifungal, antitumor, anithelminthic and immunosuppressant properties. CAS # 37318-06-2

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Enoxacinsc-205670Quinolone antibacteral agent. Acts on DNA gyrase. CAS # 74011-58-8

Enrofloxacinsc-203040An antibiotic with a broad spectrum against gram-positive and gram-negative bacteria, as well as Mycoplasma spp., that also acts as a DNA gyrase inhibitor. CAS # 93106-60-6

Erythromycin Bsc-362735Erythromycin B (12-deoxyerythromycin A) is a minor co-metabolite of erythromycin produced by fermentation of Saccharopolyspora erythreae. Erythromycin B exhibits broad spectrum antibiotic activity,albeit less potent than erythromycin A. Erythromycin B played an integral part of the structure activityrelationship studies of semi-synthetic erythromycins, however none reached clinical development. CAS # 527-75-3

Erythromycin Csc-362736Erythromycin C (3’’-O-demethylerythromycin A) is a minor co-metabolite of erythromycin produced by fermentation of Saccharopolyspora erythreae. Erythromycin C exhibits a narrower spectrum of antibiotic activity and is much less active than erythromycins A and B. CAS # 1675-02-1

Erythromycin Estolatesc-211423An antibacterial agent with an LD50 >5000 mg/kg for oral administration to rats. CAS # 3521-62-8

Erythromycin Thiocyanatesc-205680An antimicrobial agent. CAS # 7704-67-8

Ethacridine Lactate Monohydratesc-205315Antiseptic agent that makes an effective abortifacient. CAS # 6402-23-9

Ethambutolsc-205684An antibacterial agent. CAS # 74-55-5

Ethambutol Dihydrochloridesc-207645A tuberculostatic antibacterial. CAS # 1070-11-7

Ethionamidesc-211429An antibacterial (tuberculostatic). CAS # 536-33-4

Fenoxanilsc-223987 CAS # 115852-48-7

Fidaxomicinsc-362739Fidaxomicin is a recently approved antibiotic with a confusing history dating back to its original isolation in 1975. Fidaxomicin is the major analogue of a family of macrocyclic lactones isolated independently by three different groups from cultures belonging to three different genera (Actinoplanes, Dactylosporangium and Micromonospora) known as lipiarmycin A3, tiacumicin B and clostomicin B1, respectively. Fidaxomicin is a narrow spectrum antibiotic with excellent activity against Gram positive bacteria, notably Clostridium difficile. Fidaxomicin acts in the gastrointestinal tract without undue disruption to gut microbial flora. CAS # 873857-62-6

Fleroxacinsc-205694An antibacterial agent with antiproliferative effects. CAS # 79660-72-3

Florfenicolsc-205696Florfenicol is a fluorinated synthetic analog of thiamphenicol and broad spectrum antibiotic. CAS # 73231-34-2

Fluconazolesc-205698A triazole broad-spectrum antifungal agent which is effective against Candida spp., cryptococcus neoformans and dermatophytes. CAS # 86386-73-4

gamma-Rubromycinsc-364111 CAS # 27267-71-6

Gemifloxacin Mesilatesc-211557A third generation antibacterial quinolone agent that is also fluorinated. CAS # 210353-53-0

Gentamicin C1asc-207712An antibacterial agent that is closely related to Gentamicin A. Has also been shown to affect mainly gram-negative bacteria. CAS # 26098-04-4

Gentamicin Sulfate, 100X Solutionsc-361877An aminoglycoside antibiotic which acts by inhibiting protein synthesis in susceptible bacteria. It is active against many strains of Gram-negative bacteria, Pseudomonas aeruginosa, the Gram-positive Staphyloccus aeruginosa as well as some strains of Mycobacterium tuberculosis and mycoplasmas. CAS # 1405-41-0

Gentamicin Sulfate, 500X Solutionsc-29066Aminoglycosidic antibiotic for gram-negative and gram-positive bacteria, which inhibits protein synthesis and has been shown to bind to the outer membrane of gram-negative cells. CAS # 1405-41-0

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Gilvocarcin Vsc-202170Gilvocarcin V contains a vinyl group in the 8-position and is the most potent analogue of the complex. It is thought to act as an inhibitor of the catalytic activity of human topoisomerase II. CAS # 77879-90-4

Griseofulvinsc-202171An antifungal agent that has been reported to inhibit proliferation of various types of cells. Also has been shown to cause mitotic arrest by affecting microtubules. CAS # 126-07-8

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Hassallidin Asc-221705Broad spectrum antifungal compound. Active against Candida, Acremonium, Cryptococcus neoformans, Trichosporon, Aspergillus, Fusarium sambucium (minimal inhibition concentration (MIC) range: 4-16μg/ml). Moderate activity against cancerous cells (Jurkat ATCC-TIB-152, L 929). No activity against bacteria (Bacillus subtilis, Streptomyces versicolor, Escherichia coli).

Hassallidin Bsc-221706Broad spectrum antifungal compound. Active against Candida, Acremonium, Cryptococcus neoformans, Trichosporon, Aspergillus, Fusarium sambucium (minimal inhibition concentration (MIC) range: 4-16μg/ml). Moderate activity against cancerous cells (Jurkat ATCC-TIB-152, L 929). No activity against bacteria (Bacillus subtilis, Streptomyces versicolor, Escherichia coli).

Hexachlorophenesc-211587An antiseptic. CAS # 70-30-4

Hymeglusinsc-203077A fungal β-lactone cell wall-targeting antibiotic that irreversibly inhibits cytosolic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase by covalently modifying the active Cys 129 residue of the enzyme. CAS # 29066-42-0

Ikarugamycinsc-202179An antiprotozoal macrolactam antibiotic with cytostatic effects and activity against gram-positive bacteria. Demonstrated to inhibit oxidized LDL-induced accumlation of cholesteryl ester in macrophage J774. CAS # 36531-78-9

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Imazalilsc-204775A fungicide widely used in agriculture, particularly in the growing of citrus fruits. Has carcinogenic potential. CAS # 35554-44-0

Itraconazolesc-205724Itraconazole inhibits the fungal cytochrome P450 oxidase-mediated synthesis of ergosterol. It also acts as an effective hedgehog signaling inhibitor in a Ptch-independent manner. CAS # 84625-61-6

Kanamycin Asc-205358An antibiotic that belongs to the family of aminoglycosides and associates with ribosomal RNA by forming a complex at the bacterial ribosomal A site. CAS # 59-01-8

Kijanimicinsc-202198A tetronic acid that behaves as a portent antibacterial compound. CAS # 78798-08-0

Lateropyronesc-202206Heterocyclic metabolite with antibacterial and antifungal activity. Independently characterised as Antibiotic Y and found to be an important metabolite marker for strains of Fusarium avenaceum. CAS # 93752-78-4

Leptomycin Asc-203102Antifungal antibiotic that acts as an inhibitor of nuclear export by interacting with CRM1/exportin-1. CAS # 87081-36-5

Leucomycin A13sc-362761 CAS # 78897-52-6

Leucomycin A4sc-362762Leucomycin A4 is a major metabolite from the leucomycin complex, a family of closely related macrocyclic lactone antibiotics produced by Streptomyces kitasatoensis and discovered in 1953. Leucomycin A4 is one of the more potent antibiotics of the complex. Leucomycin complex (kitasamycin) is used as an animal health product for control of Gram positive bacteria, Gram negative cocci, leptospira and mycoplasma. Little is known about the activity of individual analogues within the complex as their limited availability has restricted investigation. CAS # 18361-46-1

Leucomycin A5sc-362763Leucomycin A5 is a major metabolite of the leucomycin complex, a family of closely related macrocyclic lactone antibiotics produced by Streptomyces kitasatoensis and discovered in 1953. Leucomycin A5 is one of the more potent antibiotics of the complex. Leucomycin complex (kitasamycin) is used as an animal health product for control of Gram positive bacteria, Gram negative cocci, leptospira and mycoplasma. Little is known about the activity of individual analogues within the complex as their limited availability has restricted investigation. CAS # 18361-45-0

Levofloxacin hydrochloridesc-202693A fluoroquinolone antibiotic agent, the active S-(-) isomer of the antibacterial agen ofloxacin. Inhibits DNA gyrase and topoisomerase IV activity. CAS # 177325-13-2

Lysolipin Isc-364118 CAS # 59113-57-4

Magnololsc-204797Highly tolerable, potent antitumor and antiangiogenic compound which exhibits anxiolytic, anti-thrombotic and antibacterial properties. CAS # 528-43-8

Miconazolesc-204806An antifungal agent with good aromatase inhibitory activity. Discovered to be an effective chemopreventive agent in a rat mammary cancer model. CAS # 22916-47-8

Miconazole Nitratesc-205753Topical antifungal agent found to inhibit platelet cyclooxygenase. CAS # 22832-87-7

Midpacamidesc-205954An alkaloid. Has antimicrobial activity. CAS # 66067-05-8

MM 47755sc-202708Angucyclinone. Displays antibacterial and antifungal activity. CAS # 117620-87-8

Moxifloxacin Hydrochloridesc-205758An 8-methoxy-fluoroquinone inhibitor of DNA gyrase and topoisomerase IV activity. Demonstrates broad-spectrum bactericidal efficacy against gram-positive and gram-negative strains. CAS # 186826-86-8

MreB Perturbing Compound A22sc-204100A cell-permeable isothiourea compound that specifically, rapidly and reversibly perturbs MreB function without affecting eukaryotic actin polymerization. CAS # 22816-60-0

Mutolidesc-364121 CAS # 277749-34-5

Myclobutanilsc-205759A fungicide that inhibits ergosterol biosynthesis. CAS # 88671-89-0

N-Acetyl Amphotericin Bsc-212073An Amphotericin B CAS # 902457-23-2

Nadifloxacinsc-202723A cell-permeable, synthetic, broad-spectrum antibiotic that inhibits the growth of both gram-positive and gram-negative microbes. CAS # 124858-35-1

Nadifloxacinsc-204814A fluoroquinolone antibacterial agent found to inhibit the generation of O2- and OH radicals by neutrophils. CAS # 124858-35-1

Nalidixic acid sodium saltsc-215532Inhibits bacterial DNA gyrase and avian myeloblastoma virus reverse transcriptase. The compound inhibits nucleic acid and protein synthesis in Saccharomyces cerevisiae. CAS # 3374-05-8

Neoaureothinsc-202242A chain-extended analogue of aureothin first reported as a co-metabolite of neoantimycin. Two photo-isomers of neoaureothin, Antibiotics SNF4435C and D, show potent immunosuppression. CAS # 28900-27-8

Nidulinsc-202244Depsidone with antibacterial activity. Closely related to folipastatin and unguinol, identified inhibitors of PLA2, arachidonic acid release from rat polymorphonuclear leukocytes. CAS # 10089-10-8

Nitrothal-isopropylsc-224170 CAS # 10552-74-6

Nodusmicinsc-362771Nodusmicin is a co-metabolite of nargenicin bearing the core macrocyclic lactone but lacking the pyrrole ester. Like nargenicin, nodusmicin is a potent antibiotic against both aerobic and anaerobic bacteria. Lack of availability has restricted a more extensive investigation of nodusmicin. CAS # 76265-48-0

Norfloxacin nicotinatesc-202740A derivative of norfloxacin with improved solubility in water that inhibits bacterial DNA replication by interfering with an ATP-induced structural transition of DNA complexed with DNA gyrase. CAS # 118803-81-9

Nornidulinsc-202252Depsidone antibacterial activity. Closely related to folipastatin and unguinol identified as inhibitors of PLA2, arachidonic acid release from rat polymorphonuclear leukocytes. CAS # 33403-37-1

O-Deacetylravidomycinsc-202253O-deacetylravidomycin is the more active and stable analogue of the ravidomycin complex. Shows potent, light dependent antitumor activity. Possible topoisomerase II inhibitor. CAS # 88580-27-2

Ophiobolin Asc-202266Acts as an inhibitor of calmodulin action in calcium regulation. Possesses a broad biological profile with antibacterial, antifungal, antitumor and nematocidal activiites. CAS # 4611-05-6

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Ophiobolin Bsc-202267Originally isolated from Helminthosporium sp. Inhibitor of calmodulin action in calcium regulation. Exhibits antibacterial, antitumor and nematocidal activities. CAS # 5601-74-1

Oxiconazole Nitratesc-205783An antifungal agent. CAS # 64211-46-7

Oxytetracycline Hydrochloridesc-205785Antibacterial compound isolated from the elaboration products of the actinomycete, Streptomyces rimosus, when grown on a suitable medium. CAS # 2058-46-0

Palmarumycin C3sc-364123 CAS # 159934-11-9

Papuaminesc-202274A pentacyclic alkaloid with antifungal and antimycobacterial activity with a C2-symmetric structure. CAS # 112455-84-2

Pazufloxacin Mesylatesc-205793A fluoroquinolone antimicrobial agent having a wide range of activities and potent actions against both gram-positive and gram-negative bacteria. CAS # 163680-77-1

Pefloxacin mesylate dihydratesc-204838Analog of norfloxacin. Fluoroquinolone antibacterial agent and prevents bacterial DNA replication by inhibiting DNA gyrase (topoisomerse). Very effective against Staphylococcus aureus, E. coli, other enterobacteria and Pseudomonas aeruginosa. High effectivity against Gram-negative bacteria and Gram-positive bacteria. CAS # 149676-40-4

Penicillin V Potassiumsc-204839A bactericidal against penicillin-susceptible microorganisms during the stage of active multiplication. It inhibits biosynthesis of cell-wall mucopeptide. CAS # 132-98-9

Picoxystrobinsc-224206 CAS # 117428-22-5

Pimaricin, Streptomyces chattanoogensissc-203197Pimaricin, Streptomyces chattanoogensis is an antifungal macrolide polyene that binds to cell membrane sterols. Predominantly binds to ergosterol, and causes the bacterial membranes to become porous CAS # 7681-93-8

Piperacillinsc-205807Semisynthetic penicillin with wide spectrum of antimicrobial activity. CAS # 61477-96-1

Piperacillin sodiumsc-205808Antibiotic related to penicillin. CAS # 59703-84-3

Piromidic Acidsc-296098Shown to have antibacterial properties. CAS # 19562-30-2

Polymixin E complexsc-362784 CAS # 1066-17-7 (for Polymyxin E1)

Polyoxin D, Streptomyces cacaoi var. asoensissc-204209Specific inhibitor of fungal chitin synthetase (Ki = 6 µM). CAS # 22976-86-9

Povidone iodinesc-204855A topical antiseptic. CAS # 25655-41-8

Prothionamidesc-204865Antibacterial used againstMMycobacterium tuberculosis bacteria. CAS # 14222-60-7

Prulifloxacinsc-204868Fluoroquinolone with broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. CAS # 123447-62-1

Pseudoanguillosporin Asc-364129 CAS # 1159392-22-9

Pyrazinamidesc-205824An antibacterial used in tuberculosis therapy commonly in combination with rifampicin. CAS # 98-96-4

Quinomycin Asc-202306Quinomycin A exhibits various antibiotic, antiviral, and antitumor activity. Quinomycin A reportedly inhibits HIF by blocking binding of HIF-1α and HIF-1β proteins to a HRE sequence. CAS # 512-64-1

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Quinupristinsc-362787Quinupristin is a semi-synthetic analogue of virginiamycin B (ostreogyrcin B, pristinamycin IA, Streptogramin B) formed by a Mannich condensation and elimination to generate an exocyclic methylene alpha to the ketone of the 4-piperidinone. Addition of quinucidinylthiol to the methylene group affords quinupristin. The structural changes provide a more hydrophobic compound with a readily ionisable group for generating a salt. Quinupristin is used commercially in synergistic combination with dalfopristin (30:70). There is little published data on the synthesis, biological or antibiotic activity of quinupristin alone, however the combination product is highly effective, including activity against antibiotic resistant strains. CAS # 120138-50-3

(R)-Semivioxanthinsc-364131 CAS # 70477-26-8

Rifabutinsc-208307A semisynthetic derivative of Rifamycin S. An antibacterial (tuberculostatic) that inhibits nucleic acid synthesis. CAS # 72559-06-9

Rifamycin SV monosodium salt sc-205839An antimicrobial agent which inhibits DNA polymerase. CAS # 14897-39-3

Ronidazolesc-212789An anti-microbial. CAS # 7681-76-7

Roxithromycinsc-205845An antibiotic with an immunomodulatory effect and a wide antibacterial spectrum against oral pathogens. It has also been shown to increase neutrophil apoptosis, inhibit pulmonary metastasis of B16BL6 cells and reduce tumor size of B16BL6 melanoma. CAS # 80214-83-1

Rufloxacin Hydrochloridesc-202326A fluoroquinolone antibacterial that shows photosensitizing properties toward biological substrates. It inhibits B-cell differentiation in human mononuclear cells. CAS # 106017-08-7

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Rugulosin (+ form)sc-202327Rugulosin is an intense yellow pigment produced by some fungal species of Penicillium, Aspergillus and the fungal symbiotants of some lichens. Shows antibacterial and insecticidal activity. CAS # 23537-16-8

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(S)-(+)-Ascochinsc-364133 CAS # 935699-58-4

Saccharocarcin Asc-202330An unusual tetronic acid structurally related to kijanimicin, chlorothricin, tetrocarcins and versipelostatin which has pronounced activity against Gram positive bacteria and Chlamydia trachomatis. CAS # 158475-32-2

Saccharocarcin Bsc-202331An unusual tetronic acid structurally related to kijanimicin, chlorothricin, tetrocarcins and versipelostatin which has pronounced activity against Gram positive bacteria and Chlamydia trachomatis. CAS # 158475-33-3

Sandramycinsc-202333A bisintercalating cyclic depsipeptide antibiotic. Demonstrates potent antitumor effects. CAS # 100940-65-6

Sarafloxacin hydrochloridesc-203255Fluoroquinolone antibacterial agent. Inhibits bacterial DNA gyrase (topoisomerase). Effective against Mycobacterium tuberculosis. CAS # 91296-87-6

Sparfloxacinsc-202343Fluoroquinolone with broad spectrum antibacterial activity. Inhibits bacterial DNA gyrase (topoisomerase). Effective against Mycobacterium tuberculosis. Shows photosensitizing effects. CAS # 110871-86-8

Spiroxaminesc-224291 CAS # 118134-30-8

Streptonigrinsc-202347An aminoquinone with antitumor and broad spectrum antibiotic. The compound functions through DNA, RNA and topoisomerase II synthesis inhibition, induces DNA strand breaks after reduction with NADH, induces unscheduled DNA synthesis and DNA adducts. CAS # 3930-19-6

Strobilurin Bsc-364141 CAS # 65105-52-4

Sulfaphenazolesc-215926A specific inhibitor of CYP2C9 which blocks atherogenic and pro-inflammatory effects of linoleic acid (increase in oxidative stress and activation of AP-1) mediated by CYP2C9. Acts as an antibacterial and antimicrobial. CAS # 526-08-9

Sultriecinsc-202350Dominant analogue in a family of sulphate esters of a triene antibiotic. Despite the structural similarity to fostriecin, there is little comparative data to support a common mode of action. CAS # 131774-59-9

Swinholide A, Theonella swinhoeisc-205914A membrane permeable marine cytotoxic macrolide that acts as a specific inhibitor of actin filaments and disrupts the actin-cytoskeleton. CAS # 95927-67-6

Tangeretinsc-202826A methoxyflavone compound with antiproliferative, antioxidant, and antiinflammatory effects. Blocks cell cycle progression at G1 in MDA-MB-435, MCF-7, and HT-29 cell lines. Inhibits ERK1/2 phosphorylation in T47D cells. Blocks IL-1β-induced production of COX-2 in A549 cells. CAS # 481-53-8

Tazobactam sodiumsc-205853A beta-lactamase inhibitor and antibacterial. CAS # 89785-84-2

Tazobactam, Free acidsc-205854A beta-lactamase inhibitor and antibacterial. CAS # 89786-04-9

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Tebuconazolesc-204906A triazole fungicide used agriculturally to treat plant pathogenic fungi. It is listed as a potential carcinogen by the EPA. CAS # 107534-96-3

Telavancinsc-362806Telavancin is a semi-synthetic vancomycin analogue prepared by the addition of a decylaminoethyl moiety to the free amino group of the disaccharide. This change increased the hydrophobicity and steric bulk in the northern hemisphere of the molecule, while the addition of a phosphonomethylaminomethyl moiety to the resorcinol group by a Mannich condensation provided a more polar southern hemisphere. Together the changes improved pharmacokinetics and activity against antibiotic resistant strains. CAS # 372151-71-8

Terreinsc-364142 CAS # 582-46-7

Thiabendazolesc-204913A benzimidazole compound that acts as a fungicide and is reported to have aneugenic effects. CAS # 148-79-8

Thiamphenicol Glycinate HClsc-204914Used in the treatment of respiratory infections. CAS # 2611-61-2

Tilmicosin phosphate saltsc-362810Tilmicosin phosphate is the phosphate salt of the semi-synthetic antibiotic derivative of desmycosin (tylosin B), a minor co-metabolite of tylosin, prepared by mixing the active tilmicosin with phosphoric acid to provide improved solubility and enhanced pharmacokinetics. CAS # 137330-13-3

Tinidazolesc-205862A synthesized imidazole derivative used in antiprotozoal treatment with antiamebic and antibacterial properties. CAS # 19387-91-8

Tioconazolesc-205864Antifungal agent that is potent inhibitor of cytochrome-P450. CAS # 65899-73-2

Toltrazurilsc-205867An anticoccidial agent. Its mode of action appears to be a reduction of redox enzymes such as succinate-cytochrome C reductase and NADH oxidase and fumarate oxidase. CAS # 69004-03-1

Tosufloxacin tosylatesc-204920Fluoroquinolone antibacterial agent. Bacterial DNA gyrase (topoisomerase) inhibitor. Effective against Gram-positive and Gram-negative aerobic bacteria, anaerobic bacteria and Chlamydia trachomatis. CAS # 115964-29-9

Triadimefonsc-204923A widely used fungicide. P450 inhibitor, induces brassinosteroid deficiency in plants. CAS # 43121-43-3

Triadimenolsc-205871Triazole-type fungicide. Identified as weak estrogen receptor agonists. CAS # 55219-65-3

Triflumizolesc-204925A pesticide suspected by the EPA to be a cancer causing agent. CAS # 68694-11-1

Triticonazolesc-204929A pesticide suspected by the EPA of being a carcinogen. CAS # 131983-72-7

Tropodithietic acidsc-364145 CAS # 750590-18-2

UK-1sc-202849Antibiotic. Antifungal. Inhibitor of topoisomerase II (Topo II). Mg2+- and Zn2+-dependent DNA binding agent. Displays a wide spectrum of potent anticancer activities. CAS # 151271-53-3

Usnic acidsc-204936An antimicrobial, antitumor and enzyme inhibiting agent shown to uncouple oxidative phosphorylation in mouse-liver mitochondria. Induces necrosis in certain cells. CAS # 125-46-2

Vinclozolin M2sc-205540A dicarboximide fungicide widely used for control of diseases caused by B. cineera, S. sclerotiorum, and Monilinia species in fruits, grapes, ornamental plants, turfgrass and vegetables. CAS # 83792-61-4

Viomelleinsc-364146 CAS # 55625-78-0

(Z)-Metominostrobinsc-224447 CAS # 133408-51-2