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Akt3 Inhibitors

We now offer a broad range of Akt3 Inhibitors. The serine/threonine kinase Akt family contains several members, including Akt1 (also designated PKB or RacPK), Akt2 (also designated PKBβ or RacPK-β) and Akt 3 (also designated PKBγ or thyoma viral proto-oncogene 3). Akt3 is expressed in 3T3-L1 fibroblasts, adipocytes and skeletal muscle and may be involved in various biological processes, including adipocyte and muscle differentiation, glycogen synthesis, glucose uptake, apoptosis and cellular proliferation. Akt3 Inhibitors offered by Santa Cruz inhibit Akt3 and, in some cases, other glycogen synthesis and cellular proliferation related proteins. View detailed Akt3 Inhibitor specifications, including Akt3 Inhibitor CAS number, molecular weight, molecular formula and chemical structure, by linking to the specific product blocks.

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For functional analysis of Akt3 Inhibitors, see our complete listing of Akt3 Antibodies.


PRODUCT NAMECATALOG #DESCRIPTIONCITATIONSRANKING
MK-2206 dihydrochloridesc-364537MK-2206 is a highly selective pan-Akt inhibitor (IC50’s: Akt1 = 8 nM, Akt2 = 12 nM, and Akt3 = 65 nM). MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. CAS # 1032350-13-2

Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2sc-221231Akt Inhibitor XIII, Isozyme-Selective, Akt1/2 inhibitor is a highly cell-permeable and water soluble analog of Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (sc-202048).

GSK 690693sc-363280GSK 690693 is an ATP-competitive pan-Akt kinase inhibitor. GSK 690693 has been shown to producte antiproliferative and apoptotic effects in tumor cell lines. CAS # 937174-76-0

Triciribinesc-200661Triciribine (also: API-2) is known to suppress the phosphorylation level and kinase activity of Akt. Selectively inhibits Akt1, Akt2, and Akt3 without inhibiting known upstream activators, PDK1 and PI 3-Kinase, of Akt. CAS # 35943-35-2