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Amides

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PRODUCT NAMECATALOG #DESCRIPTIONCITATIONSRANKING
Deoxymanumycin Asc-391104Deoxymanumycin A is a derivative of the potent Ras farnesyltransferase inhibitor Manumycin A (sc-200857).

Dihydromanumycin Asc-391105Dihydromanumycin A is a derivative of the potent Ras farnesyltransferase inhibitor Manumycin A (sc-200857).

Bisindolylmaleimide IIsc-221366Bisindolylmaleimide II is a general inhibitor of all protein kinase C subtypes. This compound also inhibits PDK1 (IC50 = 14 μM), which is an important kinase in the insulin signaling pathway.

1,1-Cyclohexanediacetic acid monoamidesc-253951 CAS # 99189-60-3

Amaurominesc-391052Amauromine is a potent and selective CB1 (cannabinoid 1) receptor antagonist with antibiotic properties. Also shown to be a Calcium Channel antagonist and vasodilator. CAS # 88360-87-6

AG-490sc-202046AG-490 is a tyrosine kinase inhibitor of JAK2, EGFR, and Neu that belongs to the family of tyrphostins. CAS # 134036-52-5

1
a-Iodoacetamidesc-203320α-Iodoacetamide is an electrophile used for covalent modification of cysteine, methionine, and histidine protein residues. CAS # 144-48-9

α-Mannosyl Ceramidesc-221189α-Mannosyl Ceramide is a strong stimulator of NKT cells expressing the invariant Vα19-Jα26 T cell receptor α chain.

AAL-993sc-221195AAL-993 is a highly potent inhibitor of Flt-1 (VEGFR-1), Flk-1 (VEGFR-2) and Flt-4 (VEGFR-3). AAL-993 is cell permeable, and inhibits VEGF-induced angiogenesis in a mouse model. CAS # 269390-77-4

Closantelsc-202548Antihelmintic agent. CAS # 57808-65-8

BML-244sc-221370BML-244 is a highly potent, cell-permeable inhibitor of cathepsin K (IC50=51 nM). CAS # 440125-24-6

2-(Trifluoromethyl)benzamidesc-223284 CAS # 360-64-5

KN-93sc-202199KN-93 is an effective inhibitor of CaMKII phosphorylating activity. It has been shown to induce cell cycle arrest in HeLa and NIH 3T3 cell fibroblasts. CAS # 139298-40-1

6
2-Amino-5-fluorobenzamidesc-335058 CAS # 63069-49-8

2-Bromoacetamidesc-237933 CAS # 683-57-8

clasto-Lactacystin β-Lactonesc-202105clasto-Lactacystin β-Lactone is the active species operative in lactacystin 20S proteasome inhibition. CAS # 154226-60-5

2
Andarinesc-364405Andarine stimulates AR-mediated transcription to 93% of that observed for 1 nM DHT at a concentration of 10 nM. CAS # 401900-40-1

4-iodo-SAHAsc-3643914-iodo-SAHA is an HDAC inhibitor. At 1 μM 4-iodo-SAHA demonstrates >60% inhibition of HDAC1 and HDAC6 activity in, similar to that of SAHA (sc-220139). CAS # 1219807-87-0

TG101348sc-364740TG-101348 (SAR302503) is a selective inhibitor of JAK2 with IC50 of 3 nM. CAS # 936091-26-8

Ceruleninsc-200827Cerulenin is an antibiotic and antifungal agent that potently and specifically inhibits Fatty Acid Synthase (FAS), and has been shown to induce apoptosis in a caspase dependent manner. CAS # 17397-89-6

Aerothioninsc-202446Bromotyrosine derivative with antimycobacterial activity. CAS # 28714-26-3

1
Heparin, Sodium Saltsc-203075Heparin, Sodium salt is a low molecular weight heparin (LMWH) polymer that produces its major anticoagulant effect by activating antithrombin CAS # 9041-08-1

2
2-Chloro-2',6'-acetoxylididesc-225263 CAS # 1131-01-7

Acetaminophensc-203425Acetaminophen is a Cox-1, Cox-2, and Cox-3 (cyclooxygenase) inhibitor. Acetaminophen may be selective for Cox-3. CAS # 103-90-2

A 61603 HYDROBROMIDEsc-203789Potent α-adrenoceptor agonist, at least 35-fold more potent at α1A than at α1B or α1D sites. CAS # 107756-30-9

BML-267sc-205605BML-267 is a potent and selective PTP1B (protein tyrosine phosphatase 1B) inhibitor (IC50=11 μM).

E-64-csc-201278E-64-c is an effective synthetic calpain inhibitor composed from E-64 (sc-201276), which also inhibits cathepsin B, cathepsin H, and cathepsin L (cysteine proteases). CAS # 76684-89-4

1
Bisindolylmaleimide IIIsc-221367Bisindolylmaleimide III is a potent and selective inhibitor of protein kinase C (PKC).

JAK2 Inhibitor IVsc-221774JAK2 Inhibitor IV is an aminoindazole compound that potently inhibits the activity of both the wild-type JAK2 and the constitutively active V617F mutant. JAK2 Inhibitor IV shows much reduced activity against JAK3.

ABT-888sc-202901ABT-888 has been shown to be a potent PARP (poly(ADP-ribose) polymerase) inhibitor which can result in apoptosis and suppression of cell growth. CAS # 912445-05-7

4
Hydroxyureasc-29061Hydroxyurea has been shown to induce apoptosis by inhibiting DNA synthesis via R1 and R2 (ribonucleotide reductase) inhibition; induces phosphorylation of FADD and p53. CAS # 127-07-1

10
KI 8751sc-203090KI 8751 is a selective inhibitor of Flk-1 (VEGFR-2) and c-Kit that has been shown to decrease cell proliferation and tumor growth. CAS # 228559-41-9

2-Chloroacetamidesc-237988 CAS # 79-07-2

Benazepril Free basesc-337551Benazepril Free base is an inhibitor of ACE (angiotensin-converting enzyme). CAS # 86541-75-5

4-P-PDOTsc-3610834-P-PDOT is a melatonin receptor antagonist, >300 times more selective for the MEL-1B-R over the MEL-1A-R subtype. CAS # 134865-74-0

Benazepril hydrochloridesc-203526Benazepril hydrochloride is an angiotensin-converting enzyme (ACE) inhibitor. This prevents the catalytic conversion of angiotensin I to angiotensin II and in turn causes vasodilation and an increase in capillary blood volume. CAS # 86541-74-4

Gambogic amidesc-221655Gambogic amide is a selective agonist for Trk A which mimics the actions of NGF.

2,2-Dibromo-2-cyanoacetamidesc-225555 CAS # 10222-01-2

(2R,3R)-Tartranilic Acid [for optical resolution]sc-288595 CAS # 3019-58-7

Lomustinesc-202697Lomustine possesses antitumor activity along with inhibitive activity towards glutathione reductase, lipoamide dehydrogenase and trypanothione reductase. It also activates p53 expression in A2870 cells. CAS # 13010-47-4

Apstatinsc-201309Apstatin is a selective inhibitor of Aminopeptidase P (APP), shown to increase Bradykinin-promoted cardioprotection by blocking APP degredation of Bradykinin. CAS # 160470-73-5

3-(4-Fluorophenyl)-2-propenamidesc-225868 CAS # 127406-78-4

DIPPA hydrochloridesc-221550DIPPA hydrochloride is an irreversible and selecitve κ-opioid receptor antagonist. CAS # 155512-52-0

3-Mercapto-N-nonylpropionamidesc-299074Organic thiol for SAMs.

IMD 0354sc-203084IMD 0354 is a cell-permeable salicylamide compound shown to act as a selective IKK beta (IKK-2) inhibitor by blocking IκBα phosphorylation and preventing induction of NF-κB p65 nuclear translocation. Found to reduce IL-1β and MCP-1 production in cardiac muscle cells and thus ac CAS # 978-62-1

3,5-Dinitrobenzamidesc-238702 CAS # 121-81-3

Raltegravirsc-364600Raltegravir is a potent HIV-1 integrase inhibitor. Raltegravir is active against HIV-2 in CEMx174 cells. Raltegravir efficiently inhibits SIVmac251 replication in acutely infected human lymphoid CD4+ T-cell lines MT-4 and CEMx174. CAS # 518048-05-0

4-(N-tert-Butoxycarbonylaminomethyl)benzyl alcoholsc-256648 CAS # 123986-64-1

Arphamenine Asc-201293Arphamenine A is an Aminopeptidase B inhibitor reported to also inhibit enkephalin-degrading. Arphamenine A decreases production of collagen, which results in the inhibition of lysyl oxidase. CAS # 144110-37-2

2
4-Amino-2,3,5,6-tetrafluorobenzamidesc-226471 CAS # 1548-74-9

N-(3-Indoleacetyl)glycinesc-257808 CAS # 13113-08-1

Octylonium Bromidesc-201035Octylonium Bromide has been reported to antagonize PAF induced aggregation of rabbit platelet-rich plasma. It demonstrates the ability to potently block neuronal nicotinic acetylcholine receptors. CAS # 26095-59-0

3
Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1sc-221711A cell-permeable thiazolyl benzamide compound that preferentially targets Hec1, disrupts Hec1/Nek2 complex, and destabilizes Nek2 leading to defective localization of Hec1 at kinetochores. Shown to induce transient mitotic arrest, and inhibit the proliferation of several breast cancer cells with a GI50 of 10 - 21 µM; further, reduce tumor outgrowth in a xenograft mouse model (50 mg/kg, i.p.).

Stat3 Inhibitor III, WP1066sc-203282Stat3 inhibitor III, WP1066 is a cell permeable inhibitor of STAT3, JAK2 protein tyrosine kinase and tumor cell growth. Also suggested to be an activator of Bax. CAS # 857064-38-1

9
ACPsc-221209This is a cell permeable probe for the detection of intracellular oxidative stress. ACP can easily be deprotected with esterases to cyclic hydroxylamines, which are oxidized by ROS which leads to ESR-detectable nitroxide radicals.

4-Aminobenzamidesc-254605 CAS # 2835-68-9

Caspase-1 Inhibitor IIsc-300323Caspase-1 Inhibitor II (Ac-YVAD-CMK), is a cell-permeable and irreversible inhibitor of caspase-1, caspase-4, and caspase-5. CAS # 178603-78-6

BML-210sc-221369BML-210 has been shown to inhibit HDAC activity in HeLa nuclear extracts (IC50 = 5-10μM). CAS # 537034-17-6

TAPI-2sc-205851TAPI-2 is an inhibitor of TACE, ADAMs, ACE secretase, and other MMP (metalloproteinases). Shown to block the release of a variety of targets including TNFα. CAS # 187034-31-7

4'-Acetamido-2'-methylacetophenonesc-254751 CAS # 34956-31-5

JX-401sc-200687JX-401 is a potent non-cytotoxic cell membrane permeable p38α inhibitor that acts by reversibly binding MAPK p38α. CAS # 349087-34-9

CGP 20712 Dihydrochloridesc-203879CGP 20712 Dihydrochloride is a highly potent and selective β1-AR adrenoreceptor antagonist. CAS # 1216905-73-5

T113242sc-222335T113242 is a cell-permeable pentafluorosulfonamide compound that induces microtubule depolymerization and cell-cycle arrest by irreversibly modifying β-Tubulin.

Novobiocin Sodium (U-6591)sc-358734Novobiocin Sodium (U-6591) is an inhibitor of DNA gyrase, DNA topoisomerase II, and Hsp90. CAS # 1476-53-5

GR 135531sc-203981GR 135531 is a putative melatonin MT3 receptor agonist, showing low affinity for melatonin receptors MEL-1A-R and MEL-1B-R in the hamster brain. CAS # 190277-13-5

4'-Chloroacetoacetanilidesc-223676 CAS # 101-92-8

Tunicamycinsc-3506Tunicamycin is a mixture of tunicamycins A, B, C and D which has been widely used in the study of glycoprotein synthesis in various biological systems. CAS # 11089-65-9

10
FTase Inhibitor IIsc-221633FTase Inhibitor II is a potent Farnesyl Transferase inhibitor that has been shown to prevent Ras activity. CAS # 156707-43-6

Exo1sc-200752Exo1 disrupts the functions of the Golgi apparatus by causing a fast collapse of the organelle by releasing ADP-ribosylation factor 1 (ARF1) from membranes of the Golgi. CAS # 461681-88-9

2
Amikacin disulfatesc-202457An aminoglycoside antibiotic that is active against gram- negative bacteria. It has similar activity to Gentamicin (sc-29066). CAS # 39831-55-5

MK2a Inhibitorsc-203138MK2a Inhibitor is a non-ATP-competitive p38α inhibitor CAS # 41179-33-3

4'-Hydroxybutyranilidesc-226864 CAS # 101-91-7

6-Methyl-2,4-pyrimidinediaminesc-300028 CAS # 179-73-7

Acetoacetamidesc-239184 CAS # 5977-14-0

Luzindolesc-202700Luzindole is a selective antagonist of the MEL-1B-R melatonin receptor. 25-fold higher affinity for MEL-1B-R over MEL-1A-R. Antagonizes melatonin inhibition of cyclic AMP release and dopamine release. Affects melatonin/MEL-1B-R-associated biological timing. CAS # 117946-91-5

3
MSK-195sc-202712Potent analgesic with EC50=0.96µg/kg in the acetic acid-induced writhing test. RTX binding affinity (Ki=603nM), agonism (calcium influx; EC50=240nM). CAS # 289902-82-5

5-Carboxamidotryptamine maleatesc-2034775-Carboxamidotryptamine maleate is a SR-1 agonist with high affinity at SR-1A, SR-1B, SR-1D, SR-5 and SR-7. CAS # 74885-09-9

Burimamide oxalatesc-203535Burimamide oxalate is a mixed Histamine H3 Receptor and Histamine H2 Receptor( H2/H3) antagonist. In SK-N-MC cells, this compound displays partial agonist activity. CAS # 34970-69-9

Aluminum dimethylamidesc-300187Used in the preparation of aluminum nitrides CAS # 32093-39-3

Benzanilidesc-254955Color Index: 42095 CAS # 93-98-1

MMP Inhibitor IIIsc-311427MMP Inhibitor III is a homophenylalanine-hydroxamic acid based broad-spectrum cell-permeable, reversible inhibitor of MMPs.

JTC 801sc-203614JTC 801 is a high affinity, selective NOP (KOR-3) receptor antagonist (Ki = 8.2 nM). Displays approximately 12.5-, 129- and 1055-fold selectivity over human μ-, κ- and δ-opioid receptors respectively. CAS # 244218-51-7

BH3I-2'sc-221355BH3I-2' is a cell-permeable BH3 mimetic that induces apoptosis by specifically preventing BH3 domain-mediated interaction between pro-apoptotic and anti-apoptotic members of the Bcl-2 family. CAS # 315195-18-7

Ebselensc-200740Ebselen is shown to inhibit 5-LO (5-lipoxygenase) and 15-LO (15-lipoxygenase). It also inhibits Cox (cyclooxygenase), PKC (protein kinase C), DECR1 (NADPH), and Mox-1 (NADPH oxidase). CAS # 60940-34-3

2
cis-13-Docosenoamidesc-227659 CAS # 112-84-5

MMP Inhibitor Vsc-203139MMP Inhibitor V, also called ONO-4817 is an orally active non-peptidyl hydroxamate compound that inhibits a broad range of metalloproteinases (MMP). CAS # 223472-31-9

AM 580sc-203505A selective retinoic acid analog, which is useful in vitro as a RARα agonist. This compound inhibits tumor proliferation, via reducing the level of RARγ. CAS # 102121-60-8

Cyclohexanecarboxamidesc-227701 CAS # 1122-56-1

4-Nitrophenyl-N-acetyl-β- D-glucosaminidesc-2814264-Nitrophenyl-N-acetyl-β- D-glucosaminide is a useful substrate for rapid colorimetric assay of N-acetyl-b-glucosaminidase activity in human urine. CAS # 3459-18-5

ITSA1sc-200894ITSA1 (N-(1H-Benzotriazol-1-yl)-2,4-dichlorobenzamide) is an HDAC activator via TSA suppression, but shows no activity towards other HDAC inhibitors. CAS # 200626-61-5

AF-DX 384sc-203498AF-DX 384 is a potent mAChR M2/mAChR M4 selective antagonist. CAS # 118290-27-0

Amisulpridesc-203510Amisulpride is a selective, potent D2DR and D3DR inhibitor. (Ki values are 2.8 and 3.2 nM respectively for human D2DR and D3DR and > 1000 nM for human D1DR, D4DR and D5DR.) CAS # 71675-85-9

DL-Panthenolsc-252763 CAS # 16485-10-2

MS-PPOHsc-205392MS-PPOH is a selective inhibitor of the epoxygenation reactions catalyzed by specific CYP450 isozymes. CAS # 206052-02-0

Picotamidesc-201334Picotamide is a dually active TXA2R (thromboxane A2) and TXA synthase (thromboxane A2 synthase) inhibitor. It has been shown to exhibit platelet inhibitory effects ex vivo and in vitro. CAS # 32828-81-2

Ethyl oxamatesc-239945 CAS # 617-36-7

MMP-2 Inhibitor IIsc-354092MMP-2 Inhibitor II is an oxirane analog of SB-3CT, pMS and reported to be an irreversible inhibitor of MMP-2 through active-site binding.

Ambenonium dichloridesc-203507Ambenonium dichloride, a selective rapidly reversible noncovalent inhibitor of AChE. Demonstrates high affinity at AChE (IC50 = 0.698 nM) and lower affinity at BChE (IC50 = 8.20 μM). CAS # 52022-31-8

Formanilidesc-235214 CAS # 103-70-8

Amplex Redsc-291898Amplex Red is a non-fluorescent and highly sensitive and stable hydrogen peroxide probe. CAS # 119171-73-2

MMP-2/MMP-3 Inhibitor Isc-295483MMP-2/MMP-3 Inhibitor I is a potent MMP-2 (gelatinase A; Ki = 17 µM) and MMP-3 (stromelysin-1; Ki = 290 nM) inhibitor.

D-erythro-Sphingosine, N-Oleoyl-sc-205936N-Oleoyl-D-erythro-sphingosine is a member of the ceramide family, acting as a signaling molecule with its function as a proapoptotic molecule among the most studied. CAS # 5966-28-9

Glycinamide hydrochloridesc-255189A buffer that is useful in the physiological pH range. CAS # 1668-10-6

Boc-Lys(Tfa)-AMCsc-300290A fluorogenic substrate for the assaying of histone deacetylase 4, 5 and 7 activity in a protease-coupled assay. CAS # 97885-44-4

N-(2-Dimethylaminoethyl)-N-methylformamidesc-255313 CAS # 105669-53-2

DL-PDMPsc-201391DL-PDMP is a ceramide analog first prepared in a search for inhibitors of UGCG (glucosylceramide synthase). CAS # 73257-80-4

1
N-(2,5-Dimethylphenyl)formamidesc-228632 CAS # 10113-40-3

MMP-2/MMP-9 Inhibitor IIsc-311430MMP-2/MMP-9 Inhibitor II is a potent inhibitor of MMP-2 and MMP-9. Also induces HIF activation and displays anticancer properties. CAS # 193807-60-2

GGTI-297sc-221672GGTI-297 is a potent, cell-permeable, and selective peptidomimetic inhibitor of GGTase I compared to Farnesyl Transferase (FTase).

SQ-29548sc-201332A compound that reversibly and competitively acts as a thromboxane A2/prostraglandin endoperoxide receptor antagonist. CAS # 98672-91-4

CTPBsc-202558A membrane-impermeable amide derivative that is an activator of p300 histone acetyltransferase activity. Shown to enhance p300 HAT-dependent transcriptional activation. CAS # 586976-24-1

DL-PPMPsc-205655This compound inhibits glucosylceramide synthetase and is more effective than PDMP in intact cells. CAS # 149022-18-4

N-(4-Hydroxyphenyl)stearamidesc-228637 CAS # 103-99-1

MMP-2/MMP-9 Inhibitor Vsc-354093MMP-2/MMP-9 Inhibitor V is a cell-permeable SB-3CT (sc-205847) sulfonamido analog that selectively inhibits MMP-2 and MMP-9.

N-(4-Iodo-3-nitrophenyl)acetamidesc-301215

N-2-(Bromophenyl)formamidesc-228656 CAS # 10113-38-9

Smoothened Agonist, HClsc-202814Smoothened Agonist, HCl is a highly potent activator of Smo and a Hedgehog pathway agonist from the chlorobenzothiophene family. CAS # 364590-63-6

10
Devazepidesc-203562Devazepide is a non-peptide CCK (cholecystokinin) receptor antagonist. It has been shown to induce apoptosis and inhibit cell proliferation. CAS # 103420-77-5

N-Acetylprocainamide hydrochloridesc-253092Class III antiarrhythmic. This compound Increases the duration of the action potential by decreasing the delayed outward potassium current, slightly decreasing the calcium current, and slightly depressing the inward rectifier potassium current. This is the active metabolite of procainamide that does not induce systemic lupus erythematosus. CAS # 34118-92-8

M 344sc-203124M344 is a potent HDAC inhibitor with IC50 of 100 nM. CAS # 251456-60-7

8
N-Methylformamidesc-250476 CAS # 123-39-7

Nimesulidesc-200623Nimesulide is an anti-inflammatory Cox inhibitor, with selectivity for Cox-2 over Cox-1. CAS # 51803-78-2

ICA 069673sc-362745ICA 069673 is a potassium channel opener with selective action for KCNQ2 and KCNQ3 (EC50=0.69 μM). CAS # 582323-16-8

N-Acetyl-S-geranyl-L-cysteine (AGC)sc-221983N-Acetyl-S-geranyl-L-cysteine (AGC) is a close structural analog of AFC and AGGC but is biologically inactive.

Actinoninsc-201289Actinonin is an antibiotic shown to inhibit aminopeptidases, PDF (peptide deformylase), meprin A, CD 13 and MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-12 and MMP-13. CAS # 13434-13-4

N-Methylformanilidesc-250477 CAS # 93-61-8

LOE 908 hydrochloridesc-204060Broad spectrum cation channel blocker; neuroprotective CAS # 149759-26-2 (anhydrous)

N-Methylpropionamidesc-250480 CAS # 1187-58-2

N-(4-Hydroxyphenylpropanoyl) spermine trihydrochloridesc-204109Wasp toxin analog. More potent than PhTX-343 at locust NMJ. Antagonist of the quisqualate-sensitive L-glutamate receptor (quis-GluR) of locust muscle. CAS # 130631-59-3

PD 174265sc-204170PD 174265 is a potent, cell-permeable, reversible, and selective inhibitor of EGFR (EGF receptor) tyrosine kinase activity (IC50 = 450 pM). CAS # 216163-53-0

N-Methyltrifluoroacetamidesc-250482 CAS # 815-06-5

N,N-Dibutylformamidesc-250498 CAS # 761-65-9

N,N-Diethyl-2-(1-naphthyloxy)propanamidesc-250501 CAS # 15299-99-7

N,N-Diethylacetoacetamidesc-357395 CAS # 2235-46-3

IRL-2500sc-204018Potent, selective ET(B) antagonist. CAS # 169545-27-1

Nullscriptsc-222084Nullscript is a negative control compound for the HDAC (histone deacetylase) inhibitor Scriptaid (sc-202807). CAS # 300816-11-9

N,N-Diethylformamidesc-250506 CAS # 617-84-5

MMP-9/MMP-13 Inhibitor Isc-311438MMP-9/MMP-13 Inhibitor I is a piperazine-based, cell-permeable, and highly potent inhibitor of MMP-9 and MMP-13. CAS # 204140-01-2

DICAsc-202135DICA is an inhibitor of caspase-3 and caspase-7 binding to an allosteric site and not to the active site. CAS # 613665-26-2

Lignoceric ceramidesc-202694Naturally occurring ceramide and integral part of the sphingomyelin cycle. Lignoceric ceramide stimulates the proliferation of basophilic erythroblasts, suggesting a possible role in erythrocyte maturation. CAS # 34435-05-7

Oxamflatinsc-205960Oxamflatin is a potent inhibitor of mammalian HDAC. Oxamflatin acts as a ligand for the enzyme active site metal ion. CAS # 151720-43-3

N,N-Diethylpropionamidesc-228759 CAS # 1114-51-8

NF 023sc-204124NF 023 is a subtype selective, competitive and reversible P2X1 receptor antagonist (IC50 = 0.21μM). CAS # 104869-31-0

NNGHsc-222075NNGH, MMP-3 Inhibitor II, is a demonstrated cell-permeable and potent inhibitor of human MMP-3. CAS # 161314-17-6

N,N-Diisopropylformamidesc-250511 CAS # 2700-30-3

N,N-Dimethyl-2-chloroacetoacetamidesc-250512 CAS # 5810-11-7

SD-169sc-200693SD-169 is a compound that inhibits p38α and p38β MAPK and acts as an ATP competitive inhibitor of p38 kinase. CAS # 1670-87-7

NF 110sc-203642NF 110 is a potent antagonist of the P2X3 receptor subtype. This compound displays anti-tumor activity against several tumor cell types. CAS # 111150-22-2

N,N-Dimethylacetoacetamide solutionsc-250515 CAS # 2044-64-6

Formoterol Fumaratesc-203050Formoterol Fumarate has been shown to be a potent agonist of β-AR adrenoceptor with selectivity for β2-AR than β1-AR receptors. CAS # 43229-80-7

N,N-Dimethylacrylamidesc-255370 CAS # 2680-03-7

3-O-Methyl-N-acetyl-D-glucosaminesc-2028863-O-Methyl-N-acetyl-D-glucosamine is shown to inhibit GlcNAc kinase and GLCNE, without inhibiting glucokinase - potentially useful for accurate assay of glucokinase activity in pancreatic islets and liver tissues. CAS # 94825-74-8

2
N,N-Dimethylmethacrylamidesc-363736 CAS # 6976-91-6

WZ 4002sc-364655WZ 4002 is a potent and selective EGFR inhibitor that blocks signal transduction at the cell surface, leading to apoptosis. CAS # 1213269-23-8

Cefaclorsc-202532A cephalosporin antibiotic that inhibits cell wall synthesis and is active against a wide spectrum of common pathogens, including gram-positive and gram-negative bacteria. CAS # 53994-73-3

L-692,585sc-204043L-692,585 is a potent, non-peptidyl growth hormone receptor (GHS-R1a) agonist with a Ki value of 0.8 nM. L-692,585 increases the plasma growth hormone levels in vivo CAS # 145455-35-2

N,N-Diphenylformamidesc-250527 CAS # 607-00-1

N-SMase Spiroepoxide Inhibitorsc-202721Potent and selective irreversible inhibitor of neutral sphingomyelinase (N-SMase). CAS # 282108-77-4

Guanfacine hydrochloridesc-203988Guanfacine hydrochloride is an anti-hypertensive agent that has been shown to be a specific α2A-AR adrenoceptor agonist. CAS # 29110-48-3

Dihydrocapsaicinsc-202578Dihydrocapsaicin is isolated from Capsicum fruit. Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Like capsaicin, dihydrocapsaicin is an irritant. Capsaicin is found in natural hot pepper extracts along with a number of impurities, including dihydrocapsaicin and several lesser impurities. Separation by HPLC is required in order to obtain pure dihydrocapsaicin. Dihydrocapsaicin represents about 10% of the compound present in commercial preparations purporting to be pure capsaicin, but it has about the same pungency as capsaicin. VR1 (vanilloid receptor 1) is a heat activated calcium ion channel which functions as a part of the normal nociceptive pain pathway. Capsaicin elicits a sensation of burning pain by activation of VR1 on small, non-myelinated polymodal C-type nociceptive nerve fibers. The potency of dihydrocapsaicin at VR1 appears equivalent to capsaicin. Antioxidant. Reduces oxidation of serum lipids. Mutagenic. CAS # 19408-84-5

N,N'-Diallyl L-tartardiamidesc-257883 CAS # 58477-85-3

(-)-N,N'-Dibenzyl-D-tartaric diamidesc-224159 CAS # 108321-43-3

Nervonic ceramidesc-202729Naturally occurring ceramide and integral part of the sphingomyelin cycle. Nervonic ceramide stimulates the proliferation of basophilic erythroblasts, suggesting a possible role in erythrocyte maturation. CAS # 54164-50-0

Naphthol AS-D acetatesc-250551 CAS # 528-66-5

Tenovin-1sc-222342Tenovin-1 is a compound that belongs to the class of Tenovins, and inhibits SIRT1 and SIRT2. CAS # 380315-80-0

L-817,818sc-204048A potent and selective non-peptide somatostatin subtype-5 receptor agonist. CAS # 217480-27-8

(S)-(+)-2,2-Dimethylcyclopropanecarboxamidesc-255570This is used in the preparation of (Z)-2-(acylamino)-3-substituted propenoic acids as inhibitors of the mammalian β-lactamase renal dipeptidase. CAS # 75885-58-4

Lidocaine hydrochloride hydratesc-202211Na+ channel blocker CAS # 6108-05-0

Succinamidesc-251074 CAS # 110-14-5

Trichloroacetamidesc-251306 CAS # 594-65-0

Trifluoroacetamidesc-251333 CAS # 354-38-1

NOR-4sc-202739A NO donor compound with a half-life NO release of 340 minutes. CAS # 163180-50-5

4-[(1-oxo-7-phenylheptyl)amino]-(4R)-octanoic acidsc-2236024-[(1-oxo-7-phenylheptyl)amino]-(4R)-octanoic acid a simple amide based on (R)-α-norleucine, is a selective and potent inhibitor of sPLA2. CAS # 1101136-50-8

PTP CD45 Inhibitorsc-222223PTP CD45 Inhibitor is a cell-permeable, potent, selective, competitive, and reversible inhibitor of CD45. CAS # 345630-40-2

Trichostatin Asc-3511Trichostatin A (TSA) inhibits HDAC, blocks the cell cycle at G1, induces reversion of Ras transformed cells to normal morphology, and inhibits IL-2 expression in Jurkat cells. CAS # 58880-19-6

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NGB 2904sc-204127NGB 2904 is a highly-selective D3DR antagonist, with antagonistic effects against quinpirole-stimulated mitogenesis. CAS # 189060-98-8

MEGA-8sc-280957MEGA-8 is a water-soluble detergent with nondenaturing properties. Can be readily removed by dialysis. MEGA 8 is also a useful reagent for membrane research. CAS # 85316-98-9

QX-314sc-3579QX-314 is a quarternary lidocaine (sc-204056) derivative which acts as a local anesthetic and a strong sodium channel protein inhibitor of intracellular voltage-sensitive sodium ion conductance. CAS # 21306-56-9

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JTE 907sc-203616JTE 907 is a highly selective cannabinoid CB2 receptor inverse agonist. JTE 907 binds with high affinity to rat, mouse and human CB2 receptors. CAS # 282089-49-0

Streptozotocin (U-9889)sc-200719A potent DNA methylating small molecule, particularly active in pancreatic cells. CAS # 18883-66-4

MCI-186sc-200806MCI-186 is a free radical scavenger with protective properties towards murine neuronal ischemia. Found to enhance NGF protein levels via the JNK pathway. CAS # 89-25-8

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SR 49059sc-204300SR 49059 is a potent, selective, non-peptide, orally active AVP Receptor V1a (Vasopressin V1a) antagonist. CAS # 150375-75-0

PknG Inhibitorsc-222180PknG Inhibitor is a cell-permeable tetrahydrobenzothiophene compound that acts as a highly specific and ATP-binding site-targeting inhibitor against mycobacterial protein kinase G (PknG; IC50 = 390 nM). CAS # 329221-38-7

Remoxipride Hydrochloridesc-200410Remoxipride, a substituted benzamide, is an atypical antipsychotic agent, as well as, a selective and potent D2DR agonist. CAS # 73220-03-8

N-Acetylneuraminic Acid, 2,3-Dehydro-2-deoxy-, Sodium Saltsc-221987N-Acetylneuraminic Acid, 2,3-Dehydro-2-deoxy-, Sodium Salt is an inhibitor of bacterial, viral, and mammalian neuraminidases (KI = 4 μM for influenza virus neuraminidase). CAS # 24967-27-9

Enniatin Bsc-202150An ionophore antibiotic that inhibits Pdr5p. Studies indicate that it has cytotoxic activity in vitro and no genotoxic activity. CAS # 917-13-5

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KN-92sc-311369K-92 is the inactive form of KN-93.

Palmitoylethanolamidesc-202754Palmitoylethanolamide is an endogenous cannabinoid. It is a weak ligand of the cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptors. It also acts as a selective activator of the GPR55 receptor and inhibits FAAH. This product binds to PPARα, producing an anti-inflammatory response CAS # 544-31-0

Lipoprotein Lipase Activatorsc-204059Lipoprotein Lipase Activator is a cell-permeable benzylphosphonate derivative that selectively induces lipoprotein lipase (LPL) mRNA and protein levels, but does not exhibit PPARα or PPARγ agonistic activities. CAS # 133208-93-2

SU1498sc-355982SU1498 is a potent ATP-competitive and selective inhibitor of Flk-1 (Flk-1 kinase), a vascular endothelial growth factor (VEGF) receptor kinase. Able to reduce expression of ets-1.

Nimustine hydrochloridesc-202732DNA alkylator and cross-linker. Anticancer agent used to treat malignant glioma. Cardiovascular teratogenicity was studied in rat fetuses. CAS # 55661-38-6

AAF-CMKsc-205591AAF-CMK is a serine protease inhibitor which irreversibly inhibits TPPII (tripeptidyl peptidase II), a giant protease which may substitute for some proteasome functions1, and reversibly inhibits Cln2 (TPPI). CAS # 184901-82-4

Amidepsine Asc-221244This is an inhibitor of diacylglycerol acyltransferase (DGAT). This shows inhibitory effect in rat liver microsomes (IC50=10.2µM) and Raji cells (IC50=15.5µM). It has excessive accumulation of triacetylglycerol produced by DGAT which may cause fatty liver, obesity and hypertriglyceridemia, and may lead to atherosclerosis, diabetes and metabolic disorders. CAS # 169181-28-6

Lazabemide hydrochloridesc-202208Lazabemide hydrochloride is known to be a reversible and selective inhibitor of monoamine oxidase-B. This compound has been shown to also display antioxidant activity. CAS # 103878-83-7

Sodium taurocholatesc-281163Sodium taurocholate is a detergent useful for the solubilization of lipids and membrane-bound proteins. Aggregation number 4. CMC 3–11 mM. Micellar weight 2100. pKa 1.9. CAS # 145-42-6

Taurodeoxycholic Acid, Sodium Saltsc-281164Taurodeoxycholic Acid, Sodium Salt is a detergent useful for the solubilization of lipids and membrane-bound proteins. Aggregation number: 6. CMC 1 - 4 mM. pKa 1.9. CAS # 1180-95-6

LP 44sc-224044LP 44 is a high affinity SR-7 agonist. CAS # 824958-12-5

AK-7sc-364096AK-7 is an inhibitor of SIRT2. CAS # 420831-40-9

ABD-Fsc-205925ABD-F is a highly reactive fluorogenic reagent for labelling thiol compounds. Selectively labels protein cysteine residues without side chain modification or N-terminal blockage. CAS # 91366-65-3

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β-Catenin/Tcf Inhibitor, FH535sc-221398β-Catenin/Tcf Inhibitor, FH535 is a sulfonamide-based and cell-permeable compound that exhibits a dual pathway inhibition against Wnt/β-catenin and PPAR. CAS # 108409-83-2

Cdk2/5 Inhibitorsc-221410Cdk2/5 Inhibitor is an aminopyrimidine derivative that acts as a selective and ATP-competitive inhibitor of Cdk2/cyclin E and Cdk5/p25. Cdk2/5 Inhibitor binds to the ATP-binding pocket of Cdk2.

Cyclapolin 9sc-205279Cyclapolin 9 is a selective and ATP-competitive polo-like kinase (Plk) inhibitor. Plks are known to be involved with cell cycle regulation, mitosis, cytokinesis, and the DNA damage response. CAS # 40533-25-3

Neoantimycinsc-202240A macrocyclic antibiotic isolated from Streptomyces strains. CAS # 22862-63-1

Oleamidesc-358696Oleamide acts as an agonist at the CB1 cannabinoid receptor. Oleamide also appears to potentiate the actions of 5-HT on 5-HT2A and 2C receptors. CAS # 301-02-0

BML-277sc-200700BML-277 is a Chk2 (checkpoint kinase 2) inhibitor. BML-277 protects T cells from apoptosis by controlling the response of p53 to radiation-induced DNA breaks. CAS # 516480-79-8

Geldanamycinsc-200617Geldanamycin binds specifically to Hsp90 and inhibits it by down-regulating target proteins including tyrosine kinases, steroid receptors, and transcription factors. CAS # 30562-34-6

P-Glycoprotein Inhibitor, C-4sc-222109P-Glycoprotein Inhibitor, C-4 is a cell-permeable cinnamoyl compound that inhibits Mdr-1 (P-gp). This in turn inhibits cellular efflux of active compounds, effectively reversing multidrug resistance in cells.

Cathepsin/Subtilisin Inhibitorsc-221400Cathepsin/Subtilisin Inhibitor inhibits members of the cysteine protease family including cathepsin L,

cFMS Receptor Inhibitor IIIsc-221416A cell-permeable anilinoquinoline compound that acts as a strong, active site-targeting inhibitor of MCSF receptor/cFMS. This compound is 100-fold more potent in inhibiting the cFMS-dependent growth of M-NSF-60 cells than the cFMS-independent growth of NSO cells. CAS # 959861-21-3

Collagenase Inhibitor Isc-221432Collagenase Inhibitor I is a potent and specific inhibitor of vertebrate MMP (collagenases) with values in the micromolar range. CAS # 123984-15-6

Leflunomidesc-202209Leflunomide is an inhibitor of Cox-2, of tyrosine phosphorylation (tyrosine kinase inhibitor), of dihydroorotate dehydrogenase, and of TNF-dependent NF-κB activation. CAS # 75706-12-6

Cyclothiazidesc-202560Cyclothiazide potently inhibits the desensitization of AMPA receptors. CAS # 2259-96-3

γ-Secretase Inhibitor XXI, Compound Esc-222308γ-Secretase Inhibitor XXI, Compound E is a cell-permeable, potent, selective, peptidomimetic, non-transition-state analog inhibitor of γ-secretase and Notch processing.

Darrow Redsc-214857Darrow Red is used for staining neuron cell bodies in paraffin or frozen samples of formalin fixed spinal cord or brain. CAS # 15391-59-0 (non-salt)

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Foroxymithinesc-202159A potent chelator of the ferrous ion and specific inhibitor of angiotens.in I converting enzyme at an IC50 of 7μg/ml CAS # 100157-28-6

Stem-Cell Factor/c-Kit Inhibitor, ISCK03sc-355981Stem-Cell Factor/c-Kit Inhibitor, ISCK03 is a cell-permeable phenyl-imidazolosulfonamide compound that inhibits c-kit activity CAS # 945526-43-2

N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamidesc-203441A pro-drug of the potent vasorelaxant nitroxyl, H-N=O, which it slowly releases in neutral solution. HNO eventually dimerizes and dehydrates to N2O, without producing NO. CAS # 142867-52-5

JNJ 303sc-361217JNJ 303 is a potent IKs blocker that does not display effects on other cardiac channels. CAS # 878489-28-2

LY2183240sc-200357LY2183240 is a potent inhibitor of FAAH activity, and the uptake and enzymatic hydrolysis of anandamide (sc-205592). CAS # 874902-19-9

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Phalloidin, Coumarin Labeledsc-301532This product is a fluorescent phallotoxin which can be used to identify filamentous actin.

Monoacylglycerol Lipase Inhibitor, URB602sc-203141Cell-permeable N-biphenyl carbamate that acts as a selective and non-competitive inhibitor of monoacylglycerol lipase. CAS # 565460-15-3

N-Arachidonyl maleimidesc-205760N-Arachidonyl maleimide is a highly potent and irreversible inhibitor of Monoglyceride Lipase (MAG lipase) which covalently binds to a cysteine residue located near the fatty acid binding site. CAS # 876305-42-9

N-Oxalylglycinesc-202720A cell permeable α-ketoglutarate analogue that functions as a competitive inhibitor of prolyl 4-hydroxylase which hydroxylates proline-rich peptides in vitro. CAS # 5262-39-5

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ThioFluor 623sc-205524ThioFluor 623 cell-permeable, rapid, selective, and fluorescent thiol-reactive probe. CAS # 1004324-99-5

N-(3-Fluoranthyl)maleimidesc-215415N-(3-Fluoranthyl)maleimide is used as a fluorescent protein marker. CAS # 60354-76-9

P32/98sc-201305P32/98 is a specific, competitive transition-state substrate analog inhibitor of CD26 (dipeptidyl peptidase IV, DPPIV). CAS # 136259-20-6

Probenecidsc-202773Probenecid is an inhibitor of MRP1 (multidrug resistance-associated proteins) and prevents cellular efflux of other active compounds. CAS # 57-66-9

N-Methyl-d3-2-pyrrolidinone-d6sc-301375 CAS # 185964-60-7

SB366791sc-364136SB366791 is a selective and competitive VR1 (TRPV1) antagonist that is commonly used in pain research. CAS # 472981-92-3

γ-Secretase Inhibitor VIIsc-301797γ-Secretase Inhibitor VII is a cell-permeable reversible inhibitor of Aβ and p3 secretion (Aβ40 IC50 = 2.3 μM; Aβ42 IC50 = 3 μM).

NP-LLL-VSsc-222078NP-LLL-VS is an intermediate that can be used to prepare radiolabeled 125I-NIP-L3VS for proteasome inhibition studies.

Ganglioside GD1a disodium salt (bovine brain)sc-202621Differentiation marker for cell growth. Protein kinase C (PKC) inhibitor. The major ganglioside of the nervous system. CAS # 12707-58-3

Ganglioside GD2, Disialo, Human Brainsc-204761Ganglioside GD2, Disialo, Human Brain serving as a useful marker of various cell types and antigens. CAS # 65988-71-8

Ganglioside GM3 sodium salt (bovine brain)sc-202628The major ganglioside of the extra-nervous system. Inhibits growth of epidermal cells. CAS # 54827-14-4

1-Benzyl-3-(trifluoroacetamido)pyrrolidinesc-297775 CAS # 115445-23-3

1,3-Dimethyl-5-pyrazolonesc-351999 CAS # 2749-59-9

2-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1H-1,3-benzodiazol-1-yl]-N-(2-butoxyphenyl)acetamidesc-298202

2-amino-N-(4-bromophenyl)acetamide hydrochloridesc-341353

3-Amino-N,N-dimethyl-propionamidesc-312470 CAS # 1857-18-7

3-Aminobenzanilidesc-280347 CAS # 16091-26-2

[(3-Chlorobenzoyl)amino]acetic acidsc-276182 CAS # 57728-59-3

4-[(2-Bromoacetyl)amino]-N-isopropylbenzamidesc-315075

4-[(4-methoxybenzoyl)amino]butanoic acidsc-348627 CAS # 72432-14-5

4-Amino-N-(2,6-dimethylphenyl)benzamidesc-315853 CAS # 787-93-9

4-amino-N-[(butylamino)carbonyl]benzenesulfonamidesc-349164 CAS # 339-43-5

Ac-Lys-AMC (Acetate salt)sc-300154 CAS # 156661-42-6

D(-)-Phenylglycinamidesc-357327 CAS # 6485-67-2

J 113863sc-203611Potent CCR1 chemokine receptor antagonist. Displays high selectivity for human, but not mouse, CCR3 receptors. In mice, improves paw inflammation, joint damage, and greatly reduces cell infiltration into joints in collagen-induced arthritis. CAS # 353791-85-2

N-[4-(2-Bromo-ethoxy)-phenyl]-acetamidesc-330881 CAS # 57011-90-2

N-Ethyl-3-(ethylamino)propanamidesc-331290

N-Methyl-3-[(3-pyridinylmethyl)amino]propanamidesc-331379

N,N-dimethyl-2-[(2,2,2-trifluoroethyl)amino]acetamidesc-355828

N,N'-p-Phenylenebisacetamidesc-269937 CAS # 140-50-1

Potassium (4-Cbz-aminophenyl)trifluoroboratesc-301566 CAS # 850623-45-9

Tetracyclinesc-237026 CAS # 305833-60-7

Thyroid Hormone Receptor Antagonist, 1-850sc-222357Thyroid Hormone Receptor Antagonist, 1-850 is a cell-permeable hydrazinyl-carboxamide compound which acts as a selective and high-affinity Thyroid Receptor (thyroid hormone receptor) antagonist.