| | Activators - Other
- 1,1-Dimethylbiguanide, Hydrochloride
An antihyperglycemic biguanide that lowers blood glucose levels without stimulating insulin secretion, promoting weight gain or causing hypoglycemia.| Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-202000 | 1115-70-4 | C4H11N5 ·HCl | 1 g/5 g |
- 8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-cyclic Monophosphate sodium salt
A cell-permeable potent activator of the Epac cAMP receptor, that does not affect PKA, making this potentially useful to discriminate between Epac and PKA-mediated effects.| Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-202028 | 510774-50-2 | C17H16CIN5O6PS ·Na | 1 mg/5 mg |
- 12-Deoxyphorbo 13-Angelate 20-Acetate
Weak tumor promoter (mouse skin), but moderately strong irritant| Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-287294 | 25090-72-6 | C27H36O7 | 1 mg |
- A 769662
An AMP-activated protein kinase (AMPK) activator that mimics the function of AMP on AMPK β-1 by allosteric activation and the inhibition of dephosphorylation of AMPK.| Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-203790 | 844499-71-4 | C20H12N2O3S | 10 mg/50 mg |
- Adenosine 3′,5′-cyclic Monophosphorothioate,8-Bromo-, Sp-Isomer,Sodium Salt
A potent cell-permeable, metabolically-stable activator of cAMP-dependent protein kinase (PKA).| Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-221215 | N/A | C10H10BrN5O5PS ·Na | 5 µmol |
- AICA-Riboside, 5′-Phosphate
A monophosphorylated analog of the membrane permeable AICA-Riboside that activates AMPK.| Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-202448 | 3031-94-5 | C9H15N4O8P | 50 mg |
- AM 580
A selective retinoic acid analog, which is useful in vitro as a RARα agonist. This compound inhibits tumor proliferation, via reducing the level of RARγ.| Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-203505 | 102121-60-8 | C22H25NO3 | 5 mg/25 mg |
- AMPK Activator
AMP-activated protein kinase (AMPK) Activator is a furancarboxylic acid derivative that can permeate the cell and partially inhibit the mitochondrial complex I.| Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-203819 | 849727-81-7 | C22H21FO4 | 5 mg |
- CD 1530
Potent and selective RARg agonist| Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-203871 | 107430-66-0 | C27H26O3•xH2O | 10 mg/50 mg |
- CD 3254
A selective RXRα agonist which is reported to not exhibit activity at RARα. RARβ or RARγ receptors.| Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-358786 | 196961-43-0 | C24H28O3•xH2O | 10 mg/50 mg |
- CH 55
A highly potent, synthetic retinoid that has high affinity for RAR-α and RAR-β receptors and low affinity for cellular retinoic acid binding protein (CRABP).| Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-203884 | 110368-33-7 | C24H28O3 | 10 mg/50 mg |
- CITCO
Cell-permeable imidazothiazole compound. Potent and selective agonist for the human orphan nuclear constitutive androstane receptor (CAR). | Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-202544 | 338404-52-7 | C19H12Cl3N3OS | 5 mg |
- Cord Factor
Immunomodulatory compound. Induces activation of macrophages independent of TLR2 or TLR4.| Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-202555 | 61512-20-7 | N/A | 1 mg |
- CTPB
A membrane-impermeable amide derivative that is an activator of p300 histone acetyltransferase activity. Shown to enhance p300 HAT-dependent transcriptional activation.| Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-202558 | 586976-24-1 | C31H43ClF3NO2 | 1 mg/5 mg |
- Glucocorticoid Receptor Modulator, CpdA
A cell-permeable aziridine precursor that acts as a nonsteroidal glucocorticoid receptor ligand with a binding affinity that is 4-fold higher than that of Dexamethasone. | Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-221677 | N/A | C11H14ClNO2 ·HCl | 25 mg |
- Guanosine 5'-O-(3-thiotriphosphate) tetralithium salt
G-protein-activating GTP analog; more resistant to hydrolysis than GTP. Induces exocytosis in isolated mouse pancreatic acinar cells. Also reported to stimulate insulin release from pancreatic β-cells| Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-202639 | 94825-44-2 | C10H12N5O13P3S ·4Li | 10 mg |
- Guanosine-3′,5′-cyclic Monophosphate, 8-(2-Aminophenylthio)-Sodium Salt
Isozyme-selective activator of cGMP-dependent protein kinase 1a.| Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-203335 | 144509-87-5 | C16H16N6O7PS ·Na | 5 µmol |
- IBC 293
A cell permeable Niacin triazolo derivative that is a selective agonist towards the human orphan G-protein-coupled receptor GPR109b/HM74.| Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-203079 | 306935-41-1 | C10H11N3O2 | 25 mg |
- ITE
| Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-361214 | 448906-42-1 | C14H10N2O3S | 10 mg |
- Kahweol acetate
Inducer of glutathione S-transferase. | Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-228383 | 81760-47-6 | C22H28O4 | 10 mg/25 mg |
- L-JNKi 1 trifluoroacetate salt
| Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-300882 | N/A | C164H286N66O40•xC2HF3O2 | 1 mg |
- m-3M3FBS
Shown to stimulate calcium concentration increase in neutrophils by direct activation of PLC. Also has been reported to up-regulate Bax, down-regulate Bcl-2, and release Cytochrome c.| Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-202217 | 200933-14-8 | C16H16F3NO2S | 10 mg |
- Methyl α-Bromo-2-chlorophenylacetate
| Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-207877 | 85259-19-4 | C9H8BrClO2 | 250 mg |
- Monosodium urate (crystals)
A cell permeable inflammatory compound that engages caspase-1-activiating cryopyrin inflammasome leading to the production of IL-1β and IL-18.| Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-202711 | 1198-77-2 | C5H3N4O3•Na | 2 mg |
- N-[3-(2-Furyl)acryloyl]-Leu-Gly-Pro-Ala
| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-253087 | 78832-65-2 | C23H32N4O7 | 5 mg/25 mg |
- N-Hippuryl-His-Leu hydrate
Isolation of human liver angiotensin-converting enzyme by chromatofocusing.| Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-253112 | 207386-83-2 | C21H27N5O5•xH2O | 250 mg |
- Naphthol AS-TR phosphate disodium salt
Substrate for the histochemical demonstration of acid and alkaline phosphatase.| Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-253179 | 4264-93-1 | C18H13ClNNa2O5P | 100 mg/1 g |
- O-3M3FBS
Inactive analog of m-3M3FBS . Used as a negative control.| Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-204142 | 313981-55-4 | C16H16F3NO2S | 10 mg |
- S-(5'-Adenosyl)-L-methionine chloride
Methyl donor; cofactor for enzyme-catalyzed methylations, including DNA methyltransferases (DNMT) and catechol O-methyltransferase (COMT).| Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-253444 | 24346-00-7 | C15H23ClN6O5S | 5 mg/25 mg |
- S-Benzyl-L-cysteine p-nitroanilide
A substrate used for the assay of cystyl-aminopeptidase (oxytocinase), EC 3.4.11.3.| Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-253447 | 7436-62-6 | C16H17N3O3S | 100 mg |
- SEW2871
A selective agonist of EDG-1 (Sphingosine-1-phosphate receptor 1; S1P1). Useful tool for elucidating the cardiovascular regulatory behaviors of EDG-1.| Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-203251 | 256414-75-2 | C20H10F6N2OS | 5 mg/10 mg |
- Scoparone
A compound found in the herb, Yin Chin, that can up-regulate the expression and activate the constitutive androstane receptor (CAR) found in the liver.| Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-202806 | 120-08-1 | C11H10O4 | 25 mg |
- SIRT1 Activator 3
An activator of the enzyme SIRT1 that increases fluorescence by 233% in a SIRT1 activity assay, regulates the activity of the p53 tumor suppressor to inhibit apoptosis, and has shown activity in fat mobilization of adipocyte cells.| Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-222315 | 839699-72-8 | C20H25N5O2 | 1 mg/5 mg |
- T 0901317
A nonsterol, cell-permeable benzenesulfonamide compound, that acts as a highly potent and selective agonist of the liver X receptor.| Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-202824 | 293754-55-9 | C17H12NSO3F9 | 10 mg |
- TCPOBOP
The most potent known member of the phenobarbital-like class of cytochrome P450 (CYP)-inducing agents.| Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-203291 | 76150-91-9 | C16H8Cl4N2O2 | 25 mg |
- TTNPB
Synthetic stilbene analog of retinoic acid that acts as a potent retinoic acid receptor (RAR) agonist.| Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-203303 | 71441-28-6 | C24H28O2 | 10 mg |
- WAY 208466 dihydrochloride
| Catalog # | CAS Number | Molecular Formula | Unit |
|---|
| sc-361404 | 633304-27-5 | C17H18FN3O2S ·2HCl | 10 mg |
- YC-1
A compound that can activate platelet soluble guanylate cylcase (sGC) indepedent of nitric oxide activation. | Catalog # | CAS Number | Molecular Formula | Unit |
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| sc-202856 | 170632-47-0 | C19H16N2O2 | 1 mg |
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